# SRARP
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Steroid Receptor Associated and Regulated Protein (SRARP)''' in humans is a [protein](/source/protein) encoded by a [gene](/source/gene) of the same name with two [exon](/source/exon)s that is located on [chromosome 1p36.13](/source/Chromosome_1).[{{cite web |title=SRARP |url=https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28339 |website=HUGO Gene Nomenclature Committee |access-date=2 May 2020}}][{{cite web |title=SRARP steroid receptor associated and regulated protein [ Homo sapiens (human) ] |url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=149563 |website=NCBI |access-date=2 May 2020}}] SRARP contains 169 [amino acid](/source/amino_acid)s and has a [molecular weight](/source/molecular_weight) of 17,657 [Da](/source/Dalton_(unit)).[{{cite web |title=Steroid receptor-associated and regulated protein |url=https://www.uniprot.org/uniprot/Q8NEQ6#sequences |website=UniProt |access-date=2 May 2020}}]
== Expression and function in breast cancer ==
SRARP is co-expressed with the [estrogen receptor](/source/estrogen_receptor) (ER) and [androgen receptor](/source/androgen_receptor) (AR) in [breast cancer](/source/breast_cancer).[{{cite journal | vauthors = Su D, Fu X, Fan S, Wu X, Wang XX, Fu L, Dong XY, Ni JJ, Fu L, Zhu Z, Dong JT | display-authors = 6 | title = Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells | journal = The American Journal of Pathology | volume = 180 | issue = 3 | pages = 1189–1201 | date = March 2012 | pmid = 22341523 | pmc = 3349889 | doi = 10.1016/j.ajpath.2011.11.025 }}][{{cite journal | vauthors = Naderi A | title = C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer | journal = Oncotarget | volume = 8 | issue = 34 | pages = 57907–57933 | date = August 2017 | pmid = 28915724 | pmc = 5593696 | doi = 10.18632/oncotarget.17826 }}] In the [ER-positive breast cancer](/source/Hormone_receptor-positive_breast_cancer) cells, SRARP is involved in the transcriptional activities of ER and has shown an interaction with ER using the transient transfection of cells with SRARP and ER constructs.[{{cite journal | vauthors = Luo A, Su D, Zhang X, Qi L, Fu L, Dong JT | title = Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells | journal = Journal of Genetics and Genomics = Yi Chuan Xue Bao | volume = 43 | issue = 9 | pages = 565–567 | date = September 2016 | pmid = 27599921 | doi = 10.1016/j.jgg.2016.06.003 }}][{{cite journal | vauthors = Luo A, Zhang X | title = ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells | journal = Biochemical and Biophysical Research Communications | volume = 474 | issue = 2 | pages = 400–405 | date = May 2016 | pmid = 27125460 | doi = 10.1016/j.bbrc.2016.04.132 }}] In addition, in AR+ breast cancer cells, SRARP interacts with the endogenous AR protein and acts as a transcriptional [corepressor](/source/corepressor) of AR.[{{cite web | title = Symbol report for HSPB7 | url = https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/5249 | work = HUGO Gene Nomenclature Committee (HGNC) }}] are gene pairs that are positioned 5 kb apart on chromosome 1p36.13.[{{cite journal | vauthors = Naderi A | title = SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies | journal = Molecular Oncology | volume = 12 | issue = 5 | pages = 724–755 | date = May 2018 | pmid = 29577611 | pmc = 5928383 | doi = 10.1002/1878-0261.12195 }}] It is notable that the loss of chromosome 1p36.1 is common in malignancies, occurring in 34% of tumors[{{cite journal | vauthors = Henrich KO, Schwab M, Westermann F | title = 1p36 tumor suppression--a matter of dosage? | journal = Cancer Research | volume = 72 | issue = 23 | pages = 6079–88 | date = December 2012 | pmid = 23172308 | doi = 10.1158/0008-5472.CAN-12-2230 | doi-access = free }}][{{cite journal | vauthors = Knuutila S, Aalto Y, Autio K, Björkqvist AM, El-Rifai W, Hemmer S, Huhta T, Kettunen E, Kiuru-Kuhlefelt S, Larramendy ML, Lushnikova T, Monni O, Pere H, Tapper J, Tarkkanen M, Varis A, Wasenius VM, Wolf M, Zhu Y | display-authors = 6 | title = DNA copy number losses in human neoplasms | journal = The American Journal of Pathology | volume = 155 | issue = 3 | pages = 683–94 | date = September 1999 | pmid = 10487825 | pmc = 1866903 | doi = 10.1016/S0002-9440(10)65166-8 }}] SRARP and HSPB7 are broadly inactivated in malignancies by epigenetic silencing, copy-number loss, and less frequently by somatic mutations.