# Vacuolar interface dermatitis
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[[File:Vacuolar interface dermatitis, annotated.jpg|thumb|Vacuolar interface dermatitis, with lymphocytes in the dermis and epidermis (black arrow indicates one), and [vacuolization](/source/vacuolization) (white arrow) at the [dermoepidermal junction](/source/dermoepidermal_junction).]]
[[Image:Vacuolar interface dermatitis - high mag.jpg|thumb|right|[Micrograph](/source/Micrograph) of a vacuolar interface dermatitis with dermal mucin, as may be seen in [lupus](/source/systemic_lupus_erythematosus). [H&E stain](/source/H%26E_stain).]]
'''Vacuolar interface dermatitis''' ('''VAC''', also known as '''liquefaction degeneration''', '''vacuolar alteration''' or '''hydropic degeneration''') is a [dermatitis](/source/dermatitis) with [vacuolization](/source/vacuolization) at the [dermoepidermal junction](/source/dermoepidermal_junction), with lymphocytic inflammation at the epidermis and dermis.[{{cite book |author=Bolognia, Jean L.|title=Dermatology |publisher=Mosby |location=St. Louis |year=2007 |pages=11 |isbn=1-4160-2999-0 |display-authors=etal}}]
==Causes==
{{Table of causes of vacuolar interface dermatitis}}
An interface dermatitis with [vacuolar](/source/Vacuole) alteration, not otherwise specified, may be caused by viral [exanthems](/source/Exanthem), [phototoxic dermatitis](/source/Photodermatitis), acute [radiation dermatitis](/source/Radiation_burn), [erythema dyschromicum perstans](/source/erythema_dyschromicum_perstans), [lupus erythematosus](/source/lupus_erythematosus) and [dermatomyositis](/source/dermatomyositis).