# RTN1

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Protein-coding gene in the species Homo sapiens

RTN1 Identifiers Aliases RTN1, NSP, reticulon 1 External IDs OMIM: 600865; MGI: 1933947; HomoloGene: 49654; GeneCards: RTN1; OMA:RTN1 - orthologs Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 59,595,976 bp[1] End 59,870,776 bp[1] Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 72,258,526 bp[2] End 72,455,828 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell pons orbitofrontal cortex cerebellar vermis middle temporal gyrus superior frontal gyrus occipital lobe pars compacta parietal lobe Top expressed in dentate gyrus of hippocampal formation granule cell perirhinal cortex entorhinal cortex CA3 field superior frontal gyrus central gray substance of midbrain subiculum nucleus of stria terminalis primary visual cortex cingulate gyrus More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Golgi membrane Golgi apparatus Biological process neuron differentiation Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 6252 104001 Ensembl ENSG00000139970 ENSMUSG00000021087 UniProt Q16799 Q8K0T0 RefSeq (mRNA) NM_001243115 NM_021136 NM_206852 NM_206857 NM_001363702 NM_001007596 NM_001286448 NM_153457 RefSeq (protein) NP_066959 NP_996734 NP_001350631 NP_001007597 NP_001273377 NP_703187 Location (UCSC) Chr 14: 59.6 – 59.87 Mb Chr 12: 72.26 – 72.46 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Reticulon-1** also known as **neuroendocrine-specific protein** (NSP) is a [protein](/source/Protein) that in humans is encoded by the *RTN1* [gene](/source/Gene).[5][6]

This gene belongs to the family of [reticulon](/source/Reticulon)-encoding genes. Reticulons are associated with the [endoplasmic reticulum](/source/Endoplasmic_reticulum), and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. [Alternatively spliced](/source/Alternative_splicing) transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.[6]

## Interactions

RTN1 has been shown to [interact](/source/Protein-protein_interaction) with [BCL2-like 1](/source/BCL2-like_1_(gene))[7] and [UGCG](/source/UGCG).[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000139970](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000139970) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000021087](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000021087) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6252). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=104001). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8275708_5-0)** Kools PF, Roebroek AJ, Van de Velde HJ, Marynen P, Bullerdiek J, Van de Ven WJ (February 1994). "Regional mapping of the human NSP gene to chromosome region 14q21→q22 by fluorescence in situ hybridization analysis". *Cytogenet Cell Genet*. **66** (1): 48–50. [doi](/source/Doi_(identifier)):[10.1159/000133662](https://doi.org/10.1159%2F000133662). [PMID](/source/PMID_(identifier)) [8275708](https://pubmed.ncbi.nlm.nih.gov/8275708).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: RTN1 reticulon 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6252).

1. **[^](#cite_ref-pmid11126360_7-0)** Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (November 2000). ["A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"](https://doi.org/10.1038%2Fsj.onc.1203948). *Oncogene*. **19** (50): 5736–46. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1203948](https://doi.org/10.1038%2Fsj.onc.1203948). [PMID](/source/PMID_(identifier)) [11126360](https://pubmed.ncbi.nlm.nih.gov/11126360).

1. **[^](#cite_ref-pmid12873973_8-0)** Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (July 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". *Cancer Res*. **63** (14): 3860–5. [PMID](/source/PMID_(identifier)) [12873973](https://pubmed.ncbi.nlm.nih.gov/12873973).

## Further reading

- Senden NH, van de Velde HJ, Broers JL, Timmer ED, Roebroek AJ, van de Ven WJ, Ramaekers FC (1994). "Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum". *Int. J. Cancer Suppl*. **8**: 84–8. [doi](/source/Doi_(identifier)):[10.1002/ijc.2910570718](https://doi.org/10.1002%2Fijc.2910570718). [PMID](/source/PMID_(identifier)) [7515034](https://pubmed.ncbi.nlm.nih.gov/7515034). [S2CID](/source/S2CID_(identifier)) [22321780](https://api.semanticscholar.org/CorpusID:22321780).

- Roebroek AJ, van de Velde HJ, Van Bokhoven A, Broers JL, Ramaekers FC, Van de Ven WJ (1993). ["Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product"](https://doi.org/10.1016%2FS0021-9258%2819%2938669-7). *J. Biol. Chem*. **268** (18): 13439–47. [doi](/source/Doi_(identifier)):[10.1016/S0021-9258(19)38669-7](https://doi.org/10.1016%2FS0021-9258%2819%2938669-7). [PMID](/source/PMID_(identifier)) [7685762](https://pubmed.ncbi.nlm.nih.gov/7685762).

- van de Velde HJ, Roebroek AJ, Senden NH, Ramaekers FC, Van de Ven WJ (1995). "NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum". *J. Cell Sci*. **107** (9): 2403–16. [doi](/source/Doi_(identifier)):[10.1242/jcs.107.9.2403](https://doi.org/10.1242%2Fjcs.107.9.2403). [PMID](/source/PMID_(identifier)) [7844160](https://pubmed.ncbi.nlm.nih.gov/7844160).

