# TTI2

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**TELO2 interacting protein 2** is a [protein](/source/Protein) that is encoded by the TTI2 [gene](/source/Gene) in humans. [1]

## Function

This gene encodes a regulator of the [DNA damage response](/source/DNA-damage_response). The protein is a component of the Triple T complex (TTT) which also includes [telomere](/source/Telomere) length regulation protein and [TELO2](/source/TELO2) interacting protein 1.

The TTT complex is involved in cellular resistance to [DNA](/source/DNA) damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

## References

1. ["Entrez Gene: TELO2 interacting protein 2"](https://www.ncbi.nlm.nih.gov/gene/80185). Retrieved 2016-12-14.

## Further reading

- Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". *Genes Dev.*. **24** (17): 1939–50. [doi:10.1101/gad.1934210](https://doi.org/10.1101/gad.1934210). [PMC 2932975](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932975). [PMID 20810650](https://pubmed.ncbi.nlm.nih.gov/20810650)

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Adapted from the Wikipedia article [TTI2](https://en.wikipedia.org/wiki/TTI2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/TTI2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.