# RELT
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> Source: https://en.wikipedia.org/wiki/RELT
> Source revision: 1342980359
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Tumor necrosis factor receptor superfamily member 19L''' is a [protein](/source/protein) that in humans is encoded by the ''RELT'' [gene](/source/gene).[{{cite journal | vauthors = Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L | title = RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB | journal = Blood | volume = 97 | issue = 9 | pages = 2702–7 | date = Apr 2001 | pmid = 11313261 | doi = 10.1182/blood.V97.9.2702 | s2cid = 6347356 | doi-access = free }}][{{cite journal | vauthors = Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P | title = Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human | journal = J Biol Chem | volume = 281 | issue = 20 | pages = 13964–71 | date = May 2006 | pmid = 16547002 | doi = 10.1074/jbc.M601553200 | doi-access = free | url = https://serval.unil.ch/resource/serval:BIB_194DF0126EE5.P001/REF.pdf }}][{{cite journal | vauthors = Polek TC, Talpaz M, Spivak-Kroizman TR | title = TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis | journal = Biochem Biophys Res Commun | volume = 349 | issue = 3 | pages = 1016–24 | date = Sep 2006 | pmid = 16950202 | doi = 10.1016/j.bbrc.2006.08.118 }}][{{cite journal | vauthors = Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB | title = Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1 | journal = Biochem Biophys Res Commun | volume = 340 | issue = 2 | pages = 535–43 | date = Jan 2006 | pmid = 16389068 | doi = 10.1016/j.bbrc.2005.12.033 }}][{{cite web | title = Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=84957}}]
== Function ==
The protein encoded by this gene is a member of the [TNF-receptor](/source/TNF-receptor) superfamily. This receptor is especially abundant in [hematologic](/source/hematologic) tissues. It has been shown to activate the [NF-kappaB pathway](/source/NF-kappaB_pathway) and selectively bind TNF receptor-associated factor 1 ([TRAF1](/source/TRAF1)). This receptor is capable of stimulating [T-cell](/source/T-cell) proliferation in the presence of [CD3](/source/CD3_(immunology)) signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.