# TREML1

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**Trem-like transcript 1 protein** is a [protein](/source/Protein) that in humans is encoded by the *TREML1* [gene](/source/Gene).[1][2][3]

TREML1 is located in a gene cluster on [chromosome 6](/source/Chromosome_6) with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and [TREM2](/source/TREM2) (MIM 605086), but it has distinct structural and functional properties.

TREML1 enhances [calcium signaling](/source/Calcium_signaling) in an [SHP2](/source/Shp2) (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004).[supplied by OMIM][3]

## References

1. Washington AV, Quigley L, McVicar DW (Nov 2002). "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster". *Blood*. **100** (10): 3822–4. [doi:10.1182/blood-2002-02-0523](https://doi.org/10.1182/blood-2002-02-0523). [PMID 12393607](https://pubmed.ncbi.nlm.nih.gov/12393607)

1. Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (Mar 2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". *Eur J Immunol*. **33** (2): 567–77. [doi:10.1002/immu.200310033](https://doi.org/10.1002/immu.200310033). [PMID 12645956](https://pubmed.ncbi.nlm.nih.gov/12645956). [S2CID 27147251](https://api.semanticscholar.org/CorpusID:27147251)

1. ["Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=340205)

## Further reading

- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Gevaert K, Goethals M, Martens L, etal (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". *Nat. Biotechnol.*. **21** (5): 566–9. [doi:10.1038/nbt810](https://doi.org/10.1038/nbt810). [PMID 12665801](https://pubmed.ncbi.nlm.nih.gov/12665801). [S2CID 23783563](https://api.semanticscholar.org/CorpusID:23783563)
- Clark HF, Gurney AL, Abaya E, etal (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". *Genome Res.*. **13** (10): 2265–70. [doi:10.1101/gr.1293003](https://doi.org/10.1101/gr.1293003). [PMC 403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID 12975309](https://pubmed.ncbi.nlm.nih.gov/12975309)
- Mungall AJ, Palmer SA, Sims SK, etal (2003). "The DNA sequence and analysis of human chromosome 6.". *Nature*. **425** (6960): 805–11. [Bibcode:2003Natur.425..805M](https://ui.adsabs.harvard.edu/abs/2003Natur.425..805M). [doi:10.1038/nature02055](https://doi.org/10.1038/nature02055). [PMID 14574404](https://pubmed.ncbi.nlm.nih.gov/14574404)
- Washington AV, Schubert RL, Quigley L, etal (2005). "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.". *Blood*. **104** (4): 1042–7. [doi:10.1182/blood-2004-01-0315](https://doi.org/10.1182/blood-2004-01-0315). [PMID 15100151](https://pubmed.ncbi.nlm.nih.gov/15100151)
- Barrow AD, Astoul E, Floto A, etal (2004). "Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.". *J. Immunol.*. **172** (10): 5838–42. [doi:10.4049/jimmunol.172.10.5838](https://doi.org/10.4049/jimmunol.172.10.5838). [PMID 15128762](https://pubmed.ncbi.nlm.nih.gov/15128762)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Gattis JL, Washington AV, Chisholm MM, etal (2006). "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.". *J. Biol. Chem.*. **281** (19): 13396–403. [doi:10.1074/jbc.M600489200](https://doi.org/10.1074/jbc.M600489200). [PMID 16505478](https://pubmed.ncbi.nlm.nih.gov/16505478)
- Giomarelli B, Washington VA, Chisholm MM, etal (2007). ["Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1."](https://zenodo.org/record/1236186). *Thromb. Haemost.*. **97** (6): 955–63. [doi:10.1160/th06-08-0456](https://doi.org/10.1160/th06-08-0456). [PMID 17549298](https://pubmed.ncbi.nlm.nih.gov/17549298). [S2CID 22393896](https://api.semanticscholar.org/CorpusID:22393896)

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Adapted from the Wikipedia article [TREML1](https://en.wikipedia.org/wiki/TREML1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/TREML1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.