- van de Velde HJ, Senden NH, Roskams TA, Broers JL, Ramaekers FC, Roebroek AJ, Van de Ven WJ (1994). "NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis". *Cancer Res*. **54** (17): 4769–76. [PMID](/source/PMID_(identifier)) [8062278](https://pubmed.ncbi.nlm.nih.gov/8062278).

- Roebroek AJ, Ayoubi TA, Van de Velde HJ, Schoenmakers EF, Pauli IG, Van de Ven WJ (1997). "Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons". *Genomics*. **32** (2): 191–9. [doi](/source/Doi_(identifier)):[10.1006/geno.1996.0105](https://doi.org/10.1006%2Fgeno.1996.0105). [PMID](/source/PMID_(identifier)) [8833145](https://pubmed.ncbi.nlm.nih.gov/8833145).

- Bonaldo MF, Lennon G, Soares MB (1997). ["Normalization and subtraction: two approaches to facilitate gene discovery"](https://doi.org/10.1101%2Fgr.6.9.791). *Genome Res*. **6** (9): 791–806. [doi](/source/Doi_(identifier)):[10.1101/gr.6.9.791](https://doi.org/10.1101%2Fgr.6.9.791). [PMID](/source/PMID_(identifier)) [8889548](https://pubmed.ncbi.nlm.nih.gov/8889548).

- Senden NH, Timmer ED, Boers JE, van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC (1996). "Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A". *Eur. J. Cell Biol*. **69** (3): 197–213. [PMID](/source/PMID_(identifier)) [8900485](https://pubmed.ncbi.nlm.nih.gov/8900485).

- Hens J, Nuydens R, Geerts H, Senden NH, Van de Ven WJ, Roebroek AJ, van de Velde HJ, Ramaekers FC, Broers JL (1998). "Neuronal differentiation is accompanied by NSP-C expression". *Cell Tissue Res*. **292** (2): 229–37. [doi](/source/Doi_(identifier)):[10.1007/s004410051054](https://doi.org/10.1007%2Fs004410051054). [PMID](/source/PMID_(identifier)) [9560466](https://pubmed.ncbi.nlm.nih.gov/9560466). [S2CID](/source/S2CID_(identifier)) [1743385](https://api.semanticscholar.org/CorpusID:1743385).

- Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (2001). ["A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"](https://doi.org/10.1038%2Fsj.onc.1203948). *Oncogene*. **19** (50): 5736–46. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1203948](https://doi.org/10.1038%2Fsj.onc.1203948). [PMID](/source/PMID_(identifier)) [11126360](https://pubmed.ncbi.nlm.nih.gov/11126360).

- Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). ["A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family"](https://doi.org/10.1096%2Ffj.02-1166hyp). *FASEB J*. **17** (10): 1238–47. [CiteSeerX](/source/CiteSeerX_(identifier)) [10.1.1.124.969](https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.124.969). [doi](/source/Doi_(identifier)):[10.1096/fj.02-1166hyp](https://doi.org/10.1096%2Ffj.02-1166hyp). [PMID](/source/PMID_(identifier)) [12832288](https://pubmed.ncbi.nlm.nih.gov/12832288). [S2CID](/source/S2CID_(identifier)) [27903](https://api.semanticscholar.org/CorpusID:27903).

- Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". *Cancer Res*. **63** (14): 3860–5. [PMID](/source/PMID_(identifier)) [12873973](https://pubmed.ncbi.nlm.nih.gov/12873973).

- Iwahashi J, Hamada N (2004). "Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex". *Cell. Mol. Biol. (Noisy-le-grand)*. 49 Online Pub: OL467–71. [PMID](/source/PMID_(identifier)) [14995077](https://pubmed.ncbi.nlm.nih.gov/14995077).

- Hu Y, Fang X, Dunham SM, Prada C, Stachowiak EK, Stachowiak MK (2004). ["90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling"](https://doi.org/10.1074%2Fjbc.M311144200). *J. Biol. Chem*. **279** (28): 29325–35. [doi](/source/Doi_(identifier)):[10.1074/jbc.M311144200](https://doi.org/10.1074%2Fjbc.M311144200). [PMID](/source/PMID_(identifier)) [15117958](https://pubmed.ncbi.nlm.nih.gov/15117958).

- He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". *Nat. Med*. **10** (9): 959–65. [doi](/source/Doi_(identifier)):[10.1038/nm1088](https://doi.org/10.1038%2Fnm1088). [PMID](/source/PMID_(identifier)) [15286784](https://pubmed.ncbi.nlm.nih.gov/15286784). [S2CID](/source/S2CID_(identifier)) [23570406](https://api.semanticscholar.org/CorpusID:23570406).

- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Mannan AU, Boehm J, Sauter SM, Rauber A, Byrne PC, Neesen J, Engel W (2007). "Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein". *Neurogenetics*. **7** (2): 93–103. [doi](/source/Doi_(identifier)):[10.1007/s10048-006-0034-4](https://doi.org/10.1007%2Fs10048-006-0034-4). [PMID](/source/PMID_(identifier)) [16602018](https://pubmed.ncbi.nlm.nih.gov/16602018). [S2CID](/source/S2CID_(identifier)) [8509463](https://api.semanticscholar.org/CorpusID:8509463).

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