# Rs6311

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Rs6311
> Markdown URL: https://mediated.wiki/source/Rs6311.md
> Source: https://en.wikipedia.org/wiki/Rs6311
> Source revision: 1294701573
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Infobox single nucleotide polymorphism
 | rsid = 6311
 | name_1 = -1438G/A
 | name_2 = -1438A/G
 | name_3 = A-1438G
 | name_4 = G-1438A
 | gene = HTR2A
 | chromosome = 13
 | szgene_geneid = 293
 | szgene_polyid = 1871
}}
In [genetics](/source/genetics), '''rs6311''' is a gene variation—a [single nucleotide polymorphism](/source/single_nucleotide_polymorphism) (SNP)—in the human ''[HTR2A](/source/HTR2A)'' [gene](/source/gene) that codes for the [5-HT<sub>2A</sub>](/source/5-HT2A) [receptor](/source/receptor_(biology)). 5-HT<sub>2A</sub> is a [neuroreceptor](/source/neuroreceptor), and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the [Temperament and Character Inventory](/source/Temperament_and_Character_Inventory)<ref>{{Cite journal
 |vauthors=Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS | title = Serotonergic genes and personality traits in the Korean population
 | journal = Neurosci. Lett.
 | volume = 354
 | issue = 1
 | pages = 2–5
 |date=January 2004
 | pmid = 14698468
 | doi = 10.1016/S0304-3940(03)00753-5
| s2cid = 22448256
 }}</ref><ref name="GieglingI2006Anger">{{Cite journal
 |vauthors=Giegling I, Hartmann AM, Möller HJ, Rujescu D | title = Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene
 | journal = [Journal of Affective Disorders](/source/Journal_of_Affective_Disorders)
 | volume = 96
 |date=November 2006
 | pages = 75–81
 | doi = 10.1016/j.jad.2006.05.016
 | issue = 1–2
 | pmid = 16814396
}}</ref><ref>{{Cite journal
 |vauthors=Unschuld PG, Ising M, Erhardt A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME | title = Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
 | journal = [Am J Med Genet B](/source/Am_J_Med_Genet_B)
 | volume = 144B
 | issue = 4
 | pages = 424–429
 |date=June 2007
 | doi = 10.1002/ajmg.b.30412
 | pmid = 17440930
| s2cid = 10374372
 }}</ref><ref>{{Cite journal
 |vauthors=Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C, Rujescu D | title = 5-HT<sub>2A</sub> SNPs and the Temperament and Character Inventory
 | journal = [Progress in Neuro-Psychopharmacology and Biological Psychiatry](/source/Progress_in_Neuro-Psychopharmacology_and_Biological_Psychiatry)
 | volume = 31
 | issue = 6
 |date=August 2007
 | pages = 1275–1281
 | doi = 10.1016/j.pnpbp.2007.05.008
 | pmid = 17590256
| s2cid = 2646380
 }}</ref>
or with a psychological task measuring impulsive behavior.<ref>{{Cite journal
 |vauthors=Nomura M, Kusumi I, Kaneko M, Masui T, Daiguji M, Ueno T, Koyama T, Nomura Y | title = Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
 | journal = Psychopharmacology
 | volume = 187
 | issue = 1
 | pages = 30–35
 |date=July 2006
 | doi = 10.1007/s00213-006-0398-z
 | pmid = 16767413
| s2cid = 12155339
 }}</ref>
The SNP has also been investigated in [rheumatology](/source/rheumatology) studies.<ref>{{Cite journal
 |vauthors=Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, Canturk F | title = Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility
 | journal = [Rheumatology International](/source/Rheumatology_International)
 | volume = 28
 | issue = 7
 |date=May 2008
 | pages = 685–691
 | doi = 10.1007/s00296-008-0525-8
 | pmid = 18196244
| s2cid = 29817254
 }}</ref><ref>{{Cite journal
 |vauthors=Kling A, Seddighzadeh M, Ärlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L | title = Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis
 | journal = [Ann. Rheum. Dis.](/source/Ann._Rheum._Dis.)
 | year = 2007
 | doi = 10.1136/ard.2007.074948
 | pmid = 18006541
 | volume = 67
 | pages = 1111–5
 | issue = 8
| s2cid = 3081132
 | doi-access = free
 }}</ref>

Some research studies may refer to this gene variation as a C/T SNP,<ref name="GieglingI2006Anger"/> while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.<ref>{{Cite journal
 |vauthors=Reynolds CA, Jansson M, Gatz M, Pedersen NL | title = Longitudinal change in memory performance associated with ''HTR2A'' polymorphism
 | journal = [Neurobiology of Aging](/source/Neurobiology_of_Aging)
 | volume = 27
 | issue = 1
 |date=January 2006
 | pages = 150–154
 | doi = 10.1016/j.neurobiolaging.2004.12.009
 | pmid = 16298250
| s2cid = 32745716
 }}</ref><ref>{{Cite journal
 |vauthors=Halder I, Muldoon MF, Ferrell RE, Manuck SB | title = Serotonin Receptor 2A (''HTR2A'') Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome
 | journal = [Metabolic Syndrome and Related Disorders](/source/Metabolic_Syndrome_and_Related_Disorders)
 |date=December 2007
 | volume = 5
 | issue = 4
 | pages = 323–330
 | doi = 10.1089/met.2007.0008
 | pmid = 18370802
 | pmc=3237193
}}</ref><ref>{{Cite journal
 |vauthors=Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Bascaran MT, Martinez-Barrondo S, Florez G, Sotomayor E, Paredes B, Alvarez C, San Narciso G, Carreño E, Bombin I, Alvarez V, Coto E, Fernandez JM, Bousoño M, Bobes J | title = Association study between obsessive–compulsive disorder and serotonergic candidate genes
 | journal = [Progress in Neuro-Psychopharmacology and Biological Psychiatry](/source/Progress_in_Neuro-Psychopharmacology_and_Biological_Psychiatry)
 | volume = 32
 | issue = 3
 |date=April 2008
 | pages = 765–770
 | doi = 10.1016/j.pnpbp.2007.12.005
 | pmid = 18191318
| s2cid = 35024576
 | hdl = 10651/6338
 | hdl-access = free
 }}</ref>

{{As of|2008}}, [meta-analysis](/source/meta-analysis) of research studies indicates that people with the A-[allele](/source/allele) may have slightly elevated risk of [schizophrenia](/source/schizophrenia).<ref>{{Cite web
 | url = http://www.schizophreniaforum.org/res/sczgene/meta.asp?geneID=293
 | archive-url = https://archive.today/20130415183845/http://www.schizophreniaforum.org/res/sczgene/meta.asp?geneID=293
 | url-status = dead
 | archive-date = April 15, 2013
 | title = Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6311
 | publisher = [Schizophrenia Research Forum](/source/Schizophrenia_Research_Forum)
 | access-date = 2008-06-10
 }}</ref>

[rs6313](/source/rs6313), [rs6314](/source/rs6314), and [rs7997012](/source/rs7997012) are other investigated SNPs in the HTR2A gene.

==References==
{{Reflist|2}}

Category:SNPs on chromosome 13

{{genetics-stub}}

---
Adapted from the Wikipedia article [Rs6311](https://en.wikipedia.org/wiki/Rs6311) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Rs6311?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.