# SPhos

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**SPhos** is a [phosphine ligand](/source/Phosphine_ligand) derived from [biphenyl](/source/Biphenyl). Its palladium complexes exhibit high activity for [Suzuki coupling](/source/Suzuki_reaction) reactions involving aryl chlorides, which are unreactive with palladium complexes of most other phosphine [ligands](/source/Ligand).[1] The ligand has convenient handling characteristics since it is air-stable.[2]

## See also

- [XPhos](/source/XPhos)
- [CPhos](/source/CPhos)
- [Suzuki reaction](/source/Suzuki_reaction)

## References

1. Barder, T.E.; Walker, S.D.; Martinelli, J.R.; Buchwald, S. L. (2005). "New Catalysts for Suzuki-Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure". *[J. Am. Chem. Soc.](/source/J._Am._Chem._Soc.)*. **127** (13): 4685–4696. [doi:10.1021/ja042491j](https://doi.org/10.1021/ja042491j). [PMID 15796535](https://pubmed.ncbi.nlm.nih.gov/15796535)

1. Altman, R.A. & Buchwald, S.L. (2007). "Pd-Catalyzed Suzuki-Miyaura Reactions of Aryl Halides Using Bulky Biarylmonophosphine Ligands". *[Nature Protocols](/source/Nature_Protocols)*. **2** (12): 3115–3121. [doi:10.1038/nprot.2007.411](https://doi.org/10.1038/nprot.2007.411). [PMID 18079711](https://pubmed.ncbi.nlm.nih.gov/18079711). [S2CID 11069335](https://api.semanticscholar.org/CorpusID:11069335)

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