# Validamycin

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Not to be confused with [Valinomycin](/source/Valinomycin).

**Validamycin** is an [antibiotic](/source/Antibiotic) and [fungicide](/source/Fungicide) produced by *[Streptomyces hygroscopicus](/source/Streptomyces_hygroscopicus)*. An inhibitor of [trehalase](/source/Trehalase),[1] validamycin is used for the control of [sheath blight of rice](/source/Sheath_blight_of_rice) and damping-off of cucumbers.

## See also

- [Ralstonia solanacearum](/source/Ralstonia_solanacearum)

## References

1. Li, H.; Su, H.; Kim, S. B.; Chang, Y. K.; Hong, S. K.; Seo, Y. G.; Kim, C. J. (2011). "Enhanced production of trehalose in Escherichia coli by homologous expression of otsBA in the presence of the trehalase inhibitor, validamycin A, at high osmolarity". *[Journal of Bioscience and Bioengineering](/source/Journal_of_Bioscience_and_Bioengineering)*. **113** (2): 224–32. [doi:10.1016/j.jbiosc.2011.09.018](https://doi.org/10.1016/j.jbiosc.2011.09.018). [PMID 22036231](https://pubmed.ncbi.nlm.nih.gov/22036231)

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