# UNC5A

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Protein-coding gene in the species Homo sapiens

UNC5A Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V2A Identifiers Aliases UNC5A, UNC5H1, unc-5 netrin receptor A External IDs OMIM: 607869; MGI: 894682; HomoloGene: 41474; GeneCards: UNC5A; OMA:UNC5A - orthologs Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,810,519 bp[1] End 176,880,898 bp[1] Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,097,224 bp[2] End 55,153,831 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 primary visual cortex right hemisphere of cerebellum right frontal lobe prefrontal cortex superior frontal gyrus Brodmann area 9 postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex secondary oocyte superior frontal gyrus lumbar subsegment of spinal cord hippocampus proper humerus transitional epithelium of urinary bladder primary oocyte neural layer of retina More reference expression data BioGPS n/a Gene ontology Molecular function netrin receptor activity Cellular component intrinsic component of plasma membrane integral component of membrane neuronal cell body membrane membrane raft plasma membrane cell projection neuron projection membrane membrane Biological process multicellular organism development neuron projection development signal transduction anterior/posterior axon guidance axon guidance apoptotic process netrin-activated signaling pathway Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 90249 107448 Ensembl ENSG00000113763 ENSMUSG00000025876 UniProt Q6ZN44 Q8K1S4 RefSeq (mRNA) NM_133369 NM_153131 NM_001311128 RefSeq (protein) NP_588610 NP_001298057 NP_694771 Location (UCSC) Chr 5: 176.81 – 176.88 Mb Chr 13: 55.1 – 55.15 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Netrin receptor UNC5A** is a [protein](/source/Protein) that in humans is encoded by the *UNC5A* [gene](/source/Gene).[5]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][5]

## Interactions

UNC5A has been shown to [interact](/source/Protein-protein_interaction) with [MAGED1](/source/MAGED1).[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000113763](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000113763) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000025876](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000025876) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=90249). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=107448). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-entrez_5-0) [***b***](#cite_ref-entrez_5-1) ["Entrez Gene: UNC5A unc-5 homolog A (C. elegans)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=90249).

1. **[^](#cite_ref-pmid12598531_6-0)** Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). ["UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE"](https://doi.org/10.1074%2Fjbc.M300415200). *The Journal of Biological Chemistry*. **278** (19): 17483–90. [doi](/source/Doi_(identifier)):[10.1074/jbc.M300415200](https://doi.org/10.1074%2Fjbc.M300415200). [PMID](/source/PMID_(identifier)) [12598531](https://pubmed.ncbi.nlm.nih.gov/12598531).

## Further reading

- Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". *Nature Reviews. Cancer*. **4** (12): 978–87. [doi](/source/Doi_(identifier)):[10.1038/nrc1504](https://doi.org/10.1038%2Fnrc1504). [PMID](/source/PMID_(identifier)) [15573119](https://pubmed.ncbi.nlm.nih.gov/15573119). [S2CID](/source/S2CID_(identifier)) [867903](https://api.semanticscholar.org/CorpusID:867903).

- Bonaldo MF, Lennon G, Soares MB (September 1996). ["Normalization and subtraction: two approaches to facilitate gene discovery"](https://doi.org/10.1101%2Fgr.6.9.791). *Genome Research*. **6** (9): 791–806. [doi](/source/Doi_(identifier)):[10.1101/gr.6.9.791](https://doi.org/10.1101%2Fgr.6.9.791). [PMID](/source/PMID_(identifier)) [8889548](https://pubmed.ncbi.nlm.nih.gov/8889548).

- Nagase T, Kikuno R, Ohara O (December 2001). ["Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins"](https://doi.org/10.1093%2Fdnares%2F8.6.319). *DNA Research*. **8** (6): 319–27. [doi](/source/Doi_(identifier)):[10.1093/dnares/8.6.319](https://doi.org/10.1093%2Fdnares%2F8.6.319). [PMID](/source/PMID_(identifier)) [11853319](https://pubmed.ncbi.nlm.nih.gov/11853319).

- Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). ["UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE"](https://doi.org/10.1074%2Fjbc.M300415200). *The Journal of Biological Chemistry*. **278** (19): 17483–90. [doi](/source/Doi_(identifier)):[10.1074/jbc.M300415200](https://doi.org/10.1074%2Fjbc.M300415200). [PMID](/source/PMID_(identifier)) [12598531](https://pubmed.ncbi.nlm.nih.gov/12598531).

- Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". *Nature Cell Biology*. **5** (3): 216–23. [doi](/source/Doi_(identifier)):[10.1038/ncb943](https://doi.org/10.1038%2Fncb943). [PMID](/source/PMID_(identifier)) [12598906](https://pubmed.ncbi.nlm.nih.gov/12598906). [S2CID](/source/S2CID_(identifier)) [7017409](https://api.semanticscholar.org/CorpusID:7017409).

- Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). ["The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153067). *Proceedings of the National Academy of Sciences of the United States of America*. **100** (7): 4173–8. [Bibcode](/source/Bibcode_(identifier)):[2003PNAS..100.4173T](https://ui.adsabs.harvard.edu/abs/2003PNAS..100.4173T). [doi](/source/Doi_(identifier)):[10.1073/pnas.0738063100](https://doi.org/10.1073%2Fpnas.0738063100). [PMC](/source/PMC_(identifier)) [153067](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153067). [PMID](/source/PMID_(identifier)) [12655055](https://pubmed.ncbi.nlm.nih.gov/12655055).

- Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). ["Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin"](https://doi.org/10.1074%2Fjbc.M302943200). *The Journal of Biological Chemistry*. **278** (35): 32561–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.M302943200](https://doi.org/10.1074%2Fjbc.M302943200). [PMID](/source/PMID_(identifier)) [12810718](https://pubmed.ncbi.nlm.nih.gov/12810718).

- Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). ["The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556396). *The EMBO Journal*. **24** (6): 1192–201. [doi](/source/Doi_(identifier)):[10.1038/sj.emboj.7600584](https://doi.org/10.1038%2Fsj.emboj.7600584). [PMC](/source/PMC_(identifier)) [556396](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556396). [PMID](/source/PMID_(identifier)) [15729359](https://pubmed.ncbi.nlm.nih.gov/15729359).

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