# SCARB1

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Mammalian protein

SCARB1 Identifiers Aliases SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, scavenger receptor class B member 1 External IDs OMIM: 601040; MGI: 893578; HomoloGene: 21132; GeneCards: SCARB1; OMA:SCARB1 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 124,776,856 bp[1] End 124,882,668 bp[1] Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 64.11 cM|5 G1.1 Start 125,354,151 bp[2] End 125,418,158 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver left ovary right ovary putamen caudate nucleus subcutaneous adipose tissue placenta Top expressed in adrenal gland cumulus cell retinal pigment epithelium Gonadal ridge external carotid artery internal carotid artery neural layer of retina lactiferous gland yolk sac ciliary body More reference expression data BioGPS More reference expression data Gene ontology Molecular function apolipoprotein binding protein homodimerization activity virus receptor activity transporter activity high-density lipoprotein particle receptor activity phosphatidylserine binding apolipoprotein A-I binding lipopolysaccharide binding low-density lipoprotein particle binding 1-phosphatidylinositol binding protein binding high-density lipoprotein particle binding lipopolysaccharide immune receptor activity amyloid-beta binding scavenger receptor activity Cellular component cytoplasm integral component of membrane endocytic vesicle membrane intracellular membrane-bounded organelle membrane plasma membrane integral component of plasma membrane cell surface lysosomal membrane caveola extracellular exosome microvillus membrane Biological process cholesterol import positive regulation of triglyceride biosynthetic process regulation of phosphatidylcholine catabolic process recognition of apoptotic cell lipid transport low-density lipoprotein particle clearance blood vessel endothelial cell migration positive regulation of cholesterol storage phospholipid transport cholesterol transport wound healing cholesterol catabolic process receptor-mediated endocytosis high-density lipoprotein particle remodeling positive regulation of endothelial cell migration androgen biosynthetic process vitamin transmembrane transport positive regulation of nitric-oxide synthase activity endothelial cell proliferation lipopolysaccharide transport cholesterol efflux phagocytosis, recognition viral entry into host cell intestinal absorption cholesterol homeostasis regulation of phagocytosis adhesion of symbiont to host viral process detection of lipopolysaccharide triglyceride homeostasis reverse cholesterol transport lipopolysaccharide-mediated signaling pathway high-density lipoprotein particle clearance Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 949 20778 Ensembl ENSG00000073060 ENSMUSG00000037936 UniProt Q8WTV0 Q61009 RefSeq (mRNA) NM_005505 NM_001082959 NM_001205082 NM_001205083 NM_016741 RefSeq (protein) NP_001076428 NP_005496 NP_001354910 NP_001354911 NP_001354912 NP_001354913 NP_001354914 NP_001354915 NP_001354916 NP_001354917 NP_001354918 NP_001192011 NP_001192012 NP_058021 Location (UCSC) Chr 12: 124.78 – 124.88 Mb Chr 5: 125.35 – 125.42 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Scavenger receptor class B type 1** (SRB1) also known as **SR-BI** is a [protein](/source/Protein) that in humans is encoded by the *SCARB1* [gene](/source/Gene).[5] SR-BI functions as a receptor for [high-density lipoprotein](/source/High-density_lipoprotein).[6]

## Function

[Scavenger receptor](/source/Scavenger_receptor_(immunology)) class B, type I (**SR-BI**) is an [integral membrane protein](/source/Integral_membrane_protein) found in numerous cell types/tissues, including [enterocytes](/source/Enterocyte), the [liver](/source/Liver) and [adrenal](/source/Adrenal) gland. It is best known for its role in facilitating the uptake of [cholesteryl esters](/source/Cholesteryl_ester) from [high-density lipoproteins](/source/High-density_lipoprotein) in the liver. This process drives the movement of [cholesterol](/source/Cholesterol) from peripheral tissues towards the [liver](/source/Liver), where cholesterol can either be secreted via the bile duct or be used to synthesise steroid hormones.[7] This movement of [cholesterol](/source/Cholesterol) is known as [reverse cholesterol transport](/source/Reverse_cholesterol_transport) and is a protective mechanism against the development of [atherosclerosis](/source/Atherosclerosis), which is the principal cause of [heart disease](/source/Heart_disease) and [stroke](/source/Stroke).

