# UCN2

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**Urocortin-2** is a [protein](/source/Protein) that in humans is encoded by the *UCN2* [gene](/source/Gene).[1][2]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the [corticotropin-releasing factor](/source/Corticotropin-releasing_factor) (CRF) gene and the encoded product is an endogenous [ligand](/source/Ligand) for CRF type 2 receptors. In the [brain](/source/Brain) it may be responsible for the effects of [stress](/source/Stress_(biology)) on [appetite](/source/Appetite). In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[2]

## References

1. Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". *Nat Med*. **7** (5): 605–11. [doi:10.1038/87936](https://doi.org/10.1038/87936). [PMID 11329063](https://pubmed.ncbi.nlm.nih.gov/11329063). [S2CID 22916906](https://api.semanticscholar.org/CorpusID:22916906)

1. ["Entrez Gene: UCN2 urocortin 2"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=90226)

## Further reading

- Hauger RL, Grigoriadis DE, Dallman MF, etal (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands.". *Pharmacol. Rev.*. **55** (1): 21–6. [doi:10.1124/pr.55.1.3](https://doi.org/10.1124/pr.55.1.3). [PMID 12615952](https://pubmed.ncbi.nlm.nih.gov/12615952). [S2CID 1572317](https://api.semanticscholar.org/CorpusID:1572317)
- Florio P, Torres PB, Torricelli M, etal (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides.". *Fertil. Steril.*. **86** (6): 1766–70. [doi:10.1016/j.fertnstert.2006.05.041](https://doi.org/10.1016/j.fertnstert.2006.05.041). [PMID 17074339](https://pubmed.ncbi.nlm.nih.gov/17074339)
- Imperatore A, Florio P, Torres PB, etal (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes.". *Am. J. Obstet. Gynecol.*. **195** (1): 288–95. [doi:10.1016/j.ajog.2005.12.048](https://doi.org/10.1016/j.ajog.2005.12.048). [PMID 16626608](https://pubmed.ncbi.nlm.nih.gov/16626608)
- Isfort RJ, Wang F, Tscheiner M, etal (2006). "Modifications of the human urocortin 2 peptide that improve pharmacological properties.". *Peptides*. **27** (7): 1806–13. [doi:10.1016/j.peptides.2006.01.003](https://doi.org/10.1016/j.peptides.2006.01.003). [PMID 16476507](https://pubmed.ncbi.nlm.nih.gov/16476507). [S2CID 41513209](https://api.semanticscholar.org/CorpusID:41513209)
- Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats.". *Am. J. Physiol. Gastrointest. Liver Physiol.*. **290** (3): G511–8. [CiteSeerX 10.1.1.328.810](https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.810). [doi:10.1152/ajpgi.00289.2005](https://doi.org/10.1152/ajpgi.00289.2005). [PMID 16223946](https://pubmed.ncbi.nlm.nih.gov/16223946). [S2CID 10157248](https://api.semanticscholar.org/CorpusID:10157248)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates.". *Peptides*. **25** (10): 1681–8. [doi:10.1016/j.peptides.2004.05.022](https://doi.org/10.1016/j.peptides.2004.05.022). [PMID 15476935](https://pubmed.ncbi.nlm.nih.gov/15476935). [S2CID 25716793](https://api.semanticscholar.org/CorpusID:25716793)
- Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.". *Endocrinology*. **145** (2): 890–900. [doi:10.1210/en.2003-1210](https://doi.org/10.1210/en.2003-1210). [PMID 14592950](https://pubmed.ncbi.nlm.nih.gov/14592950)
- Chanalaris A, Lawrence KM, Stephanou A, etal (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.". *J. Mol. Cell. Cardiol.*. **35** (10): 1295–305. [doi:10.1016/S0022-2828(03)00244-X](https://doi.org/10.1016/S0022-2828(03)00244-X). [PMID 14519439](https://pubmed.ncbi.nlm.nih.gov/14519439)
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Lewis K, Li C, Perrin MH, etal (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". *Proc. Natl. Acad. Sci. U.S.A.*. **98** (13): 7570–5. [Bibcode:2001PNAS...98.7570L](https://ui.adsabs.harvard.edu/abs/2001PNAS...98.7570L). [doi:10.1073/pnas.121165198](https://doi.org/10.1073/pnas.121165198). [PMC 34709](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34709). [PMID 11416224](https://pubmed.ncbi.nlm.nih.gov/11416224)
- Reyes TM, Lewis K, Perrin MH, etal (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors.". *Proc. Natl. Acad. Sci. U.S.A.*. **98** (5): 2843–8. [Bibcode:2001PNAS...98.2843R](https://ui.adsabs.harvard.edu/abs/2001PNAS...98.2843R). [doi:10.1073/pnas.051626398](https://doi.org/10.1073/pnas.051626398). [PMC 30227](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30227). [PMID 11226328](https://pubmed.ncbi.nlm.nih.gov/11226328)

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Adapted from the Wikipedia article [UCN2](https://en.wikipedia.org/wiki/UCN2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/UCN2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.