# TLE3

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Protein-coding gene in the species Homo sapiens

TLE3 Identifiers Aliases TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor External IDs OMIM: 600190; MGI: 104634; HomoloGene: 21059; GeneCards: TLE3; OMA:TLE3 - orthologs Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 70,047,790 bp[1] End 70,098,176 bp[1] Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 61,279,648 bp[2] End 61,325,779 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood ganglionic eminence sural nerve ventricular zone skin of leg buccal mucosa cell right testis monocyte left testis skin of abdomen Top expressed in genital tubercle Rostral migratory stream tail of embryo granulocyte decidua ventricular zone hair follicle lacrimal gland intestinal villus molar More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding transcription corepressor activity Cellular component nucleus nucleoplasm beta-catenin-TCF complex transcription regulator complex Biological process animal organ morphogenesis regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated signal transduction beta-catenin-TCF complex assembly negative regulation of canonical Wnt signaling pathway negative regulation of cold-induced thermogenesis negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 7090 21887 Ensembl ENSG00000140332 ENSMUSG00000032280 UniProt Q04726 Q6PRX3 Q08122 RefSeq (mRNA) NM_001105192 NM_001282979 NM_001282980 NM_001282981 NM_001282982 NM_005078 NM_020908 NM_001083927 NM_001083928 NM_009389 RefSeq (protein) NP_001098662 NP_001269908 NP_001269909 NP_001269910 NP_001269911 NP_005069 NP_065959 NP_001269908.1 NP_001077396 NP_001077397 NP_033415 Location (UCSC) Chr 15: 70.05 – 70.1 Mb Chr 9: 61.28 – 61.33 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Transducin-like enhancer protein 3** is a [protein](/source/Protein) that in humans is encoded by the *TLE3* [gene](/source/Gene).[5][6]

TLE3 expression has been linked to higher survival rates for [lung cancer](/source/Lung_cancer) patients.[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000140332](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000140332) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000032280](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000032280) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7090). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=21887). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8365415_5-0)** Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). ["Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein"](https://doi.org/10.1111%2Fj.1432-1033.1993.tb18151.x). *European Journal of Biochemistry*. **216** (1): 343–52. [doi](/source/Doi_(identifier)):[10.1111/j.1432-1033.1993.tb18151.x](https://doi.org/10.1111%2Fj.1432-1033.1993.tb18151.x). [PMID](/source/PMID_(identifier)) [8365415](https://pubmed.ncbi.nlm.nih.gov/8365415).

1. **[^](#cite_ref-entrez_6-0)** ["Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7090).

1. **[^](#cite_ref-7)** ["Research update from the MCM team (February 2024)"](https://www.worldcommunitygrid.org/about_us/article.s?articleId=807). World Community Grid. 16 February 2024. Retrieved 21 May 2024.

## Further reading

- Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (Oct 1992). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". *Nature Genetics*. **2** (2): 119–27. [doi](/source/Doi_(identifier)):[10.1038/ng1092-119](https://doi.org/10.1038%2Fng1092-119). [PMID](/source/PMID_(identifier)) [1303260](https://pubmed.ncbi.nlm.nih.gov/1303260). [S2CID](/source/S2CID_(identifier)) [32142845](https://api.semanticscholar.org/CorpusID:32142845).

- Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). ["Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia"](https://doi.org/10.1006%2Fgeno.1996.0009). *Genomics*. **31** (1): 58–64. [doi](/source/Doi_(identifier)):[10.1006/geno.1996.0009](https://doi.org/10.1006%2Fgeno.1996.0009). [PMID](/source/PMID_(identifier)) [8808280](https://pubmed.ncbi.nlm.nih.gov/8808280).

- Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (Jun 2000). ["Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta"](https://doi.org/10.1074%2Fjbc.M910211199). *The Journal of Biological Chemistry*. **275** (24): 18418–23. [doi](/source/Doi_(identifier)):[10.1074/jbc.M910211199](https://doi.org/10.1074%2Fjbc.M910211199). [PMID](/source/PMID_(identifier)) [10748198](https://pubmed.ncbi.nlm.nih.gov/10748198).

- Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). ["Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"](https://doi.org/10.1093%2Fdnares%2F7.4.271). *DNA Research*. **7** (4): 273–81. [doi](/source/Doi_(identifier)):[10.1093/dnares/7.4.271](https://doi.org/10.1093%2Fdnares%2F7.4.271). [PMID](/source/PMID_(identifier)) [10997877](https://pubmed.ncbi.nlm.nih.gov/10997877).

- Yao J, Lai E, Stifani S (Mar 2001). ["The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86788). *Molecular and Cellular Biology*. **21** (6): 1962–72. [doi](/source/Doi_(identifier)):[10.1128/MCB.21.6.1962-1972.2001](https://doi.org/10.1128%2FMCB.21.6.1962-1972.2001). [PMC](/source/PMC_(identifier)) [86788](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86788). [PMID](/source/PMID_(identifier)) [11238932](https://pubmed.ncbi.nlm.nih.gov/11238932).

- Nuthall HN, Joachim K, Palaparti A, Stifani S (Dec 2002). ["A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression"](https://doi.org/10.1074%2Fjbc.M111660200). *The Journal of Biological Chemistry*. **277** (52): 51049–57. [doi](/source/Doi_(identifier)):[10.1074/jbc.M111660200](https://doi.org/10.1074%2Fjbc.M111660200). [PMID](/source/PMID_(identifier)) [12397081](https://pubmed.ncbi.nlm.nih.gov/12397081).

- López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P (Jan 2003). ["Six3 and Six6 activity is modulated by members of the groucho family"](https://doi.org/10.1242%2Fdev.00185). *Development*. **130** (1): 185–95. [doi](/source/Doi_(identifier)):[10.1242/dev.00185](https://doi.org/10.1242%2Fdev.00185). [PMID](/source/PMID_(identifier)) [12441302](https://pubmed.ncbi.nlm.nih.gov/12441302).

- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). ["Large-scale characterization of HeLa cell nuclear phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). *Proceedings of the National Academy of Sciences of the United States of America*. **101** (33): 12130–5. [Bibcode](/source/Bibcode_(identifier)):[2004PNAS..10112130B](https://ui.adsabs.harvard.edu/abs/2004PNAS..10112130B). [doi](/source/Doi_(identifier)):[10.1073/pnas.0404720101](https://doi.org/10.1073%2Fpnas.0404720101). [PMC](/source/PMC_(identifier)) [514446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). [PMID](/source/PMID_(identifier)) [15302935](https://pubmed.ncbi.nlm.nih.gov/15302935).

- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nature Biotechnology*. **24** (10): 1285–92. [doi](/source/Doi_(identifier)):[10.1038/nbt1240](https://doi.org/10.1038%2Fnbt1240). [PMID](/source/PMID_(identifier)) [16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID](/source/S2CID_(identifier)) [14294292](https://api.semanticscholar.org/CorpusID:14294292).

- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). ["Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"](https://doi.org/10.1016%2Fj.cell.2006.09.026). *Cell*. **127** (3): 635–48. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2006.09.026](https://doi.org/10.1016%2Fj.cell.2006.09.026). [PMID](/source/PMID_(identifier)) [17081983](https://pubmed.ncbi.nlm.nih.gov/17081983).

- Tu LC, Yan X, Hood L, Lin B (Apr 2007). ["Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells"](https://doi.org/10.1074%2Fmcp.M600249-MCP200). *Molecular & Cellular Proteomics*. **6** (4): 575–88. [doi](/source/Doi_(identifier)):[10.1074/mcp.M600249-MCP200](https://doi.org/10.1074%2Fmcp.M600249-MCP200). [PMID](/source/PMID_(identifier)) [17220478](https://pubmed.ncbi.nlm.nih.gov/17220478).

- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). ["Large-scale mapping of human protein-protein interactions by mass spectrometry"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). *Molecular Systems Biology*. **3** (1) 89. [doi](/source/Doi_(identifier)):[10.1038/msb4100134](https://doi.org/10.1038%2Fmsb4100134). [PMC](/source/PMC_(identifier)) [1847948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). [PMID](/source/PMID_(identifier)) [17353931](https://pubmed.ncbi.nlm.nih.gov/17353931).

v t e PDB gallery 1gxr: WD40 REGION OF HUMAN GROUCHO/TLE1 2ce8: AN EH1 PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN. 2ce9: A WRPW PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN.

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