SR-BI is crucial in [carotenoid](/source/Carotenoid) and [vitamin E](/source/Vitamin_E) uptake in the small intestine.[8][9] SR-B1 is upregulated in times of vitamin A deficiency and downregulated if vitamin A status is in the normal range.[10]

In melanocytic cells SCARB1 gene expression may be regulated by the [MITF](/source/Microphthalmia-associated_transcription_factor).[11]

## Species distribution

SR-BI has also been identified in the livers of non-mammalian species ([turtle](/source/Turtle), [goldfish](/source/Goldfish), [shark](/source/Shark), [chicken](/source/Chicken), [frog](/source/Frog), and [skate](/source/Skate_(fish))), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SR-BI during [egg development](/source/Spawn_(biology)#Egg_development), indicating that cholesterol efflux may be at peak levels during developmental stages.[12]

## Clinical significance

SCARB1 along with [CD81](/source/CD81) is the receptor for the entry of the [Hepatitis C virus](/source/Hepatitis_C_virus) into liver cells.[13]

## Preclinical research

Although malignant tumors are known to display extreme [heterogeneity](/source/Heterogeneity), overexpression of SR-B1 is a relatively consistent marker in cancerous tissues. While SR-B1 normally mediates the transfer of cholesterol between [high-density lipoproteins](/source/High-density_lipoprotein) (HDL) and healthy cells, it also facilitates the selective uptake of cholesterol by malignant cells. In this way, upregulation of the SR-B1 receptor becomes an enabling factor for self-sufficient [proliferation](/source/Cell_proliferation) in cancerous tissue.[14][15]

SR-B1 mediated delivery has also been used in the transfection of cancer cells with [siRNA](/source/SiRNA), or small interfering RNAs. This therapy causes [RNA interference](/source/RNA_interference), in which short segments of double stranded RNA acts to silence targeted [oncogenes](/source/Oncogenes) post-transcription. SR-B1 mediation reduces siRNA degradation and off-target accumulation while enhancing delivery to targeted tissues. In "metastatic and [taxane](/source/Taxane)-resistant models of ovarian cancer, rHDL-mediated siren delivery improved responses.[16]

## Interactive pathway map

*Click on genes, proteins and metabolites below to link to respective articles.*[§ 1]

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Statin pathway [edit](http://www.wikipathways.org/index.php/Pathway:WP430)

1. **[^](#cite_ref-WikiPathways_17-0)** The interactive pathway map can be edited at WikiPathways: ["Statin_Pathway_WP430"](http://www.wikipathways.org/index.php/Pathway:WP430).

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000073060](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000073060) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000037936](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000037936) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=949). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=20778). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-5)** ["Entrez Gene: SCARB1 Scavenger receptor class B, member 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=949).

1. **[^](#cite_ref-pmid8560269_6-0)** Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M (January 1996). "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor". *Science*. **271** (5248): 518–20. [Bibcode](/source/Bibcode_(identifier)):[1996Sci...271..518A](https://ui.adsabs.harvard.edu/abs/1996Sci...271..518A). [doi](/source/Doi_(identifier)):[10.1126/science.271.5248.518](https://doi.org/10.1126%2Fscience.271.5248.518). [PMID](/source/PMID_(identifier)) [8560269](https://pubmed.ncbi.nlm.nih.gov/8560269). [S2CID](/source/S2CID_(identifier)) [249922](https://api.semanticscholar.org/CorpusID:249922).

1. **[^](#cite_ref-pmid14592533_7-0)** Rhainds D, Brissette L (January 2004). "The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders". *The International Journal of Biochemistry & Cell Biology*. **36** (1): 39–77. [doi](/source/Doi_(identifier)):[10.1016/s1357-2725(03)00173-0](https://doi.org/10.1016%2Fs1357-2725%2803%2900173-0). [PMID](/source/PMID_(identifier)) [14592533](https://pubmed.ncbi.nlm.nih.gov/14592533).

1. **[^](#cite_ref-pmid22239457_8-0)** Valacchi G, Sticozzi C, Lim Y, Pecorelli A (July 2011). ["Scavenger receptor class B type I: a multifunctional receptor"](https://doi.org/10.1111%2Fj.1749-6632.2011.06205.x). *Annals of the New York Academy of Sciences*. **1229** (1): E1-7. [Bibcode](/source/Bibcode_(identifier)):[2011NYASA1229E...1V](https://ui.adsabs.harvard.edu/abs/2011NYASA1229E...1V). [doi](/source/Doi_(identifier)):[10.1111/j.1749-6632.2011.06205.x](https://doi.org/10.1111%2Fj.1749-6632.2011.06205.x). [PMID](/source/PMID_(identifier)) [22239457](https://pubmed.ncbi.nlm.nih.gov/22239457). [S2CID](/source/S2CID_(identifier)) [7844031](https://api.semanticscholar.org/CorpusID:7844031).

