# Robert A. Bonomo

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American physician and researcher

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Robert A. Bonomo Born Bronx, New York, U.S. Alma mater Hamilton College (B.A.) Case Western Reserve University (M.D.) Known for Research on antimicrobial resistance and β-lactamases Scientific career Fields Infectious diseases, microbiology Institutions Case Western Reserve University Louis Stokes Veterans Affairs Medical Center

**Robert Anthony Bonomo** is an American physician, researcher, and academic known for his work on [antimicrobial resistance](/source/Antimicrobial_resistance). He is a Distinguished University Professor at [Case Western Reserve University School of Medicine](/source/Case_Western_Reserve_University_School_of_Medicine), and serves as Associate Chief of Staff for Faculty Affairs and Chief Academic Officer at the Louis Stokes Cleveland [Veterans Affairs Medical Center](/source/Veterans_Affairs_Medical_Center).

## Early life and education

Bonomo was born in the Bronx, New York. He earned a Bachelor of Arts degree from [Hamilton College](/source/Hamilton_College) in 1976 and a Doctor of Medicine (M.D.) from [Case Western Reserve University](/source/Case_Western_Reserve_University) in 1983. He completed residency training in internal medicine at [University Hospitals of Cleveland](/source/University_Hospitals_of_Cleveland), followed by a fellowship in infectious diseases.[1]

## Career

Bonomo began his career in internal medicine and geriatrics before focusing on infectious diseases. Since the 1990s[2] he has worked at the Louis Stokes Veterans Affairs Medical Center, where he has served as Chief of Medicine from 2011 to 2020, Director of the Geriatric Research, Education and Clinical Center,[3] and Director of the Case Western Reserve University–Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case-VA CARES).[4]

At Case Western Reserve University, he has held faculty appointments across multiple departments, including medicine, pharmacology, microbiology, biochemistry, and bioinformatics. He was named Distinguished University Professor in 2019.[5]

## Research

Bonomo's research centers on the molecular mechanisms of antibiotic resistance, with a focus on β-lactamases and penicillin-binding proteins in pathogens such as *Klebsiella pneumoniae*,[6] *Acinetobacter baumannii*,[7] and *Pseudomonas aeruginosa*. His laboratory has contributed to structural and functional studies of β-lactamase enzymes, the development of β-lactamase inhibitors,[8][9] and molecular diagnostics for multidrug-resistant organisms.

He has authored more than 700 peer-reviewed scientific papers and is listed as a co-inventor on several patents for novel antimicrobial agents.

## Honors and awards

- 2024 - Maxwell Finland Lecture, [Infectious Diseases Society of America](/source/Infectious_Diseases_Society_of_America)[10]

- 2020 - Wolcott Award for Excellence in Clinical Care Leadership, VA Healthcare System[11]

- 2019-2023 - [Clarivate Highly Cited Researcher](/source/Highly_Cited_Researchers)[12]

- 2017 - [William S. Middleton Award](/source/William_S._Middleton_Award), [Veterans Health Administration](/source/Veterans_Health_Administration)[13]

- 2016 - Excellence in Clinical Microbiology and Infectious Diseases Award, [European Society of Clinical Microbiology and Infectious Diseases](/source/European_Society_of_Clinical_Microbiology_and_Infectious_Diseases)[14]

- 2011 - Fellow, [American Academy of Microbiology](/source/American_Academy_of_Microbiology)[15]

- Fellow, [Infectious Diseases Society of America](/source/Infectious_Diseases_Society_of_America)

- Fellow, [European Society of Clinical Microbiology and Infectious Diseases](/source/European_Society_of_Clinical_Microbiology_and_Infectious_Diseases)[16]

## References

1. **[^](#cite_ref-1)** ["Internal Medicine Residency Robert A. Bonomo, MD | Graduate Medical Education | University Hospitals | Cleveland, OH"](https://www.uhhospitals.org/medical-education/medicine/internal-medicine-residency/leadership/robert-bonomo-md). *University Hospitals*.

1. **[^](#cite_ref-2)** ["The Cleveland VA and Case Western Reserve Collaborate to Fight Drug-Resistant Bacteria"](https://www.ideastream.org/news/health-science/2017-03-13/the-cleveland-va-and-case-western-reserve-collaborate-to-fight-drug-resistant-bacteria). *Ideastream Public Media*. 14 March 2017.

1. **[^](#cite_ref-3)** ["Cleveland GRECC - Geriatric Research Education and Clinical Center (GRECC)"](https://www.va.gov/GRECC/Cleveland_GRECC.asp). *Va.gov*.

1. **[^](#cite_ref-4)** ["Robert Bonomo to Lead Coordinating Center for VA SHIELD"](https://arlg.org/robert-bonomo-to-lead-coordinating-center-for-va-shield/). *ARLG*. 13 May 2022.

1. **[^](#cite_ref-5)** ["Robert Bonomo, antibiotic resistance expert, awarded Distinguished University Professorship | CWRU Newsroom | Case Western Reserve University"](https://case.edu/news/robert-bonomo-antibiotic-resistance-expert-awarded-distinguished-university-professorship). *Case.edu*. 23 May 2025.

