# SOX18

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Protein-coding gene in the species Homo sapiens

SOX18 Identifiers Aliases SOX18, HLTS, HLTRS, SRY-box 18, SRY-box transcription factor 18 External IDs OMIM: 601618; MGI: 103559; HomoloGene: 7546; GeneCards: SOX18; OMA:SOX18 - orthologs Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,047,582 bp[1] End 64,049,639 bp[1] Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.71 cM Start 181,311,629 bp[2] End 181,313,433 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung left uterine tube right auricle of heart right lobe of thyroid gland left ventricle right coronary artery gastric mucosa body of uterus left coronary artery Top expressed in interventricular septum glomerular capillary right lung endothelial cell of lymphatic vessel left lung right lung lobe external carotid artery left lung lobe lactiferous gland internal carotid artery More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process hair follicle development establishment of endothelial barrier hair cycle process regulation of transcription, DNA-templated stem cell fate specification lymphangiogenesis blood vessel endothelial cell migration lymphatic endothelial cell differentiation endocardium formation outflow tract morphogenesis mRNA transcription by RNA polymerase II in utero embryonic development negative regulation of transcription by RNA polymerase II cell maturation endocardial cell differentiation lymph vessel development transcription, DNA-templated embryonic heart tube development vasculogenesis positive regulation of transcription, DNA-templated heart looping development of the heart vasculature development blood vessel development angiogenesis negative regulation of transcription, DNA-templated regulation of stem cell proliferation positive regulation of transcription by RNA polymerase II cell differentiation Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 54345 20672 Ensembl ENSG00000203883 ENSMUSG00000046470 UniProt P35713 P43680 RefSeq (mRNA) NM_018419 NM_009236 RefSeq (protein) NP_060889 NP_033262 Location (UCSC) Chr 20: 64.05 – 64.05 Mb Chr 2: 181.31 – 181.31 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Transcription factor SOX-18** is a [protein](/source/Protein) that in humans is encoded by the *SOX18* [gene](/source/Gene).[5][6]

## Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of [hypotrichosis](/source/Hypotrichosis)-[lymphedema](/source/Lymphedema)-[telangiectasia](/source/Telangiectasia) (HLTS).[7][6] An autosomal truncating dominant mutation in this gene has also been associated with renal failure in the condition [hypotrichosis](/source/Hypotrichosis)-[lymphedema](/source/Lymphedema)-[telangiectasia](/source/Telangiectasia)-[renal](/source/Renal) defect syndrome (HLTRS).[8][9]

## Interactions

SOX18 has been shown to [interact](/source/Protein-protein_interaction) with:

[MEF2C](/source/MEF2C)[10]

[RBPJ](/source/RBPJ)[11]

## See also

- [SOX genes](/source/SOX_genes)

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000203883](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000203883) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000046470](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000046470) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=54345). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=20672). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid10807548_5-0)** Azuma T, Seki N, Yoshikawa T, Saito T, Masuho Y, Muramatsu M (July 2000). ["cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18"](https://doi.org/10.1007%2Fs100380050210). *Journal of Human Genetics*. **45** (3): 192–5. [doi](/source/Doi_(identifier)):[10.1007/s100380050210](https://doi.org/10.1007%2Fs100380050210). [PMID](/source/PMID_(identifier)) [10807548](https://pubmed.ncbi.nlm.nih.gov/10807548).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: SO X18 SRY (sex determining region Y)-box 18"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54345).

1. **[^](#cite_ref-7)** Valenzuela I, Fernández-Alvarez P, Plaja A, Ariceta G, Sabaté-Rotés A, García-Arumí E, Vendrell T, Tizzano E (May 2018). "Further delineation of the SOX18-related Hypotrichosis, Lymphedema, Telangiectasia syndrome (HTLS)". *European Journal of Medical Genetics*. **61** (5): 269–272. [doi](/source/Doi_(identifier)):[10.1016/j.ejmg.2018.01.001](https://doi.org/10.1016%2Fj.ejmg.2018.01.001). [PMID](/source/PMID_(identifier)) [29307792](https://pubmed.ncbi.nlm.nih.gov/29307792).

