# Trichodiene synthase

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The [enzyme](/source/Enzyme) **trichodiene synthase** (EC 4.2.3.6) [catalyzes](/source/Catalysis) the [chemical reaction](/source/Chemical_reaction)

- (2*E*,6*E*)-farnesyl diphosphate \rightleftharpoons trichodiene + diphosphate

This enzyme belongs to the family of [lyases](/source/Lyase), specifically those carbon-oxygen lyases acting on phosphates. The [systematic name](/source/List_of_enzymes) of this enzyme class is **(2*E*,6*E*)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)**. Other names in common use include **trichodiene synthetase**, **sesquiterpene cyclase**, and ***trans,trans*-farnesyl-diphosphate sesquiterpenoid-lyase**. This enzyme participates in [terpenoid biosynthesis](/source/Terpenoid_biosynthesis).

## Structural studies

As of late 2007, 9 [structures](/source/Tertiary_structure) have been solved for this class of enzymes, with [PDB](/source/Protein_Data_Bank) accession codes , , , , , , , , and .

## References

- Hohn TM, Vanmiddlesworth F (1986). ["Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides"](https://naldc-legacy.nal.usda.gov/naldc/download.xhtml?id=23897&content=PDF). *Arch. Biochem. Biophys.*. **251** (2): 756–61. [doi:10.1016/0003-9861(86)90386-3](https://doi.org/10.1016/0003-9861(86)90386-3). [PMID 3800398](https://pubmed.ncbi.nlm.nih.gov/3800398)[dead link]

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Adapted from the Wikipedia article [Trichodiene synthase](https://en.wikipedia.org/wiki/Trichodiene_synthase) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Trichodiene_synthase?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.