# RAPGEF6

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> Source: https://en.wikipedia.org/wiki/RAPGEF6
> Source revision: 1301025384
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Rap guanine nucleotide exchange factor 6''' is a [protein](/source/protein) that in humans is encoded by the ''RAPGEF6'' [gene](/source/gene).<ref name="pmid11524421">{{cite journal |vauthors=Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T | title = Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras | journal = J Biol Chem | volume = 276 | issue = 45 | pages = 42219–42225 |date=Nov 2001 | pmid = 11524421 | doi = 10.1074/jbc.M105760200 | doi-access = free }}</ref><ref name="pmid12095257">{{cite journal |vauthors=Kozlov G, Banville D, Gehring K, Ekiel I | title = Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions | journal = J Mol Biol | volume = 320 | issue = 4 | pages = 813–820 |date=Jul 2002 | pmid = 12095257 | doi =10.1016/S0022-2836(02)00544-2  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51735}}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–648 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-style=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias |s2cid=7827573 | doi-access=free}}
*{{cite journal  | author=Chen X |title=Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia |journal=Hum. Mol. Genet. |volume=15 |issue= 22 |pages= 3329–3342 |year= 2006 |pmid= 17030554 |doi= 10.1093/hmg/ddl409  |name-list-style=vanc| author2=Wang X  | author3=Hossain S  | display-authors=3  | last4=O'Neill  | first4=F. A.  | last5=Walsh  | first5=D.  | last6=Pless  | first6=L.  | last7=Chowdari  | first7=K. V.  | last8=Nimgaonkar  | first8=V. L.  | last9=Schwab  | first9=S. G. | doi-access=free  }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–12135 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-style=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP |bibcode=2004PNAS..10112130B |doi-access=free }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-style=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
*{{cite journal  | author=Kuiperij HB |title=Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2 |journal=Biochim. Biophys. Acta |volume=1593 |issue= 2–3 |pages= 141–149 |year= 2003 |pmid= 12581858 |doi=10.1016/S0167-4889(02)00365-8  |name-list-style=vanc| author2=de Rooij J  | author3=Rehmann H  | display-authors=3  | last4=Van Triest  | first4=M  | last5=Wittinghofer  | first5=A  | last6=Bos  | first6=JL  | last7=Zwartkruis  | first7=FJ  | doi-access=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=51735}}

{{protein-stub}}

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Adapted from the Wikipedia article [RAPGEF6](https://en.wikipedia.org/wiki/RAPGEF6) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/RAPGEF6?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.