# SCP2 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/SCP2 > Markdown URL: https://mediated.wiki/source/SCP2.md > Source: https://en.wikipedia.org/wiki/SCP2 > Source revision: 1338083866 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Protein}} {{Infobox_gene}} '''Non-specific lipid-transfer protein''' also known as '''sterol carrier protein 2''' (SCP-2) or '''propanoyl-CoA C-acyltransferase''' is a [protein](/source/protein) that in humans is encoded by the ''SCP2'' [gene](/source/gene).{{cite journal | vauthors = Yamamoto R, Kallen CB, Babalola GO, Rennert H, Billheimer JT, Strauss JF | title = Cloning and expression of a cDNA encoding human sterol carrier protein 2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 2 | pages = 463–7 | date = January 1991 | pmid = 1703300 | pmc = 50831 | doi = 10.1073/pnas.88.2.463| bibcode = 1991PNAS...88..463Y | doi-access = free }}{{cite journal | vauthors = He Z, Yamamoto R, Furth EE, Schantz LJ, Naylor SL, George H, Billheimer JT, Strauss JF | title = cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21----pter | journal = DNA Cell Biol. | volume = 10 | issue = 8 | pages = 559–69 | date = October 1991 | pmid = 1718316 | doi = 10.1089/dna.1991.10.559 }} == Function == This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common [C-terminus](/source/C-terminus). Evidence suggests that the SCPx protein is a [peroxisome](/source/peroxisome)-associated [thiolase](/source/thiolase) that is involved in the oxidation of [branched chain fatty acid](/source/branched_chain_fatty_acid)s, while the SCP2 protein is thought to be an intracellular lipid transfer protein. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.{{cite web | title = Entrez Gene: SCP2 sterol carrier protein 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6342}} == Clinical significance == This gene is highly expressed in organs involved in lipid metabolism, and may play a role in [Zellweger syndrome](/source/Zellweger_syndrome), in which cells are deficient in peroxisomes and have impaired [bile acid](/source/bile_acid) synthesis. ==Interactions== SCP2 has been shown to [interact](/source/Protein-protein_interaction) with [Caveolin 1](/source/Caveolin_1){{cite journal | vauthors = Zhou M, Parr RD, Petrescu AD, Payne HR, Atshaves BP, Kier AB, Ball JM, Schroeder F | title = Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo | journal = Biochemistry | volume = 43 | issue = 23 | pages = 7288–306 | date = June 2004 | pmid = 15182174 | doi = 10.1021/bi035914n | url = https://scholarworks.sfasu.edu/biology/44 | url-access = subscription }} and peroxisomal receptor [PEX5](/source/PEX5).{{cite journal | vauthors = Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M | title = Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p | journal = Mol. Cell | volume = 24 | issue = 5 | pages = 653–63 | date = December 2006 | pmid = 17157249 | pmc = 5030714 | doi = 10.1016/j.molcel.2006.10.024}} ==References== {{reflist}} ==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Seedorf U, Ellinghaus P, Roch Nofer J |title=Sterol carrier protein-2 |journal=Biochim. Biophys. Acta |volume=1486 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10856712 |doi= 10.1016/s1388-1981(00)00047-0}} *{{cite journal |vauthors=Gallegos AM, Atshaves BP, Storey SM, etal |title=Gene structure, intracellular localization, and functional roles of sterol carrier protein-2 |journal=Prog. Lipid Res. |volume=40 |issue= 6 |pages= 498–563 |year= 2001 |pmid= 11591437 |doi=10.1016/S0163-7827(01)00015-7 }} *{{cite journal | author=Yamamoto R |title=[Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell] |journal=Hokkaido Igaku Zasshi |volume=67 |issue= 6 |pages= 839–48 |year= 1993 |pmid= 1483685 }} *{{cite journal |vauthors=Baker ME, Billheimer JT, Strauss JF |title=Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx |journal=DNA Cell Biol. |volume=10 |issue= 9 |pages= 695–8 |year= 1992 |pmid= 1755959 |doi=10.1089/dna.1991.10.695 }} *{{cite journal |vauthors=Schroeder