# RTL3

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Protein-coding gene in the species Homo sapiens

RTL3 Identifiers Aliases RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3 External IDs MGI: 2685221; HomoloGene: 19397; GeneCards: RTL3; OMA:RTL3 - orthologs Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,656,068 bp[1] End 78,659,328 bp[1] Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 105,880,688 bp[2] End 105,884,250 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa right coronary artery ascending aorta tibia Achilles tendon apex of heart smooth muscle tissue popliteal artery tibial arteries left coronary artery Top expressed in efferent ductule tongue muscle dermis human fetus condyle internal carotid artery intrinsic muscle of tongue external carotid artery extrinsic muscle of tongue atrioventricular valve More reference expression data BioGPS n/a Orthologs Species Human Mouse Entrez 203430 213436 Ensembl ENSG00000179300 ENSMUSG00000047686 UniProt Q8N8U3 Q6P1Y1 RefSeq (mRNA) NM_152694 NM_199468 RefSeq (protein) NP_689907 NP_955762 Location (UCSC) Chr X: 78.66 – 78.66 Mb Chr X: 105.88 – 105.88 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Retrotransposon Gag like 3** is a [protein](/source/Protein) that in humans is encoded by the RTL3 [gene](/source/Gene). [5]

## Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their [open reading frames](/source/Open_reading_frame) have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000179300](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000179300) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000047686](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000047686) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=203430). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=213436). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-entrez_5-0)** ["Entrez Gene: Retrotransposon Gag like 3"](https://www.ncbi.nlm.nih.gov/gene/203430). Retrieved 2017-09-18.

1. ^ [***a***](#cite_ref-Ball_2021_6-0) [***b***](#cite_ref-Ball_2021_6-1) Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). ["A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404968). *Connective Tissue Research*. **62** (6): 615–628. [doi](/source/Doi_(identifier)):[10.1080/03008207.2020.1828380](https://doi.org/10.1080%2F03008207.2020.1828380). [PMC](/source/PMC_(identifier)) [8404968](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404968). [PMID](/source/PMID_(identifier)) [33043724](https://pubmed.ncbi.nlm.nih.gov/33043724).

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

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Adapted from the Wikipedia article [RTL3](https://en.wikipedia.org/wiki/RTL3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/RTL3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.