# Target protein

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> Source: https://en.wikipedia.org/wiki/Target_protein
> Source revision: 1312372607
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

'''Target proteins''' are functional [biomolecule](/source/biomolecule)s that are addressed and controlled by [biologically active compounds](/source/drug). They are used in the processes of transduction, transformation and conjugation. The identification of target proteins, the investigation of [signal transduction](/source/signal_transduction) processes and the understanding of their interaction with [ligands](/source/ligand_(biochemistry)) are key elements of modern biomedical research. Since the interaction with target proteins is the molecular origin of most [drug](/source/drug)s, their particular importance for [molecular biology](/source/molecular_biology), molecular pharmacy and [pharmaceutical sciences](/source/pharmacy) is obvious. Target proteins control the action and the [kinetic behavior](/source/Pharmacokinetics) of drugs within the organism. The elucidation of structure, [conformational](/source/Protein_conformation) signaling and [catalytic properties](/source/biocatalysis) of particular target proteins facilitates a rational [design of drugs](/source/drug_design) and [biotechnological processes](/source/Biotechnology). Known as [biologicals](/source/Recombinant_protein), target proteins can also be drugs by themselves when their modification and formulation is emphasized within the pharmaceutical sciences. Finally, target protein - [inducer](/source/Enzyme_induction_and_inhibition) interactions can be exploited for biomolecular [transcription](/source/transcription_(genetics)) regulating systems in order to control for example [gene therapeutic approaches](/source/gene_therapy).

== See also ==
* [Biological target](/source/Biological_target)

== References ==
* {{cite journal |vauthors=Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J |title=The reactive metabolite target protein database (TPDB) – a web-accessible resource |journal=BMC Bioinformatics |volume=8|article-number=95 |year=2007 |pmid=17367530 |pmc=1832215 |doi=10.1186/1471-2105-8-95 |doi-access=free }}

== External links ==
* [http://tpdb.medchem.ku.edu:8080/protein_database/ Target Protein Database] of the University of Kansas
* [https://www.proteinpromo.com/myprotein/ Myprotein]

Category:Drug discovery

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