# Trichodermin

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Trichodermin
> Markdown URL: https://mediated.wiki/source/Trichodermin.md
> Source: https://en.wikipedia.org/wiki/Trichodermin
> Source revision: 1307749218
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{chembox
| verifiedrevid = 424684079
| ImageFile=Trichodermin.png
| ImageSize=200px
| IUPACName=12,13-Epoxytrichothec-9-en-4β-yl acetate
| SystematicName=(2''R'',2′''S'',4''R'',5''S'',5a''R'',9a''R'')-5,5a,8-Trimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[<nowiki/>[2,5]methano[1]benzoxepine-10,2′-oxiran]-4-yl acetate
| OtherNames=
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=4682-50-2
| Beilstein = 6868411
| ChEBI = 9688
| ChEMBL = 4463552
| ChemSpiderID = 19582
| KEGG = C09741
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = WF22557W91
| PubChem=20806
| StdInChI=1S/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17+/m1/s1
| StdInChIKey = HNEGCRMUYSKRRR-IKIFYQGPSA-N
| SMILES=CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H](C[C@H]([C@@]34CO4)O2)OC(=O)C)C)C
  }}
|Section2={{Chembox Properties
| Formula=C<sub>17</sub>H<sub>24</sub>O<sub>4</sub>
| MolarMass=292.37 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
  }}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
  }}
}}

'''Trichodermin''' is a [trichothecene](/source/trichothecene).<ref>{{cite journal |last1=Wei |first1=Cha-mer |last2=Hansen |first2=Bent S. |last3=Vaughan |first3=Maurice H. |last4=McLaughlin |first4=Calvin S. |title=Mechanism of Action of the Mycotoxin Trichodermin, a 12,13-Epoxytrichothecene |journal=Proceedings of the National Academy of Sciences |date=March 1974 |volume=71 |issue=3 |pages=713–717 |doi=10.1073/pnas.71.3.713 |pmid=4522785 |bibcode=1974PNAS...71..713W |doi-access=free |pmc=388083 }}</ref> It inhibits protein formation in Euchariotes.<ref>{{cite journal |last1=Carrasco |first1=L. |last2=Barbacid |first2=M. |last3=Vazquez |first3=D. |title=The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomes |journal=Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis |date=June 1973 |volume=312 |issue=2 |pages=368–376 |doi=10.1016/0005-2787(73)90381-X |pmid=4579233 }}</ref>

==References==
{{Reflist}}

Category:Trichothecenes
Category:Epoxides
Category:Acetate esters

{{Ether-stub}}

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Adapted from the Wikipedia article [Trichodermin](https://en.wikipedia.org/wiki/Trichodermin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Trichodermin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.