# Transcript of unknown function

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{{short description|Known RNA transcripts of DNA whose function is unclear}}
'''Transcripts of unknown function (TUFs)''' is the name that has been suggested for known [RNA transcripts](/source/RNA) of [DNA](/source/DNA) whose function is unclear.  Most are probably [ncRNAs](/source/Non-coding_RNA), such as [RNAi](/source/RNAi) or [snoRNA](/source/snoRNA)s, but could also represent a whole new class of ncRNA.<ref name="Gingeras">{{cite journal | last = Gingeras | first = Thomas R. | year = 2007 | title = Origin of phenotypes: Genes and transcripts | journal = Genome Research | volume = 17| issue = 6 | pages = 682–690 | doi = 10.1101/gr.6525007 | pmid = 17567989 | doi-access = free }}</ref> Their [DNA sequence](/source/DNA_sequence)s reside in the [intergenic](/source/Intergenic_region) or [intron](/source/intron)ic regions of the [genome](/source/genome), which is often called [junk DNA](/source/junk_DNA).

== Categories ==
Broadly speaking, TUFs can be classified into three categories:<ref name="Gingeras" />
# TUFs that are complementary to [sense transcripts](/source/Sense_(molecular_biology)) of protein-coding [gene](/source/gene)s
# TUFs that are novel [isoform](/source/Protein_isoform) transcripts of protein-coding genes; this can include expressed [pseudogene](/source/pseudogene)s
# TUFs that reside on the same strand as protein-coding genes in the intronic region or entirely in the intergenic region

== References ==
{{reflist}}

{{DEFAULTSORT:Transcript Of Unknown Function}}
Category:Molecular genetics
Category:RNA
Category:Non-coding RNA

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