1. **[^](#cite_ref-8)** Moalem S, Brouillard P, Kuypers D, Legius E, Harvey E, Taylor G, Francois M, Vikkula M, Chitayat D (April 2015). "Hypotrichosis-lymphedema-telangiectasia-renal defect associated with a truncating mutation in the SOX18 gene". *Clinical Genetics*. **87** (4): 378–82. [doi](/source/Doi_(identifier)):[10.1111/cge.12388](https://doi.org/10.1111%2Fcge.12388). [PMID](/source/PMID_(identifier)) [24697860](https://pubmed.ncbi.nlm.nih.gov/24697860). [S2CID](/source/S2CID_(identifier)) [32417398](https://api.semanticscholar.org/CorpusID:32417398).

1. **[^](#cite_ref-9)** ["Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome"](https://disorders.eyes.arizona.edu/disorders/hypotrichosis-lymphedema-telangiectasia-renal-defect-syndrome). The University of Arizona Health Sciences.

1. **[^](#cite_ref-pmid11554755_10-0)** Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE (September 2001). "SOX18 directly interacts with MEF2C in endothelial cells". *Biochemical and Biophysical Research Communications*. **287** (2): 493–500. [Bibcode](/source/Bibcode_(identifier)):[2001BBRC..287..493H](https://ui.adsabs.harvard.edu/abs/2001BBRC..287..493H). [doi](/source/Doi_(identifier)):[10.1006/bbrc.2001.5589](https://doi.org/10.1006%2Fbbrc.2001.5589). [PMID](/source/PMID_(identifier)) [11554755](https://pubmed.ncbi.nlm.nih.gov/11554755).

1. **[^](#cite_ref-11)** Overman J, Fontaine F, Wylie-Sears J, Moustaqil M, Huang L, Meurer M, et al. (July 2019). ["R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667216). *eLife*. **8** e43026. [doi](/source/Doi_(identifier)):[10.7554/eLife.43026](https://doi.org/10.7554%2FeLife.43026). [PMC](/source/PMC_(identifier)) [6667216](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667216). [PMID](/source/PMID_(identifier)) [31358114](https://pubmed.ncbi.nlm.nih.gov/31358114).

## Further reading

- Wilson M, Koopman P (August 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". *Current Opinion in Genetics & Development*. **12** (4): 441–6. [doi](/source/Doi_(identifier)):[10.1016/S0959-437X(02)00323-4](https://doi.org/10.1016%2FS0959-437X%2802%2900323-4). [PMID](/source/PMID_(identifier)) [12100890](https://pubmed.ncbi.nlm.nih.gov/12100890).

- Schepers GE, Teasdale RD, Koopman P (August 2002). ["Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families"](https://doi.org/10.1016%2FS1534-5807%2802%2900223-X). *Developmental Cell*. **3** (2): 167–70. [doi](/source/Doi_(identifier)):[10.1016/S1534-5807(02)00223-X](https://doi.org/10.1016%2FS1534-5807%2802%2900223-X). [PMID](/source/PMID_(identifier)) [12194848](https://pubmed.ncbi.nlm.nih.gov/12194848).

- Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (June 1992). ["A conserved family of genes related to the testis determining gene, SRY"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC336939). *Nucleic Acids Research*. **20** (11): 2887. [doi](/source/Doi_(identifier)):[10.1093/nar/20.11.2887](https://doi.org/10.1093%2Fnar%2F20.11.2887). [PMC](/source/PMC_(identifier)) [336939](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC336939). [PMID](/source/PMID_(identifier)) [1614875](https://pubmed.ncbi.nlm.nih.gov/1614875).

- Dunn TL, Mynett-Johnson L, Wright EM, Hosking BM, Koopman PA, Muscat GE (August 1995). "Sequence and expression of Sox-18 encoding a new HMG-box transcription factor". *Gene*. **161** (2): 223–5. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(95)00280-J](https://doi.org/10.1016%2F0378-1119%2895%2900280-J). [PMID](/source/PMID_(identifier)) [7665083](https://pubmed.ncbi.nlm.nih.gov/7665083).

