# SVIL

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Supervillin''' is a [protein](/source/protein) that in humans is encoded by the ''SVIL'' [gene](/source/gene).<ref name="pmid9382871">{{cite journal | vauthors = Pestonjamasp KN, Pope RK, Wulfkuhle JD, Luna EJ | title = Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily | journal = The Journal of Cell Biology | volume = 139 | issue = 5 | pages = 1255–69 | date = Dec 1997 | pmid = 9382871 | pmc = 2140202 | doi = 10.1083/jcb.139.5.1255 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SVIL supervillin| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6840}}</ref>

== Function ==

This gene encodes a bipartite protein with distinct [amino-](/source/Amino-terminal) and [carboxy-terminal](/source/carboxy-terminal) domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the [gelsolin family](/source/Gelsolin) of actin-binding proteins, which cap, nucleate, and/or sever actin filaments.<ref>{{cite journal | vauthors = Ghoshdastider U, Popp D, Burtnick LD, Robinson RC | title = The expanding superfamily of gelsolin homology domain proteins | journal = Cytoskeleton | volume = 70 | issue = 11 | pages = 775–95 | date = Nov 2013 | pmid = 24155256 | doi = 10.1002/cm.21149 | s2cid = 205643538 }}</ref> The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other [cytoskeletal proteins](/source/cytoskeletal_proteins) into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.<ref name="entrez" />

== Interactions ==

SVIL has been shown to [interact](/source/Protein-protein_interaction) with [Androgen receptor](/source/Androgen_receptor).<ref name=pmid11792840>{{cite journal | vauthors = Ting HJ, Yeh S, Nishimura K, Chang C | title = Supervillin associates with androgen receptor and modulates its transcriptional activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 2 | pages = 661–6 | date = Jan 2002 | pmid = 11792840 | pmc = 117362 | doi = 10.1073/pnas.022469899 | bibcode = 2002PNAS...99..661T | doi-access = free }}</ref>

== References ==
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== Further reading ==
{{refbegin|2}}
* {{cite journal|vauthors=Pope RK, Pestonjamasp KN, Smith KP, Wulfkuhle JD, Strassel CP, Lawrence JB, Luna EJ|title=Cloning, characterization, and chromosomal localization of human supervillin (SVIL)|journal=Genomics|volume=52|issue=3|pages=342–51|date=Sep 1998|pmid=9867483|doi=10.1006/geno.1998.5466}}
* {{cite journal|vauthors=Wulfkuhle JD, Donina IE, Stark NH, Pope RK, Pestonjamasp KN, Niswonger ML, Luna EJ|title=Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals|journal=Journal of Cell Science|volume=112 ( Pt 13)|issue=13|pages=2125–36|date=Jul 1999|doi=10.1242/jcs.112.13.2125|pmid=10362542|url=https://escholarship.umassmed.edu/wfc_pp/300}}
* {{cite journal|vauthors=Kim M, Jiang LH, Wilson HL, North RA, Surprenant A|title=Proteomic and functional evidence for a P2X7 receptor signalling complex|journal=The EMBO Journal|volume=20|issue=22|pages=6347–58|date=Nov 2001|pmid=11707406|pmc=125721|doi=10.1093/emboj/20.22.6347}}
* {{cite journal|vauthors=Ting HJ, Yeh S, Nishimura K, Chang C|title=Supervillin associates with androgen receptor and modulates its transcriptional activity|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=99|issue=2|pages=661–6|date=Jan 2002|pmid=11792840|pmc=117362|doi=10.1073/pnas.022469899|bibcode=2002PNAS...99..661T|doi-access=free}}
* {{cite journal|vauthors=Oh SW, Pope RK, Smith KP, Crowley JL, Nebl T, Lawrence JB, Luna EJ|title=Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton|journal=Journal of Cell Science|volume=116|issue=Pt 11|pages=2261–75|date=Jun 2003|pmid=12711699|doi=10.1242/jcs.00422|doi-access=free|hdl=2022/26449|hdl-access=free}}
* {{cite journal|vauthors=Chen Y, Takizawa N, Crowley JL, Oh SW, Gatto CL, Kambara T, Sato O, Li XD, Ikebe M, Luna EJ|title=F-actin and myosin II binding domains in supervillin|journal=The Journal of Biological Chemistry|volume=278|issue=46|pages=46094–106|date=Nov 2003|pmid=12917436|doi=10.1074/jbc.M305311200|doi-access=free}}
* {{cite journal|vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP|title=Large-scale characterization of HeLa cell nuclear phosphoproteins|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=101|issue=33|pages=12130–5|date=Aug 2004|pmid=15302935|pmc=514446|doi=10.1073/pnas.0404720101|bibcode=2004PNAS..10112130B|doi-access=free}}
* {{cite journal|vauthors=Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T|title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization|journal=Current Biology|volume=14|issue=16|pages=1436–50|date=Aug 2004|pmid=15324660|doi=10.1016/j.cub.2004.07.051|s2cid=2371325|doi-access=free}}
* {{cite journal|vauthors=Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M|title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks|journal=Cell|volume=127|issue=3|pages=635–48|date=Nov 2006|pmid=17081983|doi=10.1016/j.cell.2006.09.026|s2cid=7827573|doi-access=free}}
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Adapted from the Wikipedia article [SVIL](https://en.wikipedia.org/wiki/SVIL) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SVIL?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.