# SPIB

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Protein that controls transcription of a set of genes in eukaryotes

SPIB Identifiers Aliases SPIB, SPI-B, Spi-B transcription factor External IDs OMIM: 606802; MGI: 892986; HomoloGene: 79220; GeneCards: SPIB; OMA:SPIB - orthologs Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,418,938 bp[1] End 50,431,314 bp[1] Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.83 cM Start 44,175,417 bp[2] End 44,181,495 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node mucosa of transverse colon appendix granulocyte buccal mucosa cell spleen rectum mucosa of ileum epithelium of nasopharynx blood Top expressed in mesenteric lymph nodes spleen tibiofemoral joint blood granulocyte subcutaneous adipose tissue submandibular gland bone marrow thymus femur More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription by RNA polymerase II cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 6689 272382 Ensembl ENSG00000269404 ENSMUSG00000008193 UniProt Q01892 O35906 RefSeq (mRNA) NM_003121 NM_001243998 NM_001243999 NM_001244000 NM_019866 RefSeq (protein) NP_001230927 NP_001230928 NP_001230929 NP_003112 NP_063919 Location (UCSC) Chr 19: 50.42 – 50.43 Mb Chr 7: 44.18 – 44.18 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Transcription factor Spi-B** is a [protein](/source/Protein) that in humans is encoded by the *SPIB* [gene](/source/Gene).[5][6]

## Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][6]

## Interactions

SPIB has been shown to [interact](/source/Protein-protein_interaction) with [MAPK3](/source/MAPK3)[7] and [MAPK8](/source/MAPK8).[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000269404](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269404) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000008193](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000008193) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6689). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=272382). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid1406622_5-0)** Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). ["Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC360353). *Molecular and Cellular Biology*. **12** (10): 4297–304. [doi](/source/Doi_(identifier)):[10.1128/mcb.12.10.4297](https://doi.org/10.1128%2Fmcb.12.10.4297). [PMC](/source/PMC_(identifier)) [360353](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC360353). [PMID](/source/PMID_(identifier)) [1406622](https://pubmed.ncbi.nlm.nih.gov/1406622).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6689).

1. ^ [***a***](#cite_ref-pmid8632909_7-0) [***b***](#cite_ref-pmid8632909_7-1) Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". *Oncogene*. **12** (4): 863–73. [PMID](/source/PMID_(identifier)) [8632909](https://pubmed.ncbi.nlm.nih.gov/8632909).

## Further reading

- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". *Oncogene*. **12** (4): 863–73. [PMID](/source/PMID_(identifier)) [8632909](https://pubmed.ncbi.nlm.nih.gov/8632909).

- Ray-Gallet D, Tavitian A, Moreau-Gachelin F (June 1996). "An alternatively spliced isoform of the Spi-B transcription factor". *Biochemical and Biophysical Research Communications*. **223** (2): 257–63. [Bibcode](/source/Bibcode_(identifier)):[1996BBRC..223..257R](https://ui.adsabs.harvard.edu/abs/1996BBRC..223..257R). [doi](/source/Doi_(identifier)):[10.1006/bbrc.1996.0881](https://doi.org/10.1006%2Fbbrc.1996.0881). [PMID](/source/PMID_(identifier)) [8670269](https://pubmed.ncbi.nlm.nih.gov/8670269).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Rao S, Matsumura A, Yoon J, Simon MC (April 1999). ["SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1"](https://doi.org/10.1074%2Fjbc.274.16.11115). *The Journal of Biological Chemistry*. **274** (16): 11115–24. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.16.11115](https://doi.org/10.1074%2Fjbc.274.16.11115). [PMID](/source/PMID_(identifier)) [10196196](https://pubmed.ncbi.nlm.nih.gov/10196196).

- Nagy M, Chapuis B, Matthes T (February 2002). ["Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells"](https://doi.org/10.1046%2Fj.1365-2141.2002.03271.x). *British Journal of Haematology*. **116** (2): 429–35. [doi](/source/Doi_(identifier)):[10.1046/j.1365-2141.2002.03271.x](https://doi.org/10.1046%2Fj.1365-2141.2002.03271.x). [PMID](/source/PMID_(identifier)) [11841448](https://pubmed.ncbi.nlm.nih.gov/11841448). [S2CID](/source/S2CID_(identifier)) [22132659](https://api.semanticscholar.org/CorpusID:22132659).

- Yamamoto H, Kihara-Negishi F, Yamada T, Suzuki M, Nakano T, Oikawa T (February 2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". *Cell Growth & Differentiation*. **13** (2): 69–75. [PMID](/source/PMID_(identifier)) [11864910](https://pubmed.ncbi.nlm.nih.gov/11864910).

- Schotte R, Rissoan MC, Bendriss-Vermare N, Bridon JM, Duhen T, Weijer K, Brière F, Spits H (February 2003). ["The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development"](https://doi.org/10.1182%2Fblood-2002-02-0438). *Blood*. **101** (3): 1015–23. [doi](/source/Doi_(identifier)):[10.1182/blood-2002-02-0438](https://doi.org/10.1182%2Fblood-2002-02-0438). [PMID](/source/PMID_(identifier)) [12393575](https://pubmed.ncbi.nlm.nih.gov/12393575).

