# SOSTDC1

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**Sclerostin domain-containing protein 1** is a [protein](/source/Protein) that in humans is encoded by the *SOSTDC1* [gene](/source/Gene).[1]

## Function

This gene is a member of the [sclerostin](/source/Sclerostin) family and encodes Uterine sensitization-associated gene-1 (USAG-1), an [N-glycosylated](/source/N-glycosylation), [secreted](/source/Secreted_protein) protein with a [C-terminal](/source/C-terminus), [cystine](/source/Cystine), knot-like domain. This protein functions as a [bone morphogenetic protein](/source/Bone_morphogenetic_protein) (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during [cellular proliferation](/source/Cellular_proliferation), [differentiation](/source/Cellular_differentiation), and [programmed cell death](/source/Programmed_cell_death).[1]

Inhibition of USAG-1 is of interest as a potential means of stimulating [tooth regeneration](/source/Tooth_regeneration) for dentistry.[2][3][4]

## References

1. ["Entrez Gene: SOSTDC1 sclerostin domain containing 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=25928)

1. Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". *Science Advances*. **7** (7). [doi:10.1126/sciadv.abf1798](https://doi.org/10.1126/sciadv.abf1798). [PMC 7880588](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880588). [PMID 33579703](https://pubmed.ncbi.nlm.nih.gov/33579703)

1. Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". *Regenerative Therapy*. **22**: 160–168. [doi:10.1016/j.reth.2023.01.004](https://doi.org/10.1016/j.reth.2023.01.004). [PMC 9931762](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931762). [PMID 36819612](https://pubmed.ncbi.nlm.nih.gov/36819612)

1. ["World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan."](https://mainichi.jp/english/articles/20230609/p2a/00m/0sc/026000c). *Mainichi*. 12 June 2023.

## Further reading

- Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". *Cytokine & Growth Factor Reviews*. **16** (3): 309–17. [doi:10.1016/j.cytogfr.2005.02.007](https://doi.org/10.1016/j.cytogfr.2005.02.007). [PMID 15951218](https://pubmed.ncbi.nlm.nih.gov/15951218)
- Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". *Developmental Biology*. **264** (1): 91–105. [doi:10.1016/j.ydbio.2003.08.011](https://doi.org/10.1016/j.ydbio.2003.08.011). [PMID 14623234](https://pubmed.ncbi.nlm.nih.gov/14623234)
- Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". *Biochemical and Biophysical Research Communications*. **316** (2): 490–500. [doi:10.1016/j.bbrc.2004.02.075](https://doi.org/10.1016/j.bbrc.2004.02.075). [PMID 15020244](https://pubmed.ncbi.nlm.nih.gov/15020244)
- Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". *The Journal of Biological Chemistry*. **279** (40): 42128–38. [doi:10.1074/jbc.M403190200](https://doi.org/10.1074/jbc.M403190200). [PMID 15280373](https://pubmed.ncbi.nlm.nih.gov/15280373)

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Adapted from the Wikipedia article [SOSTDC1](https://en.wikipedia.org/wiki/SOSTDC1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SOSTDC1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.