# SN 35210

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/SN_35210
> Markdown URL: https://mediated.wiki/source/SN_35210.md
> Source: https://en.wikipedia.org/wiki/SN_35210
> Source revision: 1329617020
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = <nowiki>Methyl 4-{[1-(2-chlorophenyl)-2-oxocyclohexyl]amino}pentanoate</nowiki>
| image = SN 35210.svg
| image_class = skin-invert-image
| width = 220

<!--Clinical data-->
| tradename =  
| legal_status = [Investigational new drug](/source/Investigational_new_drug)
| legal_CA = 
| legal_DE = 
| legal_UK =

<!--Identifiers-->
| CAS_number = 1450615-41-4
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = DS5KFJ4488
| ATC_prefix = none
| PubChem = 71769517
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID =

<!--Chemical data-->
| C=18 | H=24 | Cl=1 | N=1 | O=3
| StdInChI=1S/C18H24ClNO3/c1-23-17(22)11-5-7-13-20-18(12-6-4-10-16(18)21)14-8-2-3-9-15(14)19/h2-3,8-9,20H,4-7,10-13H2,1H3
| StdInChIKey = QFFBIIVCZDWTKZ-UHFFFAOYSA-N
| smiles = Clc1ccccc1C2(NCCCCC(=O)OC)CCCCC2=O
}}

'''SN 35210''' is an [arylcyclohexylamine](/source/arylcyclohexylamine) [dissociative](/source/Dissociative_drug) [anesthetic](/source/anesthesia) drug. It was derived from [ketamine](/source/ketamine) with the intention of producing a shorter acting agent more suitable to be used as a stand-alone drug, whereas ketamine itself generally has to be used in combination with other drugs such as [midazolam](/source/midazolam) to minimise the occurrence of [emergence reactions](/source/Emergence_delirium) due to its [hallucinogen](/source/hallucinogen)ic side effects. In common with other short-acting anaesthetic drugs such as [remifentanil](/source/remifentanil) and [remimazolam](/source/remimazolam), SN 35210 has had the [chemical structure](/source/chemical_structure) modified to incorporate a methyl [ester](/source/ester) group which is rapidly metabolised to a [carboxylic acid](/source/carboxylic_acid), producing an inactive compound and thus rapidly terminating the effects of the drug. It was selected for development from a series of structurally related alkyl esters due to having the shortest duration of action and the most similar pharmacological profile to ketamine itself.<ref>{{cite journal | vauthors = Jose J, Gamage SA, Harvey MG, Voss LJ, Sleigh JW, Denny WA | title = Structure-activity relationships for ketamine esters as short-acting anaesthetics | journal = Bioorganic & Medicinal Chemistry | volume = 21 | issue = 17 | pages = 5098–106 | date = September 2013 | pmid = 23876339 | doi = 10.1016/j.bmc.2013.06.047 }}</ref><ref>{{cite journal | vauthors = Harvey M, Sleigh J, Voss L, Jose J, Gamage S, Pruijn F, Liyanage S, Denny W | display-authors = 6 | title = Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs | journal = Anesthesia and Analgesia | volume = 121 | issue = 4 | pages = 925–33 | date = October 2015 | pmid = 25822925 | doi = 10.1213/ANE.0000000000000719 | s2cid = 23288200 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Harvey M, Sleigh J, Voss L, Pruijn F, Jose J, Gamage S, Denny W | title = Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210 | journal = Pharmacology | volume = 96 | issue = 5–6 | pages = 226–32 | year = 2015 | pmid = 26352278 | doi = 10.1159/000439598 | s2cid = 36017002 }}</ref><ref name="pmid30971208">{{cite journal | vauthors = Jacobson GM, Voss LJ, Klockars A, Bird S, Dimitrov I, Denny WA, Olszewski PK, Sleigh JW, Harvey MG | display-authors = 6 | title = Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain | journal = BMC Genomics | volume = 20 | issue = 1 | pages = 281 | date = April 2019 | pmid = 30971208 | pmc = 6458767 | doi = 10.1186/s12864-019-5649-6 | doi-access = free }}</ref><ref name="pmid31856925">{{cite journal | vauthors = Harvey M, Sleigh J, Voss L, Bickerdike M, Dimitrov I, Denny W | title = KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects | journal = BMC Pharmacology & Toxicology | volume = 20 | issue = 1 | pages = 85 | date = December 2019 | pmid = 31856925 | doi = 10.1186/s40360-019-0374-y | pmc = 6923863 | doi-access = free }}</ref>

== See also ==
* [A-NK](/source/A-NK)

== References ==
{{Reflist}}

{{Dissociatives}}
{{Ionotropic glutamate receptor modulators}}

Category:Arylcyclohexylamines
Category:Dissociative drugs
Category:NMDA receptor antagonists

{{Hallucinogen-stub}}

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Adapted from the Wikipedia article [SN 35210](https://en.wikipedia.org/wiki/SN_35210) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SN_35210?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.