# ST8SIA6

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> Source: https://en.wikipedia.org/wiki/ST8SIA6
> Source revision: 1341236931
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}

'''ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6''' is a [protein](/source/protein) that in humans is encoded by the ST8SIA6 [gene](/source/gene).
<ref name="entrez">
{{cite web
| title = Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
| url = https://www.ncbi.nlm.nih.gov/gene/338596
| access-date = 2017-02-02
}}</ref>

==Function==

[Sialic acid](/source/Sialic_acid) is a key determinate of [oligosaccharide](/source/oligosaccharide) structures involved in cell-cell communication, cell-substrate interaction, [adhesion](/source/Cell_adhesion), and [protein targeting](/source/protein_targeting). ST8SIA6 belongs to a family of [sialyltransferases](/source/Sialyltransferase) (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

== References ==

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== Further reading ==

{{refbegin | 2}}
*{{cite journal |vauthors=Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR |title=Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression |journal=J. Leukoc. Biol. |volume=80 |issue=4 |pages=787–96 |year=2006 |pmid=16857734 |doi=10.1189/jlb.1005559 |s2cid=7578193 |doi-access= }}
*{{cite journal   |vauthors=Szabo R, Skropeta D, etal |title=Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities. |journal=Med. Res. Rev. |volume=37 |pages= 210–270 |year= 2017 |issue=2 |doi= 10.1002/med.21407 |pmid=27678392|s2cid=26280291 |url=https://ro.uow.edu.au/smhpapers/4202 |url-access=subscription }}
{{refend}}

{{NLM content}}

{{gene-10-stub}}

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Adapted from the Wikipedia article [ST8SIA6](https://en.wikipedia.org/wiki/ST8SIA6) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ST8SIA6?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.