# SprX small RNA

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In molecular biology the **small pathogenicity island RNA X** (alias RsaOR) gene is a bacterial [non-coding RNA](/source/Non-coding_RNA). It was discovered in a large-scale analysis of *[Staphylococcus aureus](/source/Staphylococcus_aureus)*.[1] SprX was shown to influence [antibiotic resistance](/source/Antimicrobial_resistance) of the bacteria to [Vancomycin](/source/Vancomycin) and [Teicoplanin](/source/Teicoplanin) [glycopeptides](/source/Glycopeptide), which are used to treat [MRSA](/source/Methicillin-resistant_Staphylococcus_aureus) infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects *S. aureus* resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.[3]

## See also

- [SprD](/source/SprD)

## References

1. Bohn C, Rigoulay C, Chabelskaya S, Sharma CM, Marchais A, Skorski P, Borezée-Durant E, Barbet R, Jacquet E, Jacq A, Gautheret D, Felden B, Vogel J, Bouloc P (October 2010). "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". *Nucleic Acids Research*. **38** (19): 6620–36. [doi:10.1093/nar/gkq462](https://doi.org/10.1093/nar/gkq462). [PMC 2965222](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965222). [PMID 20511587](https://pubmed.ncbi.nlm.nih.gov/20511587)

1. Eyraud A, Tattevin P, Chabelskaya S, Felden B (April 2014). "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". *Nucleic Acids Research*. **42** (8): 4892–905. [doi:10.1093/nar/gku149](https://doi.org/10.1093/nar/gku149). [PMC 4005690](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005690). [PMID 24557948](https://pubmed.ncbi.nlm.nih.gov/24557948)

1. Kathirvel M, Buchad H, Nair M (December 2016). "Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1". *Medical Microbiology and Immunology*. **205** (6): 563–574. [doi:10.1007/s00430-016-0467-9](https://doi.org/10.1007/s00430-016-0467-9). [PMID 27438010](https://pubmed.ncbi.nlm.nih.gov/27438010). [S2CID 15284645](https://api.semanticscholar.org/CorpusID:15284645)

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