# Sarcotoxin

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**Sarcotoxins** are a group of [antibacterial peptides](/source/Antibacterial_peptides) present in the flesh fly belonging to the genus *[Sarcophaga](/source/Sarcophaga)*. The proteins are present in the haemolymph of the flesh fly. The first protein, called sarcotoxin IA, was discovered in 1983 from *[Sarcophaga peregrina](/source/Sarcophaga_peregrina)* by Masayuki Okada and Shunji Natori at the University of Tokyo, Japan.[1][2]

The name sarcotoxin is derived from the peptide's discovery in *Sarcophaga* flies, and so antibacterial compounds were given the name sarcotoxin and an identifying number or letter. However, many sarcotoxins are homologues of [cecropins](/source/Cecropin) or [attacins](/source/Attacin), and are not unique to *Sarcophaga* flies.[3][4]

## References

1. Iwai, H.; Nakajima, Y.; Natori, S.; Arata, Y.; Shimada, I. (Oct 1993). "Solution conformation of an antibacterial peptide, sarcotoxin IA, as determined by 1H-NMR.". *Eur J Biochem*. **217** (2): 639–44. [doi:10.1111/j.1432-1033.1993.tb18287.x](https://doi.org/10.1111/j.1432-1033.1993.tb18287.x). [PMID 8223606](https://pubmed.ncbi.nlm.nih.gov/8223606)

1. Okada M, Natori S (1984). "Mode of action of a bactericidal protein induced in the haemolymph of *Sarcophaga peregrina* (flesh-fly) larvae". *Biochem J*. **222** (1): 119–124. [doi:10.1042/bj2220119](https://doi.org/10.1042/bj2220119). [PMC 1144151](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144151). [PMID 6383355](https://pubmed.ncbi.nlm.nih.gov/6383355)

1. ["Sarcotoxin II-3 precursor - Sarcophaga peregrina (Flesh fly)"](https://www.uniprot.org/uniprot/P24490). *www.uniprot.org*. Retrieved 2021-02-02.

1. ["Sarcotoxin-1A precursor - Sarcophaga peregrina (Flesh fly)"](https://www.uniprot.org/uniprot/P08375). *www.uniprot.org*. Retrieved 2021-02-02.

## External links

- [Description at COPE](http://www.copewithcytokines.de/cope.cgi?key=sarcotoxins)
- [UniProt database](https://www.uniprot.org/uniprot/?query=sarcotoxin&sort=score)

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Adapted from the Wikipedia article [Sarcotoxin](https://en.wikipedia.org/wiki/Sarcotoxin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Sarcotoxin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.