# Taspine

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**Taspine** is an [alkaloid](/source/Alkaloid) which acts as a potent [acetylcholinesterase inhibitor](/source/Acetylcholinesterase_inhibitor) and [cicatrizant](/source/Cicatrizant). It is found in various plants including *[Magnolia x soulangeana](/source/Magnolia_x_soulangeana)*[1] and *[Croton lechleri](/source/Croton_lechleri)*.[2]

The first total synthesis was reported by T. Ross Kelly and Roger L. Xie in 1998.[3]

## References

1. Rollinger, JM; Schuster, D; Baier, E; Ellmerer, EP; Langer, T; Stuppner, H (2006). "Taspine: Bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from *Magnolia* x *soulangiana*". *Journal of Natural Products*. **69** (9): 1341–1346. [doi:10.1021/np060268p](https://doi.org/10.1021/np060268p). [PMC 3526713](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526713). [PMID 16989531](https://pubmed.ncbi.nlm.nih.gov/16989531)

1. Vaisberg, A.; Milla, M.; Planas, M.; Cordova, J.; De Agusti, E.; Ferreyra, R.; Mustiga, M.; Carlin, L.; Hammond, G. (2007). "Taspine is the Cicatrizant Principle in Sangre de Grado Extracted from *Croton lechleri*". *Planta Medica*. **55** (2): 140–143. [doi:10.1055/s-2006-961907](https://doi.org/10.1055/s-2006-961907). [PMID 2748730](https://pubmed.ncbi.nlm.nih.gov/2748730). [S2CID 260251205](https://api.semanticscholar.org/CorpusID:260251205)

1. Kelly, T. Ross & Xie, Roger L. (October 1998). "Total Synthesis of Taspine". *The Journal of Organic Chemistry*. **63** (22): 8045–8048. [doi:10.1021/jo981099j](https://doi.org/10.1021/jo981099j)

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