# RsaOG

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**RsaOG** (an acronym for [RNA](/source/RNA) *[S. aureus](/source/S._aureus)* [Orsay](/source/Orsay) G)[1] is a [non-coding RNA](/source/Non-coding_RNA) that was discovered in the [pathogenic](/source/Pathogenic) bacteria *Staphylococcus aureus* N315 using a large-scale [computational screening](/source/Bioinformatics) based on [phylogenetic](/source/Phylogenetic) profiling.[2] It was first identified, but not named, in 2005.[3] RsaOG has since been identified in other strains of *Staphylococcus aureus* under the name of [RsaI](/source/Rsa_RNA),[4] it has also been discovered in other members of the *[Staphylococcus](/source/Staphylococcus)* [genus](/source/Genus) (such as *[Staphylococcus carnosus](/source/Staphylococcus_carnosus)*) but in no other bacteria.[1]

The RsaOG gene is [conserved](/source/Conserved_sequence) in all Staphylococcaceae sequenced [genomes](/source/Genome), its [secondary structure](/source/Secondary_structure) contains two highly conserved [unpaired sequences](/source/Base_pair) which have the ability to form a [pseudoknot](/source/Pseudoknot).[1] [Northern blot](/source/Northern_blot) experiments show that RsaOG is expressed in several *S. aureus* strains.[2][4] Mapping of RsaOG ends indicates a size of 146 [nucleotides](/source/Nucleotide) in *S. aureus*.[4] RsaOG ncRNA is thought to have [trans-acting](/source/Trans-acting) regulatory functions, possibly on fine-tuning [toxin](/source/Toxin) production or aiding with [invasion](/source/Infection).[1]

## See also

- [Rsa RNA](/source/Rsa_RNA)
- [Pathogenicity island](/source/Pathogenicity_island)
- [Bacterial small RNA](/source/Bacterial_small_RNA)

## References

1. Marchais A, Bohn C, Bouloc P, Gautheret D (March 2010). ["RsaOG, a new staphylococcal family of highly transcribed non-coding RNA"](http://www.landesbioscience.com/journals/rna/abstract.php?id=10925). *RNA Biol*. **7** (2): 116–119. [doi:10.4161/rna.7.2.10925](https://doi.org/10.4161/rna.7.2.10925). [PMID 20200491](https://pubmed.ncbi.nlm.nih.gov/20200491). Retrieved 2010-07-12.

1. Marchais A, Naville M, Bohn C, Bouloc P, Gautheret D (June 2009). "Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles". *Genome Res.*. **19** (6): 1084–1092. [doi:10.1101/gr.089714.108](https://doi.org/10.1101/gr.089714.108). [PMC 2694484](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694484). [PMID 19237465](https://pubmed.ncbi.nlm.nih.gov/19237465)

1. Pichon C, Felden B (October 2005). "Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". *Proc. Natl. Acad. Sci. U.S.A.*. **102** (40): 14249–14254. [doi:10.1073/pnas.0503838102](https://doi.org/10.1073/pnas.0503838102). [PMC 1242290](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242290). [PMID 16183745](https://pubmed.ncbi.nlm.nih.gov/16183745)

1. Geissmann T, Chevalier C, Cros MJ, etal (November 2009). "A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation". *Nucleic Acids Res.*. **37** (21): 7239–7257. [doi:10.1093/nar/gkp668](https://doi.org/10.1093/nar/gkp668). [PMC 2790875](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790875). [PMID 19786493](https://pubmed.ncbi.nlm.nih.gov/19786493)

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