# SplitsTree

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> Source: https://en.wikipedia.org/wiki/SplitsTree
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{{Short description|Software for inferring bioinformatics split graphs}}
{{Infobox software
| name = SplitsTree
| logo = 
| screenshot = 
| caption = 
| developer = Daniel Huson and David Bryant
| latest release version = 4.17.1
| latest release date = 2021
| latest preview version = 5.3
| latest preview date = 2021
| operating system = Windows, Linux, Mac OS X
| platform = 
| genre = [Bioinformatics](/source/Bioinformatics)
| license = Proprietary
| website = {{URL|https://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/informatik/lehrstuehle/algorithms-in-bioinformatics/software/splitstree/}}
}}
[[File:Heterobranchia tree.png|right|thumb|An example of a [neighbor-net](/source/neighbor-net) [phylogenetic network](/source/phylogenetic_network) generated by SplitsTree v4.6.]]
'''SplitsTree''' is a [freeware](/source/freeware) program for inferring [phylogenetic tree](/source/phylogenetic_tree)s, [phylogenetic network](/source/phylogenetic_network)s, or, more generally, [split graphs](/source/split_graphs), from various types of data such as a [sequence alignment](/source/sequence_alignment), a [distance matrix](/source/distance_matrix) or a set of trees.<ref name="dhm2001">{{cite journal |last=Dress |first=A. |author2=K. T. Huber|author2-link=Katharina T. Huber |author3=V. Moulton  |year=2001 |title= Metric spaces in pure and applied mathematics |journal= Documenta Mathematica |series=Documenta Mathematica Series |volume=2 |pages=121–139 |doi=10.4171/dms/2/5 |doi-access=free |isbn=978-3-98547-042-6 |url=http://www.emis.de/journals/DMJDMV/lsu/dress-huber-multon.pdf }}</ref><ref name="hb2006">{{cite journal |last=Huson |first=D. H. |author2=D. Bryant  |year=2006 |title= Application of Phylogenetic Networks in Evolutionary Studies |journal=Mol. Biol. Evol. |volume=23 |issue=2 |pages= 254–267 | doi=10.1093/molbev/msj030 |pmid=16221896 |doi-access=free }}</ref>

==Software==
SplitsTree implements published methods such as [split](/source/split_(phylogenetics)) decomposition,<ref>{{Cite journal|last1=Bandelt|first1=H. J.|last2=Dress|first2=A. W.|year=1992|title=Split decomposition: a new and useful approach to phylogenetic analysis of distance data|journal=Molecular Phylogenetics and Evolution|volume=1|issue=3|pages=242–252|doi=10.1016/1055-7903(92)90021-8|issn=1055-7903|pmid=1342941|bibcode=1992MolPE...1..242B }}</ref> [neighbor-net](/source/neighbor-net), consensus networks,<ref>{{Cite book|last1=Holland|first1=Barbara|last2=Moulton|first2=Vincent|date=2003|editor-last=Benson|editor-first=Gary|editor2-last=Page|editor2-first=Roderic D. M.|chapter=Consensus Networks: A Method for Visualising Incompatibilities in Collections of Trees|title=Algorithms in Bioinformatics|volume=2812|series=Lecture Notes in Computer Science|language=en|publisher=Springer Berlin Heidelberg|pages=165–176|doi=10.1007/978-3-540-39763-2_13|isbn=9783540397632}}</ref> super networks methods or methods for computing [hybridization](/source/Hybrid_(biology)) or simple [recombination](/source/genetic_recombination) networks. It uses the [NEXUS file format](/source/Nexus_file). The splits graph is defined using a special data block (SPLITS block).

== See also ==
*[Phylogenetic tree viewers](/source/Phylogenetic_tree_viewers)
*[Dendroscope](/source/Dendroscope)
*[MEGAN](/source/MEGAN)

== References ==
{{Reflist}}

== External links ==
*[https://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/informatik/lehrstuehle/algorithms-in-bioinformatics/software/splitstree/ SplitsTree homepage] (New Website for informations about SplitsTree)
*[https://software-ab.informatik.uni-tuebingen.de/download/splitstree4/welcome.html Alternative download page] for the latest version (4.15) and manual (June 2019), hosted by the [https://uni-tuebingen.de/en/faculties/faculty-of-science/departments/computer-science/department/ Department of Computer Science] at the [Eberhard Karls University Tübingen](/source/University_of_T%C3%BCbingen)
*[https://uni-tuebingen.de/en/faculties/faculty-of-science/departments/computer-science/lehrstuehle/algorithmen-der-bioinformatik/ Algorithms in Bioinformatics], Daniel Huson's working group developing SplitsTree and other bioinformatics software
*[http://evolution.genetics.washington.edu/phylip/software.html List of phylogeny software], hosted at the University of Washington
*[http://phylonetworks.blogspot.com/ The Genealogical World of Phylogenetic Networks] provides a wide range of examples for splits graphs, most of which were generated with SplitsTree
*[https://phylnet.univ-mlv.fr/ Who is Who in Phylogenetic Networks] lists software, researchers and literature dealing with phylogenetic networks

Category:Phylogenetics software

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Adapted from the Wikipedia article [SplitsTree](https://en.wikipedia.org/wiki/SplitsTree) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SplitsTree?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.