1. **[^](#cite_ref-9)** van Bennekum A, Werder M, Thuahnai ST, Han CH, Duong P, Williams DL, et al. (March 2005). "Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol". *Biochemistry*. **44** (11): 4517–25. [doi](/source/Doi_(identifier)):[10.1021/bi0484320](https://doi.org/10.1021%2Fbi0484320). [PMID](/source/PMID_(identifier)) [15766282](https://pubmed.ncbi.nlm.nih.gov/15766282).

1. **[^](#cite_ref-PKIN2020VitA_10-0)** Blaner WS (2020). "Vitamin A". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). *Present Knowledge in Nutrition, Eleventh Edition*. London, United Kingdom: Academic Press (Elsevier). pp. 73–92. [ISBN](/source/ISBN_(identifier)) [978-0-323-66162-1](https://en.wikipedia.org/wiki/Special:BookSources/978-0-323-66162-1).

1. **[^](#cite_ref-pmid19067971_11-0)** Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). ["Novel MITF targets identified using a two-step DNA microarray strategy"](https://doi.org/10.1111%2Fj.1755-148X.2008.00505.x). *Pigment Cell & Melanoma Research*. **21** (6): 665–76. [doi](/source/Doi_(identifier)):[10.1111/j.1755-148X.2008.00505.x](https://doi.org/10.1111%2Fj.1755-148X.2008.00505.x). [PMID](/source/PMID_(identifier)) [19067971](https://pubmed.ncbi.nlm.nih.gov/19067971). [S2CID](/source/S2CID_(identifier)) [24698373](https://api.semanticscholar.org/CorpusID:24698373).

1. **[^](#cite_ref-12)** Duggan AE, Marie RS, Callard IP (April 2002). "Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates". *The Journal of Experimental Zoology*. **292** (5): 430–4. [doi](/source/Doi_(identifier)):[10.1002/jez.10067](https://doi.org/10.1002%2Fjez.10067). [PMID](/source/PMID_(identifier)) [11857477](https://pubmed.ncbi.nlm.nih.gov/11857477).

1. **[^](#cite_ref-pmid17050612_13-0)** Kapadia SB, Barth H, Baumert T, McKeating JA, Chisari FV (January 2007). ["Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I"](https://web.archive.org/web/20170809023838/http://eprints.bham.ac.uk/487/1/Kapadia.pdf) (PDF). *Journal of Virology*. **81** (1): 374–83. [doi](/source/Doi_(identifier)):[10.1128/JVI.01134-06](https://doi.org/10.1128%2FJVI.01134-06). [PMC](/source/PMC_(identifier)) [1797271](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797271). [PMID](/source/PMID_(identifier)) [17050612](https://pubmed.ncbi.nlm.nih.gov/17050612). Archived from [the original](http://eprints.bham.ac.uk/487/1/Kapadia.pdf) (PDF) on 2017-08-09. Retrieved 2018-11-04.

1. **[^](#cite_ref-14)** Mooberry LK, Sabnis NA, Panchoo M, Nagarajan B, Lacko AG (December 2016). ["Targeting the SR-B1 Receptor as a Gateway for Cancer Therapy and Imaging"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156841). *Frontiers in Pharmacology*. **7** (466): 466. [doi](/source/Doi_(identifier)):[10.3389/fphar.2016.00466](https://doi.org/10.3389%2Ffphar.2016.00466). [PMC](/source/PMC_(identifier)) [5156841](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156841). [PMID](/source/PMID_(identifier)) [28018216](https://pubmed.ncbi.nlm.nih.gov/28018216).

1. **[^](#cite_ref-pmid27774064_15-0)** Gutierrez-Pajares JL, Ben Hassen C, Chevalier S, Frank PG (2016). ["SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054001). *Frontiers in Pharmacology*. **7**: 338. [doi](/source/Doi_(identifier)):[10.3389/fphar.2016.00338](https://doi.org/10.3389%2Ffphar.2016.00338). [PMC](/source/PMC_(identifier)) [5054001](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054001). [PMID](/source/PMID_(identifier)) [27774064](https://pubmed.ncbi.nlm.nih.gov/27774064).

1. **[^](#cite_ref-16)** Rajora MA, Zheng G (2016). ["Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037127). *Frontiers in Pharmacology*. **7** (Art. 326): 326. [doi](/source/Doi_(identifier)):[10.3389/fphar.2016.00326](https://doi.org/10.3389%2Ffphar.2016.00326). [PMC](/source/PMC_(identifier)) [5037127](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037127). [PMID](/source/PMID_(identifier)) [27729859](https://pubmed.ncbi.nlm.nih.gov/27729859).

