# Selected ion monitoring

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**Selected ion monitoring** (**SIM**) is a [mass spectrometry](/source/Mass_spectrometry) scanning mode in which only a limited [mass-to-charge ratio](/source/Mass-to-charge_ratio) range is transmitted/detected by the instrument, as opposed to the full [spectrum](/source/Mass_spectrum) range.[1][2][3][4] This mode of operation typically results in significantly increased sensitivity. Due to their inherent nature, this technique is most effective—and therefore most common—on [quadrupole mass spectrometers](/source/Quadrupole_mass_analyzers), [Orbitrap](/source/Orbitrap), and [Fourier transform ion cyclotron resonance mass spectrometers](/source/Fourier_transform_ion_cyclotron_resonance_mass_spectrometers).

## See also

- [Selected reaction monitoring](/source/Selected_reaction_monitoring)

## References

1. Murray, Kermit K.; Boyd, Robert K.; Eberlin, Marcos N.; Langley, G. John; Li, Liang; Naito, Yasuhide (2013). "Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)". *Pure and Applied Chemistry*. **85** (7): 1515–1609. [doi:10.1351/PAC-REC-06-04-06](https://doi.org/10.1351/PAC-REC-06-04-06). [ISSN 0033-4545](https://www.worldcat.org/issn/0033-4545)

1. Kaufmann, Anton (2018). ["Analytical performance of the various acquisition modes in Orbitrap MS and MS/MS"](https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4195). *Journal of Mass Spectrometry*. **53** (8): 725–738. [Bibcode:2018JMSp...53..725K](https://ui.adsabs.harvard.edu/abs/2018JMSp...53..725K). [doi:10.1002/jms.4195](https://doi.org/10.1002/jms.4195). [ISSN 1076-5174](https://www.worldcat.org/issn/1076-5174). [PMID 29708288](https://pubmed.ncbi.nlm.nih.gov/29708288)

1. Lu, Wenyun; McBride, Matthew J.; Lee, Won Dong; Xing, Xi; Xu, Xincheng; Li, Xi; Oschmann, Anna M.; Shen, Yihui; Bartman, Caroline; Rabinowitz, Joshua D. (2024). "Selected Ion Monitoring for Orbitrap-Based Metabolomics". *Metabolites*. **14** (4): 184. [doi:10.3390/metabo14040184](https://doi.org/10.3390/metabo14040184). [ISSN 2218-1989](https://www.worldcat.org/issn/2218-1989). [PMC 11051813](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11051813)

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