# VIS1

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Gene in the species Homo sapiens

VIS1 Identifiers Aliases VIS1, HIS-1, HIS1, viral integration site 1 External IDs OMIM: 164755; GeneCards: VIS1; OMA:VIS1 - orthologs Orthologs Species Human Mouse Entrez 7435 n/a Ensembl ENSG00000276706 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search [1] n/a Wikidata View/Edit Human

**VIS1** (viral integration site 1), also known as HIS-1, is a [long non-coding RNA](/source/Long_non-coding_RNA). It was originally identified in mice in a screen for genes involved in the development of [myeloid leukemia](/source/Myeloid_leukemia). In [murine](/source/Murine) myeloid leukemias, this gene is a common site of viral insertion by the murine [ecotropic](/source/Ecotropic) [retrovirus](/source/Retrovirus) CasBrM[2][3] It is conserved amongst [vertebrates](/source/Vertebrates), including human, mice, cats, pigs, cattle and dogs.[4] Expression of VIS1 is restricted to [epithelial](/source/Epithelial) cells, [leukemias](/source/Leukemias) and [carcinomas](/source/Carcinomas).[5]

## See also

- [Long noncoding RNA](/source/Long_noncoding_RNA)

## References

1. **[^](#cite_ref-1)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7435). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid1682866_2-0)** Askew DS, Bartholomew C, Buchberg AM, et al. (November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". *Oncogene*. **6** (11): 2041–2047. [PMID](/source/PMID_(identifier)) [1682866](https://pubmed.ncbi.nlm.nih.gov/1682866).

1. **[^](#cite_ref-pmid8114708_3-0)** Askew DS, Li J, Ihle JN (March 1994). ["Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC358532). *Mol. Cell. Biol*. **14** (3): 1743–1751. [doi](/source/Doi_(identifier)):[10.1128/MCB.14.3.1743](https://doi.org/10.1128%2FMCB.14.3.1743). [PMC](/source/PMC_(identifier)) [358532](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC358532). [PMID](/source/PMID_(identifier)) [8114708](https://pubmed.ncbi.nlm.nih.gov/8114708).

1. **[^](#cite_ref-pmid9031624_4-0)** Li J, Rhodes JC, Askew DS (January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". *Gene*. **184** (2): 169–176. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(96)00591-4](https://doi.org/10.1016%2FS0378-1119%2896%2900591-4). [PMID](/source/PMID_(identifier)) [9031624](https://pubmed.ncbi.nlm.nih.gov/9031624).

1. **[^](#cite_ref-pmid9094986_5-0)** Li J, Witte DP, Van Dyke T, Askew DS (April 1997). ["Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858164). *Am. J. Pathol*. **150** (4): 1297–1305. [PMC](/source/PMC_(identifier)) [1858164](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858164). [PMID](/source/PMID_(identifier)) [9094986](https://pubmed.ncbi.nlm.nih.gov/9094986).

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