# SSH3

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Protein-coding gene in the species Homo sapiens

SSH3 Identifiers Aliases SSH3, SSH3L, slingshot protein phosphatase 3 External IDs OMIM: 606780; MGI: 2683546; HomoloGene: 32372; GeneCards: SSH3; OMA:SSH3 - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,303,478 bp[1] End 67,312,607 bp[1] Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,311,696 bp[2] End 4,319,208 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right hemisphere of cerebellum minor salivary glands right uterine tube mucosa of transverse colon vagina skin of leg ectocervix skin of abdomen gastric mucosa Top expressed in granulocyte lip esophagus primary visual cortex superior frontal gyrus cerebellar cortex stomach colon neural layer of retina duodenum More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity actin binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytoskeleton nucleus Biological process regulation of lamellipodium assembly regulation of axonogenesis regulation of actin polymerization or depolymerization protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation cell morphogenesis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 54961 245857 Ensembl ENSG00000172830 ENSMUSG00000034616 UniProt Q8TE77 Q8K330 RefSeq (mRNA) NM_017857 NM_018276 NM_198113 NM_001356620 NM_001374687 RefSeq (protein) NP_060327 NP_932781 NP_001343549 Location (UCSC) Chr 11: 67.3 – 67.31 Mb Chr 19: 4.31 – 4.32 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Protein phosphatase Slingshot homolog 3** is an [enzyme](/source/Enzyme) that in humans is encoded by the *SSH3* [gene](/source/Gene).[5][6]

## Function

The [ADF (actin-depolymerizing factor)/cofilin family](/source/Cofilin) (see MIM 601442) is composed of stimulus-responsive mediators of [actin](/source/Actin) dynamics. ADF/cofilin [proteins](/source/Proteins) are inactivated by [kinases](/source/Kinases) such as LIM domain kinase-1 ([LIMK1](/source/LIMK1); MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000172830](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000172830) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000034616](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000034616) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=54961). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=245857). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11832213_5-0)** Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). ["Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin"](https://doi.org/10.1016%2FS0092-8674%2801%2900638-9). *Cell*. **108** (2): 233–46. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(01)00638-9](https://doi.org/10.1016%2FS0092-8674%2801%2900638-9). [PMID](/source/PMID_(identifier)) [11832213](https://pubmed.ncbi.nlm.nih.gov/11832213). [S2CID](/source/S2CID_(identifier)) [5576208](https://api.semanticscholar.org/CorpusID:5576208).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54961).

## Further reading

- Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). ["The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754063). *The Journal of Biological Chemistry*. **282** (44): 32520–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.M707041200](https://doi.org/10.1074%2Fjbc.M707041200). [PMC](/source/PMC_(identifier)) [2754063](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754063). [PMID](/source/PMID_(identifier)) [17848544](https://pubmed.ncbi.nlm.nih.gov/17848544).

- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nature Biotechnology*. **24** (10): 1285–92. [doi](/source/Doi_(identifier)):[10.1038/nbt1240](https://doi.org/10.1038%2Fnbt1240). [PMID](/source/PMID_(identifier)) [16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID](/source/S2CID_(identifier)) [14294292](https://api.semanticscholar.org/CorpusID:14294292).

- Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). ["Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548651). *The EMBO Journal*. **24** (3): 473–86. [doi](/source/Doi_(identifier)):[10.1038/sj.emboj.7600543](https://doi.org/10.1038%2Fsj.emboj.7600543). [PMC](/source/PMC_(identifier)) [548651](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548651). [PMID](/source/PMID_(identifier)) [15660133](https://pubmed.ncbi.nlm.nih.gov/15660133).

- Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". *Genes to Cells*. **8** (10): 811–24. [doi](/source/Doi_(identifier)):[10.1046/j.1365-2443.2003.00678.x](https://doi.org/10.1046%2Fj.1365-2443.2003.00678.x). [PMID](/source/PMID_(identifier)) [14531860](https://pubmed.ncbi.nlm.nih.gov/14531860). [S2CID](/source/S2CID_(identifier)) [24247372](https://api.semanticscholar.org/CorpusID:24247372).

v t e Esterase: protein tyrosine phosphatases (EC 3.1.3.48) Class I Classical PTPs Receptor type PTPs PTPRA PTPRB PTPRC PTPRD PTPRE PTPRF PTPRG PTPRH PTPRJ PTPRK PTPRM PTPRN PTPRN2 PTPRO PTPRQ PTPRR PTPRS PTPRT PTPRU PTPRZ1 PTPRZ2 Non receptor type PTPs PTPN1 PTPN2 PTPN3 PTPN4 PTPN5 PTPN6 PTPN7 PTPN9 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN20 PTPN21 PTPN22 PTPN23 VH1-like or dual specific phosphatases (DSPs) MAPK phosphatases (MKPs) DUSP1 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 DUSP10 DUSP16 MK-STYX Slingshots SSH1 SSH2 SSH3 PRLs PTP4A1 PTP4A2 PTP4A3 CDC14s CDC14A CDC14B CDKN3 PTP9Q22 Atypical DSPs DUSP3 DUSP11 DUSP12 DUSP13A DUSP13B DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP22 DUSP23 DUSP24 DUSP25 DUSP26 DUSP27 EMP2A RNGTT STYX Phosphatase and tensin homologs (PTENs) PTEN TPIP TPTE TNS TENC1 Myotubularins MTM1 MTMR2 MTMR3 MTMR4 MTMR5 MTMR6 MTMR7 MTMR8 MTMR9 MTMR10 MTMR11 MTMR12 MTMR13 MTMR14 MTMR15 Class II ACP1 Class III Cdc25 CDC25A CDC25B CDC25C Class IV EYA1 EYA2 EYA3 EYA4

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Adapted from the Wikipedia article [SSH3](https://en.wikipedia.org/wiki/SSH3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SSH3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.