F, Butko P, Nemecz G, Scallen TJ |title=Interaction of fluorescent delta 5,7,9(11),22-ergostatetraen-3 beta-ol with sterol carrier protein-2 |journal=J. Biol. Chem. |volume=265 |issue= 1 |pages= 151–7 |year= 1990 |doi=10.1016/S0021-9258(19)40208-1 |pmid= 2294101 |doi-access=free }} *{{cite journal |vauthors=Ohba T, Holt JA, Billheimer JT, Strauss JF |title=Human sterol carrier protein x/sterol carrier protein 2 gene has two promoters |journal=Biochemistry |volume=34 |issue= 33 |pages= 10660–8 |year= 1995 |pmid= 7654720 |doi=10.1021/bi00033a042 }} *{{cite journal |vauthors=Ohba T, Rennert H, Pfeifer SM, etal |title=The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2) |journal=Genomics |volume=24 |issue= 2 |pages= 370–4 |year= 1995 |pmid= 7698762 |doi= 10.1006/geno.1994.1630 |doi-access= free }} *{{cite journal |vauthors=Woodford JK, Colles SM, Myers-Payne S, etal |title=Sterol carrier protein-2 stimulates intermembrane sterol transfer by direct membrane interaction |journal=Chem. Phys. Lipids |volume=76 |issue= 1 |pages= 73–84 |year= 1995 |pmid= 7788802 |doi=10.1016/0009-3084(95)02436-M }} *{{cite journal |vauthors=Vesa J, Hellsten E, Barnoski BL, etal |title=Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 341–6 |year= 1994 |pmid= 8004106 |doi=10.1093/hmg/3.2.341 }} *{{cite journal |vauthors=Seedorf U, Brysch P, Engel T, etal |title=Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 21277–83 |year= 1994 |doi=10.1016/S0021-9258(17)31960-9 |pmid= 8063752 |doi-access=free }} *{{cite journal |vauthors=Szyperski T, Scheek S, Johansson J, etal |title=NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2 |journal=FEBS Lett. |volume=335 |issue= 1 |pages= 18–26 |year= 1993 |pmid= 8243660 |doi=10.1016/0014-5793(93)80431-S |bibcode=1993FEBSL.335...18S |s2cid=9969358 |doi-access=free }} *{{cite journal |vauthors=Seedorf U, Scheek S, Engel T, etal |title=Structure-activity studies of human sterol carrier protein 2 |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2613–8 |year= 1994 |doi=10.1016/S0021-9258(17)41988-0 |pmid= 8300590 |doi-access=free }} *{{cite journal |vauthors=Yanase T, Hara T, Sakai Y, etal |title=Expression of sterol carrier protein 2 (SCP2) in human adrenocortical tissue |journal=Eur. J. Endocrinol. |volume=134 |issue= 4 |pages= 501–7 |year= 1996 |pmid= 8640304 |doi=10.1530/eje.0.1340501 }} *{{cite journal |vauthors=Stolowich NJ, Frolov A, Atshaves B, etal |title=The sterol carrier protein-2 fatty acid binding site: an NMR, circular dichroic, and fluorescence spectroscopic determination |journal=Biochemistry |volume=36 |issue= 7 |pages= 1719–29 |year= 1997 |pmid= 9048555 |doi= 10.1021/bi962317a }} *{{cite journal |vauthors=Schalk JA, Offenberg HH, Peters E, etal |title=Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 642–4 |year= 1999 |pmid= 10341103 |doi=10.1007/s003359901062 |s2cid=9107396 }} *{{cite journal |vauthors=Jatzke C, Hinz HJ, Seedorf U, Assmann G |title=Stability and binding properties of wild-type and c17s mutated human sterol carrier protein 2 |journal=Biochim. Biophys. Acta |volume=1432 |issue= 2 |pages= 265–74 |year= 1999 |pmid= 10407148 |doi=10.1016/S0167-4838(99)00114-4 }} *{{cite journal |vauthors=Kimura H, Fujii H, Suzuki S, etal |title=Lipid-binding proteins in rat and human kidney |journal=Kidney Int. Suppl. |volume=71 |pages= S159–62 |year= 1999 |pmid= 10412765 |doi=10.1046/j.1523-1755.1999.07141.x |doi-access=free }} *{{cite journal |vauthors=Huang H, Ball JM, Billheimer JT, Schroeder F |title=The sterol carrier protein-2 amino terminus: a membrane interaction domain |journal=Biochemistry |volume=38 |issue= 40 |pages= 13231–43 |year= 1999 |pmid= 10529196 |doi=10.1021/bi990870x }} {{refend}} {{PDB Gallery|geneid=6342}} {{Acyltransferases}} {{Enzymes}} {{Portal bar|Biology|border=no}} Category:EC 2.3.1 {{gene-1-stub}} --- Adapted from the Wikipedia article [SCP2](https://en.wikipedia.org/wiki/SCP2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SCP2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.