- Stanojcić S, Stevanović M (June 2000). "The human SOX18 gene: cDNA cloning and high resolution mapping". *Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression*. **1492** (1): 237–41. [doi](/source/Doi_(identifier)):[10.1016/s0167-4781(00)00078-6](https://doi.org/10.1016%2Fs0167-4781%2800%2900078-6). [PMID](/source/PMID_(identifier)) [10858556](https://pubmed.ncbi.nlm.nih.gov/10858556).

- Pennisi DJ, James KM, Hosking B, Muscat GE, Koopman P (December 2000). ["Structure, mapping, and expression of human SOX18"](https://github.com/JeremyMGibson/verbose-garbanzo/raw/master/107176/676549). *Mammalian Genome*. **11** (12): 1147–9. [doi](/source/Doi_(identifier)):[10.1007/s003350010216](https://doi.org/10.1007%2Fs003350010216). [PMID](/source/PMID_(identifier)) [11130989](https://pubmed.ncbi.nlm.nih.gov/11130989). [S2CID](/source/S2CID_(identifier)) [11826232](https://api.semanticscholar.org/CorpusID:11826232).

- Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE (September 2001). "SOX18 directly interacts with MEF2C in endothelial cells". *Biochemical and Biophysical Research Communications*. **287** (2): 493–500. [Bibcode](/source/Bibcode_(identifier)):[2001BBRC..287..493H](https://ui.adsabs.harvard.edu/abs/2001BBRC..287..493H). [doi](/source/Doi_(identifier)):[10.1006/bbrc.2001.5589](https://doi.org/10.1006%2Fbbrc.2001.5589). [PMID](/source/PMID_(identifier)) [11554755](https://pubmed.ncbi.nlm.nih.gov/11554755).

- Dintilhac A, Bernués J (March 2002). ["HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences"](https://doi.org/10.1074%2Fjbc.M108417200). *The Journal of Biological Chemistry*. **277** (9): 7021–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.M108417200](https://doi.org/10.1074%2Fjbc.M108417200). [hdl](/source/Hdl_(identifier)):[10261/112516](https://hdl.handle.net/10261%2F112516). [PMID](/source/PMID_(identifier)) [11748221](https://pubmed.ncbi.nlm.nih.gov/11748221).

- Saitoh T, Katoh M (September 2002). "Expression of human SOX18 in normal tissues and tumors". *International Journal of Molecular Medicine*. **10** (3): 339–44. [doi](/source/Doi_(identifier)):[10.3892/ijmm.10.3.339](https://doi.org/10.3892%2Fijmm.10.3.339). [PMID](/source/PMID_(identifier)) [12165811](https://pubmed.ncbi.nlm.nih.gov/12165811).

- Irrthum A, Devriendt K, Chitayat D, Matthijs G, Glade C, Steijlen PM, Fryns JP, Van Steensel MA, Vikkula M (June 2003). ["Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180307). *American Journal of Human Genetics*. **72** (6): 1470–8. [doi](/source/Doi_(identifier)):[10.1086/375614](https://doi.org/10.1086%2F375614). [PMC](/source/PMC_(identifier)) [1180307](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180307). [PMID](/source/PMID_(identifier)) [12740761](https://pubmed.ncbi.nlm.nih.gov/12740761).

- García-Ramírez M, Martínez-González J, Juan-Babot JO, Rodríguez C, Badimon L (November 2005). ["Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth"](https://doi.org/10.1161%2F01.ATV.0000187464.81959.23). *Arteriosclerosis, Thrombosis, and Vascular Biology*. **25** (11): 2398–403. [doi](/source/Doi_(identifier)):[10.1161/01.ATV.0000187464.81959.23](https://doi.org/10.1161%2F01.ATV.0000187464.81959.23). [PMID](/source/PMID_(identifier)) [16179596](https://pubmed.ncbi.nlm.nih.gov/16179596).

- Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR, Koopman P (August 2006). ["Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development"](https://doi.org/10.1093%2Fjnci%2Fdjj299). *Journal of the National Cancer Institute*. **98** (15): 1060–7. [doi](/source/Doi_(identifier)):[10.1093/jnci/djj299](https://doi.org/10.1093%2Fjnci%2Fdjj299). [PMID](/source/PMID_(identifier)) [16882943](https://pubmed.ncbi.nlm.nih.gov/16882943).

