# Pinc

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Pregnancy-induced noncoding RNA

Pregnancy induced noncoding RNA Identifiers Organism mouse Symbol Pinc Entrez 723792 RefSeq (mRNA) NR_003202 Other data Chromosome 1: 73.44 - 73.45 Mb

**Pinc** (pregnancy induced noncoding RNA) is a [long non-coding RNA](/source/Long_non-coding_RNA). It was originally identified in the [mammary glands](/source/Mammary_glands) of [oestrogen](/source/Oestrogen) and [progesterone](/source/Progesterone)-treated rats.[1] Pinc may be a [mammal](/source/Mammal)-specific gene. It is conserved in a number of mammalian [genomes](/source/Genomes) ([human](/source/Human), [mouse](/source/Mouse), [rat](/source/Rat), [chimpanzee](/source/Common_chimpanzee), [dog](/source/Dog), [cow](/source/Cow) and [opossum](/source/Opossum)), but not in [fugu](/source/Fugu), [zebrafish](/source/Zebrafish) or [xenopus](/source/Xenopus) genomes.[2]

In mice, Pinc is expressed in the developing [embryo](/source/Embryo) and in the mammary glands of adults. Its expression in the mammary gland is [induced](/source/Regulation_of_gene_expression) by pregnancy and drops during [lactation](/source/Lactation). It may have a role in [cell](/source/Cell_(biology)) survival and in the regulation of [cell cycle](/source/Cell_cycle) progression.[2]

## See also

- [Long noncoding RNA](/source/Long_noncoding_RNA)

## References

1. **[^](#cite_ref-pmid11682629_1-0)** Ginger MR, Gonzalez-Rimbau MF, Gay JP, [Rosen JM](/source/Jeffrey_M._Rosen) (November 2001). ["Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland"](https://doi.org/10.1210%2Fmend.15.11.0724). *Mol. Endocrinol*. **15** (11): 1993–2009. [doi](/source/Doi_(identifier)):[10.1210/mend.15.11.0724](https://doi.org/10.1210%2Fmend.15.11.0724). [PMID](/source/PMID_(identifier)) [11682629](https://pubmed.ncbi.nlm.nih.gov/11682629).

1. ^ [***a***](#cite_ref-pmid16574773_2-0) [***b***](#cite_ref-pmid16574773_2-1) Ginger MR, Shore AN, Contreras A, et al. (April 2006). ["A noncoding RNA is a potential marker of cell fate during mammary gland development"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420634). *Proc. Natl. Acad. Sci. U.S.A*. **103** (15): 5781–5786. [Bibcode](/source/Bibcode_(identifier)):[2006PNAS..103.5781G](https://ui.adsabs.harvard.edu/abs/2006PNAS..103.5781G). [doi](/source/Doi_(identifier)):[10.1073/pnas.0600745103](https://doi.org/10.1073%2Fpnas.0600745103). [PMC](/source/PMC_(identifier)) [1420634](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420634). [PMID](/source/PMID_(identifier)) [16574773](https://pubmed.ncbi.nlm.nih.gov/16574773).

## Further reading

- Mattick JS (April 2009). Lee, Jeannie T. (ed.). ["The genetic signatures of noncoding RNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667263). *PLOS Genet*. **5** (4) e1000459. [doi](/source/Doi_(identifier)):[10.1371/journal.pgen.1000459](https://doi.org/10.1371%2Fjournal.pgen.1000459). [PMC](/source/PMC_(identifier)) [2667263](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667263). [PMID](/source/PMID_(identifier)) [19390609](https://pubmed.ncbi.nlm.nih.gov/19390609).

## External links

- [MGI entry for Pinc](http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=171780)

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