# TAX1BP3

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/TAX1BP3
> Markdown URL: https://mediated.wiki/source/TAX1BP3.md
> Source: https://en.wikipedia.org/wiki/TAX1BP3
> Source revision: 1300577446
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in the species Homo sapiens

TAX1BP3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KG2, 2L4S, 2L4T, 2VZ5, 3GJ9, 3SFJ, 4E3B, 4NNL, 4NNM Identifiers Aliases TAX1BP3, TIP-1, TIP1, Tax1 binding protein 3 External IDs OMIM: 616484; MGI: 1923531; HomoloGene: 8749; GeneCards: TAX1BP3; OMA:TAX1BP3 - orthologs Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,662,895 bp[1] End 3,668,679 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 73,067,909 bp[2] End 73,073,988 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve apex of heart mucosa of esophagus canal of the cervix mucosa of transverse colon ectocervix vagina right auricle of heart left ventricle left coronary artery Top expressed in ileum jejunum stomach blastocyst colon urinary bladder yolk sac neural tube white adipose tissue lung More reference expression data BioGPS n/a Gene ontology Molecular function beta-catenin binding protein C-terminus binding protein binding Cellular component cytoplasm cytosol plasma membrane extracellular exosome membrane nucleus fibrillar center actin cytoskeleton intracellular membrane-bounded organelle Biological process negative regulation of Wnt signaling pathway negative regulation of protein localization to cell surface regulation of Wnt signaling pathway Wnt signaling pathway Rho protein signal transduction activation of GTPase activity negative regulation of cell population proliferation Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 30851 76281 Ensembl ENSG00000213977 ENSMUSG00000040158 UniProt O14907 Q9DBG9 RefSeq (mRNA) NM_014604 NM_001204698 NM_029564 RefSeq (protein) NP_001191627 NP_055419 NP_083840 Location (UCSC) Chr 17: 3.66 – 3.67 Mb Chr 11: 73.07 – 73.07 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Tax1-binding protein 3** is a [protein](/source/Protein) that in humans is encoded by the *TAX1BP3* [gene](/source/Gene).[5][6][7] This name is in reference to the [Tax1](/source/Tax1) protein of the [Human T-cell Lymphotropic Virus](/source/Human_T-lymphotropic_virus) (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by [co-IP](/source/Co-IP). TIP1, as it is also known, is a [PDZ domain](/source/PDZ_domain) containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an [inhibitor](/source/Enzyme_inhibitor), either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the [cytosol](/source/Cytosol).

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000213977](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000213977) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000040158](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000040158) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=30851). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=76281). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8619474_5-0)** Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". *Anal Biochem*. **236** (1): 107–113. [doi](/source/Doi_(identifier)):[10.1006/abio.1996.0138](https://doi.org/10.1006%2Fabio.1996.0138). [PMID](/source/PMID_(identifier)) [8619474](https://pubmed.ncbi.nlm.nih.gov/8619474).

1. **[^](#cite_ref-pmid10673275_6-0)** Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED (Mar 2000). ["The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310836). *Genome Res*. **10** (2): 165–173. [doi](/source/Doi_(identifier)):[10.1101/gr.10.2.165](https://doi.org/10.1101%2Fgr.10.2.165). [PMC](/source/PMC_(identifier)) [310836](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310836). [PMID](/source/PMID_(identifier)) [10673275](https://pubmed.ncbi.nlm.nih.gov/10673275).

1. **[^](#cite_ref-entrez_7-0)** ["Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=30851).

## Further reading

- Banerjee M, et al. (2012). ["Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433589). *Biochemistry*. **51** (35): 6950–6960. [doi](/source/Doi_(identifier)):[10.1021/bi3008033](https://doi.org/10.1021%2Fbi3008033). [PMC](/source/PMC_(identifier)) [3433589](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433589). [PMID](/source/PMID_(identifier)) [22876914](https://pubmed.ncbi.nlm.nih.gov/22876914).

- Rousset R, Fabre S, Desbois C, et al. (1998). ["The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins"](https://doi.org/10.1038%2Fsj.onc.1201567). *Oncogene*. **16** (5): 643–654. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1201567](https://doi.org/10.1038%2Fsj.onc.1201567). [PMID](/source/PMID_(identifier)) [9482110](https://pubmed.ncbi.nlm.nih.gov/9482110).

- Reynaud C, Fabre S, Jalinot P (2000). ["The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element"](https://doi.org/10.1074%2Fjbc.M000465200). *J. Biol. Chem*. **275** (43): 33962–33968. [doi](/source/Doi_(identifier)):[10.1074/jbc.M000465200](https://doi.org/10.1074%2Fjbc.M000465200). [PMID](/source/PMID_(identifier)) [10940294](https://pubmed.ncbi.nlm.nih.gov/10940294).

- Olalla L, Aledo JC, Bannenberg G, Márquez J (2001). "The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins". *FEBS Lett*. **488** (3): 116–122. [doi](/source/Doi_(identifier)):[10.1016/S0014-5793(00)02373-5](https://doi.org/10.1016%2FS0014-5793%2800%2902373-5). [PMID](/source/PMID_(identifier)) [11163757](https://pubmed.ncbi.nlm.nih.gov/11163757). [S2CID](/source/S2CID_(identifier)) [11614189](https://api.semanticscholar.org/CorpusID:11614189).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–16903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Kanamori M, Sandy P, Marzinotto S, et al. (2003). ["The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells"](https://doi.org/10.1074%2Fjbc.M306324200). *J. Biol. Chem*. **278** (40): 38758–38764. [doi](/source/Doi_(identifier)):[10.1074/jbc.M306324200](https://doi.org/10.1074%2Fjbc.M306324200). [PMID](/source/PMID_(identifier)) [12874278](https://pubmed.ncbi.nlm.nih.gov/12874278).

- Twizere JC, Kruys V, Lefèbvre L, et al. (2004). ["Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression"](https://doi.org/10.1093%2Fjnci%2Fdjg118). *J. Natl. Cancer Inst*. **95** (24): 1846–1859. [doi](/source/Doi_(identifier)):[10.1093/jnci/djg118](https://doi.org/10.1093%2Fjnci%2Fdjg118). [PMID](/source/PMID_(identifier)) [14679154](https://pubmed.ncbi.nlm.nih.gov/14679154).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–45. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–2127. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Hampson L, Li C, Oliver AW, et al. (2005). "The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein". *Int. J. Oncol*. **25** (5): 1249–1256. [doi](/source/Doi_(identifier)):[10.3892/ijo.25.5.1249](https://doi.org/10.3892%2Fijo.25.5.1249). [PMID](/source/PMID_(identifier)) [15492812](https://pubmed.ncbi.nlm.nih.gov/15492812).

- Alewine C, Olsen O, Wade JB, Welling PA (2007). ["TIP-1 has PDZ scaffold antagonist activity"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635354). *Mol. Biol. Cell*. **17** (10): 4200–4211. [doi](/source/Doi_(identifier)):[10.1091/mbc.E06-02-0129](https://doi.org/10.1091%2Fmbc.E06-02-0129). [PMC](/source/PMC_(identifier)) [1635354](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635354). [PMID](/source/PMID_(identifier)) [16855024](https://pubmed.ncbi.nlm.nih.gov/16855024).

This protein-related article is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Protein-stub)
- [t](/source/Template_talk%3AProtein-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Protein-stub)

---
Adapted from the Wikipedia article [TAX1BP3](https://en.wikipedia.org/wiki/TAX1BP3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/TAX1BP3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.