- Schotte R, Nagasawa M, Weijer K, Spits H, Blom B (December 2004). ["The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development"](https://pure.uva.nl/ws/files/4029340/45204_205399y.pdf) (PDF). *The Journal of Experimental Medicine*. **200** (11): 1503–9. [doi](/source/Doi_(identifier)):[10.1084/jem.20041231](https://doi.org/10.1084%2Fjem.20041231). [PMC](/source/PMC_(identifier)) [2211952](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211952). [PMID](/source/PMID_(identifier)) [15583020](https://pubmed.ncbi.nlm.nih.gov/15583020).

- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, [Zoghbi HY](/source/Huda_Zoghbi), Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Geng CD, Vedeckis WV (December 2005). ["c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter"](https://doi.org/10.1074%2Fjbc.M508245200). *The Journal of Biological Chemistry*. **280** (52): 43264–71. [doi](/source/Doi_(identifier)):[10.1074/jbc.M508245200](https://doi.org/10.1074%2Fjbc.M508245200). [PMID](/source/PMID_(identifier)) [16263717](https://pubmed.ncbi.nlm.nih.gov/16263717).

- Dontje W, Schotte R, Cupedo T, Nagasawa M, Scheeren F, Gimeno R, Spits H, Blom B (March 2006). ["Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B"](https://doi.org/10.1182%2Fblood-2005-05-2090). *Blood*. **107** (6): 2446–52. [doi](/source/Doi_(identifier)):[10.1182/blood-2005-05-2090](https://doi.org/10.1182%2Fblood-2005-05-2090). [PMID](/source/PMID_(identifier)) [16317090](https://pubmed.ncbi.nlm.nih.gov/16317090).

## External links

- [SPIB+protein,+human](https://meshb.nlm.nih.gov/record/ui?name=SPIB+protein%2C+human) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

v t e Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B sMaf F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist Group B FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D DEC 1 2 BHLHA9 Pho4 ID 1 2 3 4 Group E HES 1 2 3 4 5 6 7 HEY 1 2 L Group F bHLH-COE EBF1 (1.3) bHLH-ZIP AP-4 MAX MXD1 MXD3 MITF MNT MLX MLXIPL MXI1 Myc SREBP 1 2 USF1 (1.4) NF-1 NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4) (1.5) RF-X RFX 1 2 3 4 5 6 ANK (1.6) Basic helix-span-helix (bHSH) AP-2 α β γ δ ε (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX subfamily 3 Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ subfamily 4 NUR NGFIB NOR1 NURR1 subfamily 5 LRH-1 SF1 subfamily 6 GCNF subfamily 0 DAX1 SHP (2.2) Other Cys4 GATA 1 2 3 4 5 6 MTA 1 2 3 TRPS1 (2.3) Cys2His2 General transcription factors TFIIA TFIIB TFIID TFIIE 1 2 TFIIF 1 2 TFIIH 1 2 4 2I 3A 3C1 3C2 ATBF1 BCL 6 11A 11B CTCF E4F1 EGR 1 2 3 4 ERV3 GFI1 GLI family 1 2 3 REST S1 S2 YY1 HIC 1 2 HIVEP 1 2 3 IKZF 1 2 3 ILF 2 3 Sp/KLF family KLF 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 SP 1 2 4 7 8 MTF1 MYT1 OSR1 PRDM9 SALL 1 2 3 4 TSHZ3 WT1 Zbtb7 7A 7B ZBTB 11 16 17 20 21 32 33 40 zinc finger 3 7 9 10 19 22 24 33B 34 35 41 43 44 51 74 143 146 148 165 202 217 219 238 239 259 267 268 281 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 804A (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE DIDO1 GRLF1 ING 1 2 4 JARID 1A 1B 1C 1D 2 JMJD1B (2.6) WRKY WRKY (3) Helix-turn-helix domains (3.1) Homeodomain Antennapedia ANTP class protoHOX Hox-like ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox: Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1 metaHOX NK-like BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF 1 3 6 8 10 16 17 20 21A POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 SATB2 ZEB 1 2 (3.2) Paired box PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 PROP1 PHOX 2A 2B RAX SHOX SHOX2 VSX1 VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5 D4L6 E1 E3 F1 F2 G1 H1 I1 I2 I3 J1 J2 J3 K1 K2 L1 L2 M1 N1 N2 N3 N4 O1 O3 O4 O6 P1 P2 P3 P4 Q1 R1 R2 S1 (3.4) Heat shock factors HSF 1 2 4 (3.5) Tryptophan clusters ELF 2 4 5 EHF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain transcriptional enhancer factor 1 2 3 4 (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5 (4.2) STAT STAT 1 2 3 4 5 6 (4.3) p53-like p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1 (0.3) Pocket domain Rb RBL1 RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 EREBP B3 (0.6) Miscellaneous ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma see also transcription factor/coregulator deficiencies

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Adapted from the Wikipedia article [SPIB](https://en.wikipedia.org/wiki/SPIB) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SPIB?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.