## Further reading

- Williams DL, Temel RE, Connelly MA (November 2000). "Roles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cells". *Endocrine Research*. **26** (4): 639–51. [doi](/source/Doi_(identifier)):[10.3109/07435800009048584](https://doi.org/10.3109%2F07435800009048584). [PMID](/source/PMID_(identifier)) [11196441](https://pubmed.ncbi.nlm.nih.gov/11196441). [S2CID](/source/S2CID_(identifier)) [21441940](https://api.semanticscholar.org/CorpusID:21441940).

- Krause BR, Auerbach BJ (March 2001). "Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis". *Current Opinion in Investigational Drugs*. **2** (3): 375–81. [PMID](/source/PMID_(identifier)) [11575708](https://pubmed.ncbi.nlm.nih.gov/11575708).

- Connelly MA, Williams DL (June 2004). "Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids". *Current Opinion in Lipidology*. **15** (3): 287–95. [doi](/source/Doi_(identifier)):[10.1097/00041433-200406000-00008](https://doi.org/10.1097%2F00041433-200406000-00008). [PMID](/source/PMID_(identifier)) [15166784](https://pubmed.ncbi.nlm.nih.gov/15166784). [S2CID](/source/S2CID_(identifier)) [24035736](https://api.semanticscholar.org/CorpusID:24035736).

- Phillips RW (1978). "The new era in restorative dental materials". *Operative Dentistry*. **1** (1): 29–35. [PMID](/source/PMID_(identifier)) [1076467](https://pubmed.ncbi.nlm.nih.gov/1076467).

- Skre H, Berg K (1974). "Cerebellar ataxia and total albinism: a kindred suggesting pleitotropism or linkage". *Clinical Genetics*. **5** (3): 196–204. [doi](/source/Doi_(identifier)):[10.1111/j.1399-0004.1974.tb01682.x](https://doi.org/10.1111%2Fj.1399-0004.1974.tb01682.x). [PMID](/source/PMID_(identifier)) [4838888](https://pubmed.ncbi.nlm.nih.gov/4838888). [S2CID](/source/S2CID_(identifier)) [37259762](https://api.semanticscholar.org/CorpusID:37259762).

- Calvo D, Dopazo J, Vega MA (January 1995). "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution". *Genomics*. **25** (1): 100–6. [doi](/source/Doi_(identifier)):[10.1016/0888-7543(95)80114-2](https://doi.org/10.1016%2F0888-7543%2895%2980114-2). [PMID](/source/PMID_(identifier)) [7539776](https://pubmed.ncbi.nlm.nih.gov/7539776).

- Calvo D, Vega MA (September 1993). ["Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family"](https://doi.org/10.1016%2FS0021-9258%2817%2946716-0). *The Journal of Biological Chemistry*. **268** (25): 18929–35. [doi](/source/Doi_(identifier)):[10.1016/S0021-9258(17)46716-0](https://doi.org/10.1016%2FS0021-9258%2817%2946716-0). [PMID](/source/PMID_(identifier)) [7689561](https://pubmed.ncbi.nlm.nih.gov/7689561).

- Murao K, Terpstra V, Green SR, Kondratenko N, Steinberg D, Quehenberger O (July 1997). ["Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes"](https://doi.org/10.1074%2Fjbc.272.28.17551). *The Journal of Biological Chemistry*. **272** (28): 17551–7. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.28.17551](https://doi.org/10.1074%2Fjbc.272.28.17551). [PMID](/source/PMID_(identifier)) [9211901](https://pubmed.ncbi.nlm.nih.gov/9211901).

- Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K (June 2000). ["Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18651). *Proceedings of the National Academy of Sciences of the United States of America*. **97** (12): 6538–43. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...97.6538I](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.6538I). [doi](/source/Doi_(identifier)):[10.1073/pnas.100114397](https://doi.org/10.1073%2Fpnas.100114397). [PMC](/source/PMC_(identifier)) [18651](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18651). [PMID](/source/PMID_(identifier)) [10829064](https://pubmed.ncbi.nlm.nih.gov/10829064).

- Husemann J, Silverstein SC (March 2001). ["Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850374). *The American Journal of Pathology*. **158** (3): 825–32. [doi](/source/Doi_(identifier)):[10.1016/S0002-9440(10)64030-8](https://doi.org/10.1016%2FS0002-9440%2810%2964030-8). [PMC](/source/PMC_(identifier)) [1850374](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850374). [PMID](/source/PMID_(identifier)) [11238031](https://pubmed.ncbi.nlm.nih.gov/11238031).

