# SEC62

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> Source: https://en.wikipedia.org/wiki/SEC62
> Source revision: 1301027174
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Translocation protein SEC62''' is a [protein](/source/protein) that in humans is encoded by the ''SEC62'' [gene](/source/gene).<ref name="pmid9020021">{{cite journal | vauthors = Daimon M, Susa S, Suzuki K, Kato T, Yamatani K, Sasaki H | title = Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1) | journal = Biochem Biophys Res Commun | volume = 230 | issue = 1 | pages = 100–4 |date=Feb 1997 | pmid = 9020021 | doi = 10.1006/bbrc.1996.5892 }}</ref><ref name="pmid10799540">{{cite journal | vauthors = Meyer HA, Grau H, Kraft R, Kostka S, Prehn S, Kalies KU, Hartmann E | title = Mammalian Sec61 is associated with Sec62 and Sec63 | journal = J Biol Chem | volume = 275 | issue = 19 | pages = 14550–7 |date=Jun 2000 | pmid = 10799540 | doi =10.1074/jbc.275.19.14550  | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TLOC1 translocation protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7095}}</ref>

== Function ==

The [Sec61](/source/Sec61) complex is the central component of the protein translocation apparatus of the [endoplasmic reticulum](/source/endoplasmic_reticulum) (ER) membrane. The protein encoded by this gene and [SEC63](/source/SEC63) protein are found to be associated with [ribosome](/source/ribosome)-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the [ubiquitin](/source/ubiquitin)-[proteasome](/source/proteasome)-dependent degradation pathway. The encoded protein is an [integral membrane protein](/source/integral_membrane_protein) located in the rough ER.<ref name="entrez" />

==References==
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==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Daimon M, Susa S, Kato T |title=Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene |journal=IUBMB Life |volume=48 |issue= 6 |pages= 619–24 |year= 2000 |pmid= 10683767 |doi=10.1080/713803565  |s2cid=10297001 |doi-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Jung V, Kindich R, Kamradt J, etal |title=Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer |journal=Mol. Cancer Res. |volume=4 |issue= 3 |pages= 169–76 |year= 2006 |pmid= 16547154 |doi= 10.1158/1541-7786.MCR-05-0165 |doi-access= free }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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Adapted from the Wikipedia article [SEC62](https://en.wikipedia.org/wiki/SEC62) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SEC62?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.