# Sarcoglycan

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Sarcoglycan
> Markdown URL: https://mediated.wiki/source/Sarcoglycan.md
> Source: https://en.wikipedia.org/wiki/Sarcoglycan
> Source revision: 1300239376
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Pfam_box
| Symbol = Sarcoglycan_1
| Name = Sarcoglycan beta/gamma/delta
| image = 
| width = 
| caption = 
| Pfam = PF04790
| InterPro = IPR006875
| SMART = 
| PROSITE = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| PDB = 
| Membranome superfamily = 117
}}
{{Pfam_box
| Symbol = Sarcoglycan_2
| Name = Sarcoglycan alpha/epsilon
| image = 
| width = 
| caption = 
| Pfam = PF05510
| InterPro = IPR008908
| SMART = 
| PROSITE = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| PDB = 
}}
The '''sarcoglycans''' are a family of [transmembrane protein](/source/transmembrane_protein)s<ref>{{MeshName|Sarcoglycans}}</ref> (α, β, γ, δ or ε) involved in the [protein complex](/source/protein_complex) responsible for connecting the muscle fibre [cytoskeleton](/source/cytoskeleton) to the [extracellular matrix](/source/extracellular_matrix), preventing damage to the muscle fibre [sarcolemma](/source/sarcolemma) through shearing forces.

The [dystrophin](/source/dystrophin) glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The '''sarcoglycan complex''' is a subcomplex within the DGC and is composed of six muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-sarcoglycan).<ref name="NIH">{{cite web |title=SGCZ sarcoglycan zeta [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=137868 |website=www.ncbi.nlm.nih.gov |access-date=1 December 2021}}</ref> The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.<ref name="PUB00008631">{{cite journal | vauthors = Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB | title = Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy | journal = American Journal of Physiology. Cell Physiology | volume = 283 | issue = 2 | pages = C500-11 | date = August 2002 | pmid = 12107060 | doi = 10.1152/ajpcell.00529.2001 }}</ref><ref name="PUB00008632">{{cite journal | vauthors = Wheeler MT, Zarnegar S, McNally EM | title = Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy | journal = Human Molecular Genetics | volume = 11 | issue = 18 | pages = 2147–54 | date = September 2002 | pmid = 12189167 | doi = 10.1093/hmg/11.18.2147 | doi-access = free }}</ref>

The disorders caused by the mutations of the sarcoglycans are called [sarcoglycanopathies](/source/sarcoglycanopathies). Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated [limb-girdle muscular dystrophy](/source/limb-girdle_muscular_dystrophy).

==Genes==
* [SGCA](/source/SGCA)
* [SGCB](/source/SGCB)
* [SGCD](/source/Delta-sarcoglycan)
* [SGCE](/source/SGCE)
* [SGCG](/source/SGCG)
* [SGCZ](/source/SGCZ)

== References ==
{{reflist}}

{{Muscle tissue}}

{{InterPro content|IPR006875}}

Category:Protein families

{{protein-stub}}

---
Adapted from the Wikipedia article [Sarcoglycan](https://en.wikipedia.org/wiki/Sarcoglycan) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Sarcoglycan?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.