# RBL cells

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**RBL** (Rat Basophilic Leukemia cells)[1] are cancerous [basophil](/source/Basophil) cells that are well suited for the study of allergies.[2]

## Uses

RBL cells are used in allergy studies due to the strong response of the cells to [IgE](/source/IgE) and its [FcεRI](/source/Fc%CE%B5RI) receptor. They are used in place of mast cells due to a higher stability in tissue culture.[3] RBL cells can also be [humanized](/source/Humanized_mouse), aiding in the specificity of allergy studies to human patients.[4]

## Infections

[Mycoplasma](/source/Mycoplasma) bacterial infections greatly affects the cell mediator release for biological assays, therefore regular Mycoplasma tests need to be performed since the bacteria colonizes the cell surface and cannot be visualized through a light microscope.[citation needed]

## References

1. Bingham, B.R.; Monk, P.N.; Helm, B.A. (1994). "Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line". *The Journal of Biological Chemistry*. **269** (30): 19300–19306. [doi:10.1016/S0021-9258(17)32167-1](https://doi.org/10.1016/S0021-9258(17)32167-1)

1. Yoo, Jae-Myung et al. (1 January 2014). "Anti-Allergic Action of Aged Black Garlic Extract in RBL-2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice". *J Med Food*. **17** (1): 92–102. [doi:10.1089/jmf.2013.2927](https://doi.org/10.1089/jmf.2013.2927). [PMC 3901385](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901385). [PMID 24456359](https://pubmed.ncbi.nlm.nih.gov/24456359)

1. Wang, Weimin et al. (2012). ["Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells"](https://if-pan.krakow.pl/pjp/pdf/2012/5_1216.pdf). *Pharmacological Reports*. **64** (5): 1216–1222. [doi:10.1016/S1734-1140(12)70917-9](https://doi.org/10.1016/S1734-1140(12)70917-9). [ISSN 1734-1140](https://www.worldcat.org/issn/1734-1140). [PMID 23238477](https://pubmed.ncbi.nlm.nih.gov/23238477). [S2CID 4715976](https://api.semanticscholar.org/CorpusID:4715976)

1. Falcone, F.H et al. (2015). "Use of Humanized Rat Basophilic Leukemia Reporter Cell Lines as a Diagnostic Tool for Detection of Allergen-Specific IgE in Allergic Patients: Time for a Reappraisal?". *Curr Allergy Asthma Rep*. **15** (67): 67. [doi:10.1007/s11882-015-0568-3](https://doi.org/10.1007/s11882-015-0568-3). [PMID 26452547](https://pubmed.ncbi.nlm.nih.gov/26452547). [S2CID 11524705](https://api.semanticscholar.org/CorpusID:11524705)

## External links

- [Cellosaurus entry for RBL](https://www.cellosaurus.org/CVCL_0496)

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Adapted from the Wikipedia article [RBL cells](https://en.wikipedia.org/wiki/RBL_cells) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/RBL_cells?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.