# TUB (gene)

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Protein-coding gene in the species Homo sapiens

TUB Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S31 Identifiers Aliases TUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor External IDs OMIM: 601197; MGI: 2651573; HomoloGene: 31147; GeneCards: TUB; OMA:TUB - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,019,244 bp[1] End 8,106,243 bp[1] Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 108,549,545 bp[2] End 108,633,667 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars reticulata pars compacta middle temporal gyrus postcentral gyrus entorhinal cortex superior frontal gyrus superior vestibular nucleus pons ventral tegmental area pituitary gland Top expressed in neural layer of retina dorsomedial hypothalamic nucleus arcuate nucleus subiculum ventromedial nucleus anterior amygdaloid area paraventricular nucleus of hypothalamus dentate gyrus of hippocampal formation granule cell habenula lateral hypothalamus More reference expression data BioGPS More reference expression data Gene ontology Molecular function phosphatidylinositol binding protein-containing complex binding G protein-coupled receptor binding intraciliary transport particle A binding Cellular component cytoplasm extracellular region cytosol plasma membrane cilium membrane nucleus Biological process phagocytosis, recognition receptor localization to non-motile cilium response to hormone positive regulation of phagocytosis photoreceptor cell maintenance hearing retina development in camera-type eye protein localization to photoreceptor outer segment response to stimulus phagocytosis protein localization to cilium regulation of G protein-coupled receptor signaling pathway intraciliary transport Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 7275 22141 Ensembl ENSG00000166402 ENSMUSG00000031028 UniProt P50607 P50586 RefSeq (mRNA) NM_003320 NM_177972 NM_021885 RefSeq (protein) NP_003311 NP_813977 NP_068685 Location (UCSC) Chr 11: 8.02 – 8.11 Mb Chr 7: 108.55 – 108.63 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Tubby protein homolog** is a [protein](/source/Protein) that in humans is encoded by the *TUB* [gene](/source/Gene).[5][6]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

## Interactions

TUB (gene) has been shown to [interact](/source/Protein-protein_interaction) with [PLCG1](/source/PLCG1).[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000166402](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000166402) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000031028](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000031028) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7275). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=22141). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8612280_5-0)** Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). ["Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family"](https://doi.org/10.1016%2FS0092-8674%2800%2981104-6). *Cell*. **85** (2): 281–90. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(00)81104-6](https://doi.org/10.1016%2FS0092-8674%2800%2981104-6). [PMID](/source/PMID_(identifier)) [8612280](https://pubmed.ncbi.nlm.nih.gov/8612280). [S2CID](/source/S2CID_(identifier)) [15670925](https://api.semanticscholar.org/CorpusID:15670925).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: TUB tubby homolog (mouse)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7275).

1. **[^](#cite_ref-pmid10455176_7-0)** Kapeller, R; Moriarty A; Strauss A; Stubdal H; Theriault K; Siebert E; Chickering T; Morgenstern J P; Tartaglia L A; Lillie J (Aug 1999). ["Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin"](https://doi.org/10.1074%2Fjbc.274.35.24980). *J. Biol. Chem*. **274** (35). UNITED STATES: 24980–6. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.35.24980](https://doi.org/10.1074%2Fjbc.274.35.24980). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [10455176](https://pubmed.ncbi.nlm.nih.gov/10455176).

## Further reading

- Ikeda A, Nishina PM, Naggert JK (2002). ["The tubby-like proteins, a family with roles in neuronal development and function"](https://doi.org/10.1242%2Fjcs.115.1.9). *J. Cell Sci*. **115** (Pt 1): 9–14. [doi](/source/Doi_(identifier)):[10.1242/jcs.115.1.9](https://doi.org/10.1242%2Fjcs.115.1.9). [PMID](/source/PMID_(identifier)) [11801719](https://pubmed.ncbi.nlm.nih.gov/11801719).

- Jones JM, Meisler MH, Seldin MF, et al. (1992). "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7". *Genomics*. **14** (1): 197–9. [doi](/source/Doi_(identifier)):[10.1016/S0888-7543(05)80308-8](https://doi.org/10.1016%2FS0888-7543%2805%2980308-8). [hdl](/source/Hdl_(identifier)):[2027.42/29864](https://hdl.handle.net/2027.42%2F29864). [PMID](/source/PMID_(identifier)) [1358794](https://pubmed.ncbi.nlm.nih.gov/1358794).

