# Transcriptome instability

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Transcriptome instability is a [genome](/source/Genome)-wide, [pre-mRNA splicing](/source/RNA_splicing)-related characteristic of certain [cancers](/source/Cancer). In general, pre-mRNA splicing is dysregulated in a high proportion of cancerous [cells](/source/Cell_(biology)).[1][2][3] For certain types of cancer, like in [colorectal](/source/Colorectal_cancer) and [prostate](/source/Prostate_cancer), the number of splicing errors per cancer has been shown to vary greatly between individual cancers, a phenomenon referred to as **transcriptome instability**.[4][5] Transcriptome instability correlates significantly with reduced expression level of splicing factor genes. Mutation of *[DNMT3A](/source/DNMT3A)* contributes to development of [hematologic malignancies](/source/Hematologic_malignancies), and *[DNMT3A](/source/DNMT3A)*-mutated cell lines exhibit **transcriptome instability** as compared to their isogenic wildtype counterparts.[6]

## References

1. **[^](#cite_ref-Skotheim_and_Nees_2007_1-0)** Skotheim, R I; Nees, M (2007). "Alternative splicing in cancer: noise, functional, or systematic?". *The International Journal of Biochemistry & Cell Biology*. **39** (7–8): 1432–49. [doi](/source/Doi_(identifier)):[10.1016/j.biocel.2007.02.016](https://doi.org/10.1016%2Fj.biocel.2007.02.016). [PMID](/source/PMID_(identifier)) [17416541](https://pubmed.ncbi.nlm.nih.gov/17416541).

1. **[^](#cite_ref-He2009_2-0)** Bauer, Joseph Alan; He, Chunjiang; Zhou, Fang; Zuo, Zhixiang; Cheng, Hanhua; Zhou, Rongjia (2009). Bauer, Joseph Alan (ed.). ["A Global View of Cancer-Specific Transcript Variants by Subtractive Transcriptome-Wide Analysis"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648985). *PLOS ONE*. **4** (3) e4732. [Bibcode](/source/Bibcode_(identifier)):[2009PLoSO...4.4732H](https://ui.adsabs.harvard.edu/abs/2009PLoSO...4.4732H). [doi](/source/Doi_(identifier)):[10.1371/journal.pone.0004732](https://doi.org/10.1371%2Fjournal.pone.0004732). [PMC](/source/PMC_(identifier)) [2648985](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648985). [PMID](/source/PMID_(identifier)) [19266097](https://pubmed.ncbi.nlm.nih.gov/19266097).

1. **[^](#cite_ref-Sveen_2015_3-0)** Sveen, A; Kilpinen, S; Ruusulehto, A; Lothe, RA; Skotheim, RI (2015). ["Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes"](https://doi.org/10.1038%2Fonc.2015.318). *Oncogene*. **35** (19): 2413–2427. [doi](/source/Doi_(identifier)):[10.1038/onc.2015.318](https://doi.org/10.1038%2Fonc.2015.318). [PMID](/source/PMID_(identifier)) [26300000](https://pubmed.ncbi.nlm.nih.gov/26300000).

1. **[^](#cite_ref-Sveen_2011_4-0)** Sveen, A; Ågesen, TH; Nesbakken, A; Rognum, TO; Lothe, RA; Skotheim, RI (2011). ["Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival"](http://www.genomemedicine.com/content/3/5/32). *Genome Medicine*. **15** (1): 672. [doi](/source/Doi_(identifier)):[10.1186/1471-2164-15-672](https://doi.org/10.1186%2F1471-2164-15-672). [PMC](/source/PMC_(identifier)) [3219073](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219073). [PMID](/source/PMID_(identifier)) [25109687](https://pubmed.ncbi.nlm.nih.gov/25109687).

1. **[^](#cite_ref-Sveen_2014_5-0)** Sveen, A; Johannessen, B; Teixeira, MR; Lothe, RA; Skotheim, RI (2014). ["Transcriptome instability as a molecular pan-cancer characteristic of carcinomas"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137096). *BMC Genomics*. **3** (5): 32. [doi](/source/Doi_(identifier)):[10.1186/gm248](https://doi.org/10.1186%2Fgm248). [PMC](/source/PMC_(identifier)) [4137096](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137096). [PMID](/source/PMID_(identifier)) [21619627](https://pubmed.ncbi.nlm.nih.gov/21619627).

1. **[^](#cite_ref-Banaszak_2018_6-0)** Banaszak, LG; Giudice, V; Zhao, X; Wu, Z; Gao, S; Hosokawa, K; Keyvanfar, K; Townsley, DM; Gutierrez-Rodrigues, F; Ibanez, MdPF; Kajigaya, S; Young, NS (2018). ["Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728079). *Blood Cells, Molecules and Diseases*. **69**: 10–22. [doi](/source/Doi_(identifier)):[10.1016/j.bcmd.2017.12.002](https://doi.org/10.1016%2Fj.bcmd.2017.12.002). [PMC](/source/PMC_(identifier)) [6728079](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728079). [PMID](/source/PMID_(identifier)) [29324392](https://pubmed.ncbi.nlm.nih.gov/29324392).

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Adapted from the Wikipedia article [Transcriptome instability](https://en.wikipedia.org/wiki/Transcriptome_instability) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Transcriptome_instability?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.