- Li XA, Titlow WB, Jackson BA, Giltiay N, Nikolova-Karakashian M, Uittenbogaard A, Smart EJ (March 2002). ["High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner"](https://doi.org/10.1074%2Fjbc.M110985200). *The Journal of Biological Chemistry*. **277** (13): 11058–63. [doi](/source/Doi_(identifier)):[10.1074/jbc.M110985200](https://doi.org/10.1074%2Fjbc.M110985200). [PMID](/source/PMID_(identifier)) [11792700](https://pubmed.ncbi.nlm.nih.gov/11792700).

- Duncan KG, Bailey KR, Kane JP, Schwartz DM (April 2002). "Human retinal pigment epithelial cells express scavenger receptors BI and BII". *Biochemical and Biophysical Research Communications*. **292** (4): 1017–22. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2002.6756](https://doi.org/10.1006%2Fbbrc.2002.6756). [PMID](/source/PMID_(identifier)) [11944916](https://pubmed.ncbi.nlm.nih.gov/11944916).

- Kawasaki Y, Nakagawa A, Nagaosa K, Shiratsuchi A, Nakanishi Y (July 2002). ["Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells"](https://doi.org/10.1074%2Fjbc.M202879200). *The Journal of Biological Chemistry*. **277** (30): 27559–66. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202879200](https://doi.org/10.1074%2Fjbc.M202879200). [PMID](/source/PMID_(identifier)) [12016218](https://pubmed.ncbi.nlm.nih.gov/12016218).

- Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ (August 2002). ["Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha"](https://doi.org/10.1074%2Fjbc.M201053200). *The Journal of Biological Chemistry*. **277** (32): 28624–30. [doi](/source/Doi_(identifier)):[10.1074/jbc.M201053200](https://doi.org/10.1074%2Fjbc.M201053200). [PMID](/source/PMID_(identifier)) [12039952](https://pubmed.ncbi.nlm.nih.gov/12039952).

- Johnson MS, Svensson PA, Borén J, Billig H, Carlsson LM, Carlsson B (June 2002). "Expression of scavenger receptor class B type I in gallbladder columnar epithelium". *Journal of Gastroenterology and Hepatology*. **17** (6): 713–20. [doi](/source/Doi_(identifier)):[10.1046/j.1440-1746.2002.02776.x](https://doi.org/10.1046%2Fj.1440-1746.2002.02776.x). [PMID](/source/PMID_(identifier)) [12100619](https://pubmed.ncbi.nlm.nih.gov/12100619). [S2CID](/source/S2CID_(identifier)) [21584794](https://api.semanticscholar.org/CorpusID:21584794).

- Silver DL (September 2002). ["A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver"](https://doi.org/10.1074%2Fjbc.M206584200). *The Journal of Biological Chemistry*. **277** (37): 34042–7. [doi](/source/Doi_(identifier)):[10.1074/jbc.M206584200](https://doi.org/10.1074%2Fjbc.M206584200). [PMID](/source/PMID_(identifier)) [12119305](https://pubmed.ncbi.nlm.nih.gov/12119305).

- Bultel-Brienne S, Lestavel S, Pilon A, Laffont I, Tailleux A, Fruchart JC, Siest G, Clavey V (September 2002). ["Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins"](https://doi.org/10.1074%2Fjbc.M201943200). *The Journal of Biological Chemistry*. **277** (39): 36092–9. [doi](/source/Doi_(identifier)):[10.1074/jbc.M201943200](https://doi.org/10.1074%2Fjbc.M201943200). [PMID](/source/PMID_(identifier)) [12138091](https://pubmed.ncbi.nlm.nih.gov/12138091).

- Strauss JG, Zimmermann R, Hrzenjak A, Zhou Y, Kratky D, Levak-Frank S, Kostner GM, Zechner R, Frank S (November 2002). ["Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222966). *The Biochemical Journal*. **368** (Pt 1): 69–79. [doi](/source/Doi_(identifier)):[10.1042/BJ20020306](https://doi.org/10.1042%2FBJ20020306). [PMC](/source/PMC_(identifier)) [1222966](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222966). [PMID](/source/PMID_(identifier)) [12164779](https://pubmed.ncbi.nlm.nih.gov/12164779).

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Adapted from the Wikipedia article [SCARB1](https://en.wikipedia.org/wiki/SCARB1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/SCARB1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.