- North MA, Naggert JK, Yan Y, et al. (1997). ["Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20333). *Proc. Natl. Acad. Sci. U.S.A*. **94** (7): 3128–33. [Bibcode](/source/Bibcode_(identifier)):[1997PNAS...94.3128N](https://ui.adsabs.harvard.edu/abs/1997PNAS...94.3128N). [doi](/source/Doi_(identifier)):[10.1073/pnas.94.7.3128](https://doi.org/10.1073%2Fpnas.94.7.3128). [PMC](/source/PMC_(identifier)) [20333](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20333). [PMID](/source/PMID_(identifier)) [9096357](https://pubmed.ncbi.nlm.nih.gov/9096357).

- Kapeller R, Moriarty A, Strauss A, et al. (1999). ["Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin"](https://doi.org/10.1074%2Fjbc.274.35.24980). *J. Biol. Chem*. **274** (35): 24980–6. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.35.24980](https://doi.org/10.1074%2Fjbc.274.35.24980). [PMID](/source/PMID_(identifier)) [10455176](https://pubmed.ncbi.nlm.nih.gov/10455176).

- Boggon TJ, Shan WS, Santagata S, et al. (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis". *Science*. **286** (5447): 2119–25. [doi](/source/Doi_(identifier)):[10.1126/science.286.5447.2119](https://doi.org/10.1126%2Fscience.286.5447.2119). [PMID](/source/PMID_(identifier)) [10591637](https://pubmed.ncbi.nlm.nih.gov/10591637). [S2CID](/source/S2CID_(identifier)) [33506220](https://api.semanticscholar.org/CorpusID:33506220).

- He W, Ikeda S, Bronson RT, et al. (2001). "GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members". *Brain Res. Mol. Brain Res*. **81** (1–2): 109–17. [doi](/source/Doi_(identifier)):[10.1016/S0169-328X(00)00164-9](https://doi.org/10.1016%2FS0169-328X%2800%2900164-9). [PMID](/source/PMID_(identifier)) [11000483](https://pubmed.ncbi.nlm.nih.gov/11000483).

- Santagata S, Boggon TJ, Baird CL, et al. (2001). "G-protein signaling through tubby proteins". *Science*. **292** (5524): 2041–50. [doi](/source/Doi_(identifier)):[10.1126/science.1061233](https://doi.org/10.1126%2Fscience.1061233). [PMID](/source/PMID_(identifier)) [11375483](https://pubmed.ncbi.nlm.nih.gov/11375483). [S2CID](/source/S2CID_(identifier)) [29856557](https://api.semanticscholar.org/CorpusID:29856557).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, et al. (2006). ["Identification of TUB as a novel candidate gene influencing body weight in humans"](https://doi.org/10.2337%2Fdiabetes.55.02.06.db05-0997). *Diabetes*. **55** (2): 385–9. [doi](/source/Doi_(identifier)):[10.2337/diabetes.55.02.06.db05-0997](https://doi.org/10.2337%2Fdiabetes.55.02.06.db05-0997). [hdl](/source/Hdl_(identifier)):[10029/7039](https://hdl.handle.net/10029%2F7039). [PMID](/source/PMID_(identifier)) [16443771](https://pubmed.ncbi.nlm.nih.gov/16443771).

- Giannaccini G, Giusti L, Santini F, et al. (2007). "Tubby protein in human lymphocytes from normal weight and obese subjects". *Clin. Biochem*. **40** (11): 806–9. [doi](/source/Doi_(identifier)):[10.1016/j.clinbiochem.2007.03.020](https://doi.org/10.1016%2Fj.clinbiochem.2007.03.020). [PMID](/source/PMID_(identifier)) [17498679](https://pubmed.ncbi.nlm.nih.gov/17498679).

## External links

- Overview of all the structural information available in the [PDB](/source/Protein_Data_Bank) for [UniProt](/source/UniProt): *[P50607](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P50607)* (Human Tubby protein homolog) at the [PDBe-KB](/source/PDBe-KB).

- Overview of all the structural information available in the [PDB](/source/Protein_Data_Bank) for [UniProt](/source/UniProt): *[P50586](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P50586)* (Mouse Tubby protein) at the [PDBe-KB](/source/PDBe-KB).

v t e PDB gallery 1c8z: C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN 1i7e: C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate 1s31: Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561

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