# SSX1

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> Source: https://en.wikipedia.org/wiki/SSX1
> Source revision: 1301028747
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Protein SSX1''' is a [protein](/source/protein) that in humans is encoded by the ''SSX1'' [gene](/source/gene).<ref name="pmid7655467">{{cite journal | vauthors = de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A | title = Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas | journal = Hum Mol Genet | volume = 4 | issue = 6 | pages = 1097–9 |date=Oct 1995 | pmid = 7655467 | doi =10.1093/hmg/4.6.1097  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6756}}</ref>

The product of this gene belongs to the family of highly homologous [synovial sarcoma, X (SSX) breakpoint](/source/Synovial_sarcoma%2C_X_breakpoint) proteins. These proteins may function as transcriptional [repressor](/source/repressor)s. They are also capable of eliciting spontaneously [humoral](/source/humoral_immunity) and [cellular immune responses](/source/cell-mediated_immunity) in cancer patients, and are potentially useful targets in [cancer vaccine-based immunotherapy](/source/cancer_vaccine). SSX1, [SSX2](/source/SSX2) and [SSX4](/source/SSX4_(gene)) genes have been involved in the t(X;18) [chromosomal translocation](/source/chromosomal_translocation) characteristically found in all [synovial sarcoma](/source/synovial_sarcoma)s. This translocation results in the fusion of the synovial sarcoma translocation gene on [chromosome 18](/source/chromosome_18) to one of the SSX genes on [chromosome X](/source/chromosome_X). The encoded hybrid proteins are probably responsible for transforming activity.<ref name="entrez" />

==References==
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==Further reading==
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*{{cite journal   |vauthors=Crew AJ, Clark J, Fisher C, etal |title=Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma |journal=EMBO J. |volume=14 |issue= 10 |pages= 2333–40 |year= 1995 |doi=10.1002/j.1460-2075.1995.tb07228.x |pmid= 7539744 | pmc=398342  }}
*{{cite journal   |vauthors=Clark J, Rocques PJ, Crew AJ, etal |title=Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 502–8 |year= 1994 |pmid= 7951320 |doi= 10.1038/ng0894-502 |s2cid=20503729 }}
*{{cite journal   |vauthors=Sinke RJ, de Leeuw B, Janssen HA, etal |title=Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints |journal=Hum. Genet. |volume=92 |issue= 3 |pages= 305–8 |year= 1993 |pmid= 8406438 |doi=10.1007/BF00244478  |s2cid=12442743 }}
*{{cite journal  | vauthors=Chand A, Clark J, Cooper CS, Craig IW |title=Long-range organization of reiterated sequences, including the SSX1 cDNA at the OATL1 cluster in Xp11.23 |journal=Genomics |volume=30 |issue= 3 |pages= 545–52 |year= 1997 |pmid= 8825641 |doi= 10.1006/geno.1995.1275 }}
*{{cite journal   |vauthors=Thaete C, Brett D, Monaghan P, etal |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585–91 |year= 1999 |pmid= 10072425 |doi=10.1093/hmg/8.4.585  |doi-access= }}
*{{cite journal   |vauthors=Kato H, Tjernberg A, Zhang W, etal |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 |doi-access= free |hdl= 2066/170683 |hdl-access= free }}
*{{cite journal   |vauthors=de Bruijn DR, dos Santos NR, Kater-Baats E, etal |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285–98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073 |s2cid=11734893 }}
*{{cite journal   |vauthors=Yang K, Lui WO, Xie Y, etal |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas |journal=Oncogene |volume=21 |issue= 26 |pages= 4181–90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 |doi-access=  |s2cid=33515965 }}
*{{cite journal  | vauthors=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448–53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634 |s2cid=21174312 |doi-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Storlazzi CT, Mertens F, Mandahl N, etal |title=A novel fusion gene, SS18L1/SSX1, in synovial sarcoma |journal=Genes Chromosomes Cancer |volume=37 |issue= 2 |pages= 195–200 |year= 2003 |pmid= 12696068 |doi= 10.1002/gcc.10210 |s2cid=40041616 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | vauthors=Tvrdík D, Povýsil C, Svatosová J, Dundr P |title=Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue |journal=Med. Sci. Monit. |volume=11 |issue= 3 |pages= MT1–7 |year= 2005 |pmid= 15735574 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286 |bibcode=2005Natur.434..325R }}
*{{cite journal   |vauthors=Fernebro J, Francis P, Edén P, etal |title=Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1165–72 |year= 2006 |pmid= 16152617 |doi= 10.1002/ijc.21475 |doi-access= free }}
*{{cite journal   |vauthors=Sun Y, Gao D, Liu Y, etal |title=IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1 |journal=Oncogene |volume=25 |issue= 7 |pages= 1042–52 |year= 2006 |pmid= 16247461 |doi= 10.1038/sj.onc.1209143 |doi-access= free }}
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Adapted from the Wikipedia article [SSX1](https://en.wikipedia.org/wiki/SSX1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SSX1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.