# TMEM127

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/TMEM127
> Markdown URL: https://mediated.wiki/source/TMEM127.md
> Source: https://en.wikipedia.org/wiki/TMEM127
> Source revision: 1091123499
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Transmembrane protein}}
{{#invoke:Infobox_gene|getTemplateData|QID=Q18041934}}

'''Transmembrane protein 127 (TMEM127)''' is a transmembrane protein which is encoded by the ''TMEM127'' gene.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/55654|title=TMEM127 transmembrane protein 127 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2018-03-09}}</ref> It has been demonstrated to be a negative regulator [MTOR](/source/MTOR) signalling.<ref name="Qin 2010">{{cite journal | vauthors = Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL | title = Germline mutations in TMEM127 confer susceptibility to pheochromocytoma | journal = Nature Genetics | volume = 42 | issue = 3 | pages = 229–33 | date = March 2010 | pmid = 20154675 | pmc = 2998199 | doi = 10.1038/ng.533 }}</ref> ''TMEM127'' is a [tumor suppressor gene](/source/tumor_suppressor_gene), inactivating [germline mutations](/source/Germline_mutation) in which causes hereditary [pheochromocytoma](/source/pheochromocytoma) and [paraganglioma](/source/paraganglioma).<ref name="Qin 2010" /><ref>{{cite journal | vauthors = Neumann HP, Sullivan M, Winter A, Malinoc A, Hoffmann MM, Boedeker CC, Bertz H, Walz MK, Moeller LC, Schmid KW, Eng C | title = Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadrenal abdominal sites | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 96 | issue = 8 | pages = E1279-82 | date = August 2011 | pmid = 21613359 | doi = 10.1210/jc.2011-0114 | doi-access = free }}</ref>

== References ==
{{Reflist}}

Category:Tumor suppressor genes

{{gene-2-stub}}

---
Adapted from the Wikipedia article [TMEM127](https://en.wikipedia.org/wiki/TMEM127) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/TMEM127?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.