1. **[^](#cite_ref-6)** J, Rojas, Laura; M, Weinstock, George; Lorena, Diaz; Rafael, Rios; M, Hanson, Blake; S, Brown, Joseph; Purva, Vats; S, Phillips, Daniel; Hoan, Nguyen; M, Hujer, Kristine; Adriana, Correa; D, Adams, Mark; Federico, Perez; Erica, Sodergren; Apurva, Narechania; J, Planet, Paul; V, Villegas, Maria; A, Bonomo, Robert; A, Arias, Cesar (1 January 2018). ["An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the "Perfect Storm""](https://academic.oup.com/jid/article/217/1/82/4259398). *The Journal of Infectious Diseases*. **217** (1). [doi](/source/Doi_(identifier)):[10.1093/infdi](https://doi.org/10.1093%2Finfdi) (inactive 3 November 2025). [ISSN](/source/ISSN_(identifier)) [0022-1899](https://search.worldcat.org/issn/0022-1899).{{[cite journal](https://en.wikipedia.org/wiki/Template:Cite_journal)}}: CS1 maint: DOI inactive as of November 2025 ([link](https://en.wikipedia.org/wiki/Category:CS1_maint:_DOI_inactive_as_of_November_2025)) CS1 maint: multiple names: authors list ([link](https://en.wikipedia.org/wiki/Category:CS1_maint:_multiple_names:_authors_list))

1. **[^](#cite_ref-7)** Mack, Andrew R.; Hujer, Andrea M.; Mojica, Maria F.; Taracila, Magdalena A.; Feldgarden, Michael; Haft, Daniel H.; Klimke, William; Prasad, Arjun B.; Bonomo, Robert A. (5 March 2025). ["β-Lactamase diversity in Acinetobacter baumannii"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881555). *Antimicrobial Agents and Chemotherapy*. **69** (3): e0078424. [doi](/source/Doi_(identifier)):[10.1128/aac.00784-24](https://doi.org/10.1128%2Faac.00784-24). [ISSN](/source/ISSN_(identifier)) [1098-6596](https://search.worldcat.org/issn/1098-6596). [PMC](/source/PMC_(identifier)) [11881555](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881555). [PMID](/source/PMID_(identifier)) [39927782](https://pubmed.ncbi.nlm.nih.gov/39927782).

1. **[^](#cite_ref-8)** Bonomo, Robert A. (3 January 2017). ["β-Lactamases: A Focus on Current Challenges"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204326). *Cold Spring Harbor Perspectives in Medicine*. **7** (1) a025239. [doi](/source/Doi_(identifier)):[10.1101/cshperspect.a025239](https://doi.org/10.1101%2Fcshperspect.a025239). [ISSN](/source/ISSN_(identifier)) [2157-1422](https://search.worldcat.org/issn/2157-1422). [PMC](/source/PMC_(identifier)) [5204326](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204326). [PMID](/source/PMID_(identifier)) [27742735](https://pubmed.ncbi.nlm.nih.gov/27742735).

1. **[^](#cite_ref-9)** ["A Themed Issue in Honor of Professor Robert A. Bonomo—Outstanding Contributions in the Fields of ß-Lactamase Inhibitors"](https://www.mdpi.com/journal/antibiotics/special_issues/Q3K6I3A6UL). MDPI.

1. **[^](#cite_ref-10)** ["Maxwell Finland Lecture"](https://www.idsociety.org/about-us/lecturers/maxwell-finland-lecture/). *Idsociety.org*.

1. **[^](#cite_ref-11)** ["2020 Wolcott Award Goes to Robert A. Bonomo, MD"](https://arlg.org/2020-wolcott-award-goes-to-robert-a-bonomo-md/). *ARLG*. 17 January 2020.

1. **[^](#cite_ref-12)** ["Editorial Board Members from Antibiotics Featured in the 2023 Highly Cited Researchers List Published by Clarivate"](https://www.mdpi.com/about/announcements/7132). Mdpi.com.

1. **[^](#cite_ref-13)** ["William S. Middleton Award"](https://www.research.va.gov/isrm/blrd/middleton.cfm#2017). *Va.gov*. 17 June 2025.

1. **[^](#cite_ref-14)** ["Prof. Robert A. Bonomo received the ESCMID Award"](https://biotechinfo.fr/article/prof-robert-a-bonomo-received-the-escmid-award/). *Biotech.info* (in French).

1. **[^](#cite_ref-15)** ["ASM Directory Search Results"](https://myasm.asm.org/eweb/DynamicPage.aspx?Site=ASM&WebKey=abbcf18d-3f11-46a6-95d7-956eed2a9cf3&type=acfellows&FromSearchControl=Yes). *ASM*.

1. **[^](#cite_ref-16)** ["ESCMID Fellows"](https://www.escmid.org/about-us/network/escmid-fellows/). *ESCMID*.

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