- Olbromski M, Podhorska-Okołów M, Dzięgiel P. (2018). ["Role of the SOX18 protein in neoplastic processes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036441). *Oncology Letters*. **16** (2): 1383–89. [doi](/source/Doi_(identifier)):[10.3892/ol.2018.8819](https://doi.org/10.3892%2Fol.2018.8819). [PMC](/source/PMC_(identifier)) [6036441](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036441). [PMID](/source/PMID_(identifier)) [30008814](https://pubmed.ncbi.nlm.nih.gov/30008814).{{[cite journal](https://en.wikipedia.org/wiki/Template:Cite_journal)}}: CS1 maint: multiple names: authors list ([link](https://en.wikipedia.org/wiki/Category:CS1_maint:_multiple_names:_authors_list))

## External links

- [SOX18+protein,+human](https://meshb.nlm.nih.gov/record/ui?name=SOX18+protein%2C+human) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

v t e Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B sMaf F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist Group B FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D DEC 1 2 BHLHA9 Pho4 ID 1 2 3 4 Group E HES 1 2 3 4 5 6 7 HEY 1 2 L Group F bHLH-COE EBF1 (1.3) bHLH-ZIP AP-4 MAX MXD1 MXD3 MITF MNT MLX MLXIPL MXI1 Myc SREBP 1 2 USF1 (1.4) NF-1 NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4) (1.5) RF-X RFX 1 2 3 4 5 6 ANK (1.6) Basic helix-span-helix (bHSH) AP-2 α β γ δ ε (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX subfamily 3 Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ subfamily 4 NUR NGFIB NOR1 NURR1 subfamily 5 LRH-1 SF1 subfamily 6 GCNF subfamily 0 DAX1 SHP (2.2) Other Cys4 GATA 1 2 3 4 5 6 MTA 1 2 3 TRPS1 (2.3) Cys2His2 General transcription factors TFIIA TFIIB TFIID TFIIE 1 2 TFIIF 1 2 TFIIH 1 2 4 2I 3A 3C1 3C2 ATBF1 BCL 6 11A 11B CTCF E4F1 EGR 1 2 3 4 ERV3 GFI1 GLI family 1 2 3 REST S1 S2 YY1 HIC 1 2 HIVEP 1 2 3 IKZF 1 2 3 ILF 2 3 Sp/KLF family KLF 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 SP 1 2 4 7 8 MTF1 MYT1 OSR1 PRDM9 SALL 1 2 3 4 TSHZ3 WT1 Zbtb7 7A 7B ZBTB 11 16 17 20 21 32 33 40 zinc finger 3 7 9 10 19 22 24 33B 34 35 41 43 44 51 74 143 146 148 165 202 217 219 238 239 259 267 268 281 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 804A (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE DIDO1 GRLF1 ING 1 2 4 JARID 1A 1B 1C 1D 2 JMJD1B (2.6) WRKY WRKY (3) Helix-turn-helix domains (3.1) Homeodomain Antennapedia ANTP class protoHOX Hox-like ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox: Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1 metaHOX NK-like BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF 1 3 6 8 10 16 17 20 21A POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 SATB2 ZEB 1 2 (3.2) Paired box PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 PROP1 PHOX 2A 2B RAX SHOX SHOX2 VSX1 VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5 D4L6 E1 E3 F1 F2 G1 H1 I1 I2 I3 J1 J2 J3 K1 K2 L1 L2 M1 N1 N2 N3 N4 O1 O3 O4 O6 P1 P2 P3 P4 Q1 R1 R2 S1 (3.4) Heat shock factors HSF 1 2 4 (3.5) Tryptophan clusters ELF 2 4 5 EHF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain transcriptional enhancer factor 1 2 3 4 (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5 (4.2) STAT STAT 1 2 3 4 5 6 (4.3) p53-like p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1 (0.3) Pocket domain Rb RBL1 RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 EREBP B3 (0.6) Miscellaneous ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma see also transcription factor/coregulator deficiencies

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Adapted from the Wikipedia article [SOX18](https://en.wikipedia.org/wiki/SOX18) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SOX18?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.