# TIE1

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TIE1 Identifiers Aliases TIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11 External IDs OMIM: 600222; MGI: 99906; HomoloGene: 3957; GeneCards: TIE1; OMA:TIE1 - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 43,300,982 bp[1] End 43,323,108 bp[1] Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.1|4 54.67 cM Start 118,328,388 bp[2] End 118,347,258 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung upper lobe of left lung right lobe of thyroid gland subcutaneous adipose tissue left lobe of thyroid gland body of uterus left ventricle right auricle of heart tibial nerve Top expressed in cardiac muscle tissue of left ventricle left lung ankle joint right lung interventricular septum left lung lobe right lung lobe yolk sac atrium vein More reference expression data BioGPS n/a Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cytoplasm receptor complex Biological process plasma membrane fusion response to retinoic acid phosphorylation in utero embryonic development vasculogenesis protein phosphorylation negative regulation of cell migration blood vessel development angiogenesis negative regulation of angiogenesis mesoderm development signal transduction peptidyl-tyrosine phosphorylation negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of angiogenesis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 7075 21846 Ensembl ENSG00000066056 ENSMUSG00000033191 UniProt P35590 Q06806 RefSeq (mRNA) NM_001253357 NM_005424 NM_011587 RefSeq (protein) NP_001240286 NP_005415 NP_035717 Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.33 – 118.35 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE, JTK14 NCBI gene 7075 HGNC 11809 OMIM 600222 RefSeq NM_005424 UniProt P35590 Other data EC number 2.7.1.112 Locus Chr. 1 p34-p33 Search for Structures Swiss-model Domains InterPro

**Tyrosine kinase with immunoglobulin-like and EGF-like domains 1** also known as **TIE1** is an [angiopoietin receptor](/source/Angiopoietin_receptor) which in humans is encoded by the *TIE1* [gene](/source/Gene).[5]

## Function

TIE1 is a cell surface protein expressed exclusively in [endothelial](/source/Endothelium) cells, however it has also been shown to be expressed in immature [hematopoietic cells](https://en.wikipedia.org/w/index.php?title=Hematopoietic_cells&action=edit&redlink=1)[6] and platelets.[7] TIE1 upregulates the [cell adhesion molecules](/source/Cell_adhesion_molecule) (CAMs) [VCAM-1](/source/VCAM-1), [E-selectin](/source/E-selectin), and [ICAM-1](/source/ICAM-1) through a [p38](/source/P38_mitogen-activated_protein_kinases)-dependent mechanism. Attachment of [monocyte](/source/Monocyte) derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as [atherosclerosis](/source/Atherosclerosis).[8]

## See also

- [Angiopoietin § Tie pathway](/source/Angiopoietin#Tie_pathway)

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000066056](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000066056) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000033191](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000033191) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7075). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=21846). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid1312667_5-0)** Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). ["A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369613). *Molecular and Cellular Biology*. **12** (4): 1698–707. [doi](/source/Doi_(identifier)):[10.1128/mcb.12.4.1698](https://doi.org/10.1128%2Fmcb.12.4.1698). [PMC](/source/PMC_(identifier)) [369613](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369613). [PMID](/source/PMID_(identifier)) [1312667](https://pubmed.ncbi.nlm.nih.gov/1312667).

1. **[^](#cite_ref-6)** Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". *Oncogene*. **12** (2): 397–404. [PMID](/source/PMID_(identifier)) [8570217](https://pubmed.ncbi.nlm.nih.gov/8570217).

1. **[^](#cite_ref-pmid11146396_7-0)** Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". *Journal of Vascular Research*. **37** (6): 437–42. [doi](/source/Doi_(identifier)):[10.1159/000054075](https://doi.org/10.1159%2F000054075). [hdl](/source/Hdl_(identifier)):[2381/22424](https://hdl.handle.net/2381%2F22424). [PMID](/source/PMID_(identifier)) [11146396](https://pubmed.ncbi.nlm.nih.gov/11146396). [S2CID](/source/S2CID_(identifier)) [43509019](https://api.semanticscholar.org/CorpusID:43509019).

1. **[^](#cite_ref-pmid18448073_8-0)** Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". *Biochemical and Biophysical Research Communications*. **371** (3): 475–9. [Bibcode](/source/Bibcode_(identifier)):[2008BBRC..371..475C](https://ui.adsabs.harvard.edu/abs/2008BBRC..371..475C). [doi](/source/Doi_(identifier)):[10.1016/j.bbrc.2008.04.091](https://doi.org/10.1016%2Fj.bbrc.2008.04.091). [PMID](/source/PMID_(identifier)) [18448073](https://pubmed.ncbi.nlm.nih.gov/18448073).

## External links

- [Receptor,+TIE-1](https://meshb.nlm.nih.gov/record/ui?name=Receptor%2C+TIE-1) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

v t e Protein kinases: tyrosine kinases (EC 2.7.10) Receptor tyrosine kinases (EC 2.7.10.1) Growth factor receptors EGF receptor family EGFR ERBB2 ERBB3 ERBB4 Insulin receptor family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR PDGFRA PDGFRB FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptor family VEGFR1 VEGFR2 VEGFR3 HGF receptor family MET RON Trk receptor family NTRK1 NTRK2 NTRK3 EPH receptor family EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB5 EPHB6 EPHX LTK receptor family LTK ALK TIE receptor family TIE TEK ROR receptor family ROR1 ROR2 DDR receptor family DDR1 DDR2 PTK7 receptor family PTK7 RYK receptor family RYK MuSK receptor family MUSK ROS receptor family ROS1 AATYK receptor family AATYK AATYK2 AXL receptor family AXL MER TYRO3 RET receptor family RET uncategorised STYK1 Non-receptor tyrosine kinases (EC 2.7.10.2) ABL family ABL1 ARG ACK family ACK1 TNK1 CSK family CSK MATK FAK family FAK PYK2 FES family FES FER FRK family FRK BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70

v t e Enzymes Activity Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis Regulation Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator Classification EC number Enzyme superfamily Enzyme family List of enzymes Kinetics Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics Types EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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