# Transphosphorylation

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Transphosphorylation
> Markdown URL: https://mediated.wiki/source/Transphosphorylation.md
> Source: https://en.wikipedia.org/wiki/Transphosphorylation
> Source revision: 1306861233
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Multiple issues|{{Duplication|date=October 2021|dupe=Phosphorylation}}
{{context|date=November 2016}}}}
thumb|right|450px
'''Transphosphorylation''' is a [chemical reaction](/source/chemical_reaction) in which a [phosphate](/source/phosphate) group or a [phosphono group](/source/Phosphonic_acid) is transferred between a [substrate](/source/substrate_(chemistry)) and a [receptor](/source/receptor_(biochemistry)).<ref>{{Cite journal |last1=Ardecky |first1=Robert J. |last2=Bobkova |first2=Ekaterina V. |last3=Kiffer-Moreira |first3=Tina |last4=Brown |first4=Brock |last5=Ganji |first5=Santhi |last6=Zou |first6=Jiwen |last7=Pass |first7=Ian |last8=Narisawa |first8=Sonoko |last9=Iano |first9=Flávia Godoy |last10=Rosenstein |first10=Craig |last11=Cheltsov |first11=Anton |last12=Rascon |first12=Justin |last13=Hedrick |first13=Michael |last14=Gasior |first14=Carlton |last15=Forster |first15=Anita |date=2014-02-01 |title=Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes |journal=Bioorganic & Medicinal Chemistry Letters |volume=24 |issue=3 |pages=1000–1004 |doi=10.1016/j.bmcl.2013.12.043 |issn=1464-3405 |pmc=3943210 |pmid=24412070}}</ref> There are various phosphate [ester](/source/ester)s in living body including [nucleic acid](/source/nucleic_acid), and phosphorylation reaction related to their synthesis and interconversion is the basis of biochemical reaction.<ref>{{Cite journal |last1=Wang |first1=Qian |last2=Kang |first2=Yoon-Suk |last3=Alowaifeer |first3=Abdullah |last4=Shi |first4=Kaixiang |last5=Fan |first5=Xia |last6=Wang |first6=Lu |last7=Jetter |first7=Jonathan |last8=Bothner |first8=Brian |last9=Wang |first9=Gejiao |last10=McDermott |first10=Timothy R. |date=2018-05-25 |title=Phosphate starvation response controls genes required to synthesize the phosphate analog arsenate |journal=Environmental Microbiology |volume=20 |issue=5 |pages=1782–1793 |doi=10.1111/1462-2920.14108 |issn=1462-2920 |pmid=29575522|bibcode=2018EnvMi..20.1782W |s2cid=4700039 }}</ref><ref>{{Cite journal |last1=Tasnádi |first1=Gábor |last2=Zechner |first2=Michaela |last3=Hall |first3=Mélanie |last4=Baldenius |first4=Kai |last5=Ditrich |first5=Klaus |last6=Faber |first6=Kurt |date=2017-10-06 |title=Investigation of acid phosphatase variants for the synthesis of phosphate monoesters |journal=Biotechnology and Bioengineering |volume=114 |issue=10 |pages=2187–2195 |doi=10.1002/bit.26352 |issn=1097-0290 |pmid=28600898|bibcode=2017BiotB.114.2187T |s2cid=25563592 }}</ref> In most cases, [ATP](/source/Adenosine_triphosphate) is the substrate of the phosphate group as a substrate and the [enzyme](/source/enzyme) that catalyzes these reactions is referred to as [kinase](/source/kinase).<ref>{{Cite journal |last1=Wan |first1=Paul T. C. |last2=Garnett |first2=Mathew J. |last3=Roe |first3=S. Mark |last4=Lee |first4=Sharlene |last5=Niculescu-Duvaz |first5=Dan |last6=Good |first6=Valerie M. |last7=Jones |first7=C. Michael |last8=Marshall |first8=Christopher J. |last9=Springer |first9=Caroline J. |last10=Barford |first10=David |last11=Marais |first11=Richard |last12=Cancer Genome Project |date=2004-03-19 |title=Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF |journal=Cell |volume=116 |issue=6 |pages=855–867 |doi=10.1016/s0092-8674(04)00215-6 |issn=0092-8674 |pmid=15035987|doi-access=free }}</ref>

== References ==
{{Reflist}}

Category:Chemical reactions

---
Adapted from the Wikipedia article [Transphosphorylation](https://en.wikipedia.org/wiki/Transphosphorylation) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Transphosphorylation?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.