# STAB2

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Stabilin-2''' is a [protein](/source/protein) that in humans is encoded by the ''STAB2'' [gene](/source/gene).<ref name="pmid11829752">{{cite journal | vauthors = Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S | title = Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues | journal = The Biochemical Journal | volume = 362 | issue = Pt 1 | pages = 155–64 | date = February 2002 | pmid = 11829752 | pmc = 1222372 | doi = 10.1042/0264-6021:3620155 }}</ref><ref name="pmid12077138">{{cite journal | vauthors = Adachi H, Tsujimoto M | title = FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 34264–70 | date = September 2002 | pmid = 12077138 | doi = 10.1074/jbc.M204277200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAB2 stabilin 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55576}}</ref>

== Function ==

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 [fasciclin](/source/fasciclin_domain), 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like [hyaluronan](/source/hyaluronan)-binding Link module. The protein is primarily expressed on [liver sinusoidal endothelial cell](/source/liver_sinusoidal_endothelial_cell)s, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.<ref name="entrez" />

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S | title = FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products | journal = The Journal of Biological Chemistry | volume = 278 | issue = 15 | pages = 12613–7 | date = April 2003 | pmid = 12473645 | doi = 10.1074/jbc.M210211200 | doi-access = free }}
* {{cite journal | vauthors = Zhou B, McGary CT, Weigel JA, Saxena A, Weigel PH | title = Purification and molecular identification of the human hyaluronan receptor for endocytosis | journal = Glycobiology | volume = 13 | issue = 5 | pages = 339–49 | date = May 2003 | pmid = 12626425 | doi = 10.1093/glycob/cwg029 | doi-access = free }}
* {{cite journal | vauthors = Smedsrød B, Johansson S, Goerdt S | title = Shooting HARE | journal = Glycobiology | volume = 13 | issue = 5 | pages = 11G–12G; author reply 12G | date = May 2003 | pmid = 12751488 | doi = 10.1093/glycob/cwg072 | doi-access = free }}
* {{cite journal | vauthors = Dobreva G, Dambacher J, Grosschedl R | title = SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression | journal = Genes & Development | volume = 17 | issue = 24 | pages = 3048–61 | date = December 2003 | pmid = 14701874 | pmc = 305257 | doi = 10.1101/gad.1153003 }}
* {{cite journal | vauthors = Harris EN, Weigel JA, Weigel PH | title = Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE) | journal = The Journal of Biological Chemistry | volume = 279 | issue = 35 | pages = 36201–9 | date = August 2004 | pmid = 15208308 | doi = 10.1074/jbc.M405322200 | url = http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1054&context=biochemfacpub | doi-access = free }}
* {{cite journal | vauthors = Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P | title = Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding | journal = Experimental Cell Research | volume = 303 | issue = 1 | pages = 160–73 | date = February 2005 | pmid = 15572036 | doi = 10.1016/j.yexcr.2004.09.017 }}
* {{cite journal | vauthors = Harris EN, Kyosseva SV, Weigel JA, Weigel PH | title = Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE) | journal = The Journal of Biological Chemistry | volume = 282 | issue = 5 | pages = 2785–97 | date = February 2007 | pmid = 17145755 | doi = 10.1074/jbc.M607787200 | doi-access = free }}
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Adapted from the Wikipedia article [STAB2](https://en.wikipedia.org/wiki/STAB2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/STAB2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.