# SR1 RNA

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/SR1_RNA
> Markdown URL: https://mediated.wiki/source/SR1_RNA.md
> Source: https://en.wikipedia.org/wiki/SR1_RNA
> Source revision: 1209550263
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

In molecular biology, the **SR1 RNA** is a [small RNA](/source/Bacterial_small_RNA) (sRNA) produced by species of *[Bacillus](/source/Bacillus)* and closely related [bacteria](/source/Bacteria).[1] It is a dual-function [RNA](/source/RNA) which acts both as a [protein](/source/Protein)-coding RNA and as a regulatory sRNA.

SR1 RNA is involved in the regulation of [arginine](/source/Arginine) [catabolism](/source/Catabolism). SR1 RNA binds to [complementary](/source/Base_pair) stretches of ahrC [mRNA](/source/MRNA) (also known as argR and inhibits [translation](/source/Translation_(genetics)).[2][3] AhrC endodes an [arginine repressor](/source/Arginine_repressor_ArgR) protein which represses synthesis of arginine [biosynthetic](/source/Biosynthetic) [enzymes](/source/Enzymes) and activates arginine [catabolic](/source/Catabolic) enzymes via regulation of the rocABC and rocDEF [operons](/source/Operons).[4][5][6]

In addition to acting as a sRNA, SR1 also encodes a small peptide, SR1P. SR1P binds to [glyceraldehyde-3-phosphate dehydrogenase](/source/Glyceraldehyde-3-phosphate_dehydrogenase) (GapA) and stabilises the gapA operon mRNAs.[7]

SR1 expression is regulated by CcpA and CcpN.[8][9]

## See also

- [Bacterial small RNA](/source/Bacterial_small_RNA)

## References

1. **[^](#cite_ref-1)** Gimpel M, Preis H, Barth E, Gramzow L, Brantl S (October 13, 2012). ["SR1—a small RNA with two remarkably conserved functions"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526287). *Nucleic Acids Research*. **40** (22): 11659–11672. [doi](/source/Doi_(identifier)):[10.1093/nar/gks895](https://doi.org/10.1093%2Fnar%2Fgks895). [PMC](/source/PMC_(identifier)) [3526287](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526287). [PMID](/source/PMID_(identifier)) [23034808](https://pubmed.ncbi.nlm.nih.gov/23034808).

1. **[^](#cite_ref-2)** Heidrich N, Moll I, Brantl S (2007). ["In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935000). *Nucleic Acids Research*. **35** (13): 4331–4346. [doi](/source/Doi_(identifier)):[10.1093/nar/gkm439](https://doi.org/10.1093%2Fnar%2Fgkm439). [PMC](/source/PMC_(identifier)) [1935000](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935000). [PMID](/source/PMID_(identifier)) [17576690](https://pubmed.ncbi.nlm.nih.gov/17576690).

1. **[^](#cite_ref-3)** Heidrich N, Chinali A, Gerth U, Brantl S (October 2006). ["The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism"](https://doi.org/10.1111%2Fj.1365-2958.2006.05384.x). *Molecular Microbiology*. **62** (2): 520–536. [doi](/source/Doi_(identifier)):[10.1111/j.1365-2958.2006.05384.x](https://doi.org/10.1111%2Fj.1365-2958.2006.05384.x). [PMID](/source/PMID_(identifier)) [17020585](https://pubmed.ncbi.nlm.nih.gov/17020585).

1. **[^](#cite_ref-4)** North AK, Smith MC, Baumberg S (August 1, 1989). "Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor". *Gene*. **80** (1): 29–38. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(89)90247-3](https://doi.org/10.1016%2F0378-1119%2889%2990247-3). [PMID](/source/PMID_(identifier)) [2507400](https://pubmed.ncbi.nlm.nih.gov/2507400).

1. **[^](#cite_ref-5)** Czaplewski LG, North AK, Smith MC, Baumberg S, Stockley PG (January 1992). "Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis". *Mol. Microbiol*. **6** (2): 267–275. [doi](/source/Doi_(identifier)):[10.1111/j.1365-2958.1992.tb02008.x](https://doi.org/10.1111%2Fj.1365-2958.1992.tb02008.x). [PMID](/source/PMID_(identifier)) [1312212](https://pubmed.ncbi.nlm.nih.gov/1312212). [S2CID](/source/S2CID_(identifier)) [3219261](https://api.semanticscholar.org/CorpusID:3219261).

1. **[^](#cite_ref-6)** Dennis CA, Glykos NM, Parsons MR, Phillips SE (March 2002). "The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis". *Acta Crystallographica Section D*. **58** (Pt 3): 421–430. [doi](/source/Doi_(identifier)):[10.1107/s0907444901021692](https://doi.org/10.1107%2Fs0907444901021692). [PMID](/source/PMID_(identifier)) [11856827](https://pubmed.ncbi.nlm.nih.gov/11856827).

1. **[^](#cite_ref-7)** Gimpel M, Heidrich N, Mäder U, Krügel H, Brantl S (May 2010). ["A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon"](https://hal.archives-ouvertes.fr/hal-00552633/file/PEER_stage2_10.1111%252Fj.1365-2958.2010.07158.x.pdf) (PDF). *Molecular Microbiology*. **76** (4): 990–1009. [doi](/source/Doi_(identifier)):[10.1111/j.1365-2958.2010.07158.x](https://doi.org/10.1111%2Fj.1365-2958.2010.07158.x). [PMID](/source/PMID_(identifier)) [20444087](https://pubmed.ncbi.nlm.nih.gov/20444087).

1. **[^](#cite_ref-8)** Licht A, Preis S, Brantl S (October 2005). "Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis". *Molecular Microbiology*. **58** (1): 189–206. [doi](/source/Doi_(identifier)):[10.1111/j.1365-2958.2005.04810.x](https://doi.org/10.1111%2Fj.1365-2958.2005.04810.x). [PMID](/source/PMID_(identifier)) [16164558](https://pubmed.ncbi.nlm.nih.gov/16164558). [S2CID](/source/S2CID_(identifier)) [29961832](https://api.semanticscholar.org/CorpusID:29961832).

1. **[^](#cite_ref-9)** Licht A, Brantl S (October 2009). ["The transcriptional repressor CcpN from Bacillus subtilis uses different repression mechanisms at different promoters"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781557). *Journal of Biological Chemistry*. **284** (44): 30032–30038. [doi](/source/Doi_(identifier)):[10.1074/jbc.M109.033076](https://doi.org/10.1074%2Fjbc.M109.033076). [PMC](/source/PMC_(identifier)) [2781557](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781557). [PMID](/source/PMID_(identifier)) [19726675](https://pubmed.ncbi.nlm.nih.gov/19726675).

This molecular biology article is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Molecular-biology-stub)
- [t](/source/Template_talk%3AMolecular-biology-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Molecular-biology-stub)

---
Adapted from the Wikipedia article [SR1 RNA](https://en.wikipedia.org/wiki/SR1_RNA) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SR1_RNA?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.