# Phosducin > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Phosducin > Markdown URL: https://mediated.wiki/source/Phosducin.md > Source: https://en.wikipedia.org/wiki/Phosducin > Source revision: 1301330668 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Phosducin''', also known as '''PDC''', is a human [protein](/source/protein) and [gene](/source/gene).{{cite web | title = Entrez Gene: PDC phosducin| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5132}} It belongs to the [phosducin family](/source/phosducin_family) of proteins. This gene encodes a [phosphoprotein](/source/phosphoprotein), which is located in the outer and inner segments of the rod cells in the [retina](/source/retina). This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation. This gene is a potential candidate gene for [retinitis pigmentosa](/source/retinitis_pigmentosa) and [Usher syndrome type II](/source/Usher_syndrome). Alternatively spliced transcript variants encoding different isoforms have been identified. ==See also== *[Phosducin family](/source/Phosducin_family) ==References== {{reflist}} ==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Abe T, Nakabayashi H, Tamada H, etal |title=Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland |journal=Gene |volume=91 |issue= 2 |pages= 209–15 |year= 1990 |pmid= 2210381 |doi=10.1016/0378-1119(90)90090-E |url=https://zenodo.org/record/1258513 }} *{{cite journal |vauthors=Watanabe Y, Kawasaki K, Miki N, Kuo CH |title=Isolation and analysis of the human MEKA gene encoding a retina-specific protein |journal=Biochem. Biophys. Res. Commun. |volume=170 |issue= 2 |pages= 951–6 |year= 1990 |pmid= 2383274 |doi=10.1016/0006-291X(90)92183-Z }} *{{cite journal |vauthors=Lee RH, Brown BM, Lolley RN |title=Protein kinase A phosphorylates retinal phosducin on serine 73 in situ |journal=J. Biol. Chem. |volume=265 |issue= 26 |pages= 15860–6 |year= 1990 |doi=10.1016/S0021-9258(18)55478-8 |pmid= 2394752 |doi-access=free }} *{{cite journal |vauthors=Hawes BE, Touhara K, Kurose H, etal |title=Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling |journal=J. Biol. Chem. |volume=269 |issue= 47 |pages= 29825–30 |year= 1994 |doi=10.1016/S0021-9258(18)43955-5 |pmid= 7961975 |doi-access=free }} *{{cite journal |vauthors=Abe T, Kikuchi T, Shinohara T |title=The sequence of the human phosducin gene (PDC) and its 5'-flanking region |journal=Genomics |volume=19 |issue= 2 |pages= 369–72 |year= 1994 |pmid= 8188267 |doi= 10.1006/geno.1994.1072 |url=https://zenodo.org/record/1229626 }} *{{cite journal |vauthors=Sparkes RS, Lee RH, Shinohara T, etal |title=Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization |journal=Genomics |volume=18 |issue= 2 |pages= 426–8 |year= 1994 |pmid= 8288249 |doi= 10.1006/geno.1993.1490 }} *{{cite journal |vauthors=Ding C, Li X, Griffin CA, etal |title=The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1 |journal=Genomics |volume=18 |issue= 2 |pages= 457–9 |year= 1994 |pmid= 8288259 |doi= 10.1006/geno.1993.1501 |doi-access= free }} *{{cite journal |vauthors=Boekhoff I, Touhara K, Danner S, etal |title=Phosducin, potential role in modulation of olfactory signaling |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4606–12 |year= 1997 |pmid= 9020189 |doi=10.1074/jbc.272.7.4606 |doi-access=free }} *{{cite journal |vauthors=Barhite S, Thibault C, Miles MF |title=Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1 |journal=Biochim. Biophys. Acta |volume=1402 |issue= 1 |pages= 95–101 |year= 1998 |pmid= 9551090 |doi=10.1016/S0167-4889(97)00141-9 |doi-access=free }} *{{cite journal |vauthors=Zhu X, Craft CM |title=Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1 |journal=Mol. Vis. |volume=4 |pages= 13 |year= 1998 |pmid= 9701609 }} *{{cite journal |vauthors=Craft CM, Xu J, Slepak VZ, etal |title=PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins |journal=Biochemistry |volume=37 |issue= 45 |pages= 15758–72 |year= 1998 |pmid= 9843381 |doi= 10.1021/bi980921a }} *{{cite journal |vauthors=Carpten JD, Makalowska I, Robbins CM, etal |title=A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region |journal=Genomics |volume=64 |issue= 1 |pages= 1–14 |year= 2000 |pmid= 10708513 |doi= 10.1006/geno.1999.6051 |url=https://zenodo.org/record/1229796 }} *{{cite journal |vauthors=Zhu X, Craft CM |title=The carboxyl terminal domain of phosducin functions as a transcriptional activator |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 2 |pages= 504–9 |year= 2000 |pmid= 10753654 |doi= 10.1006/bbrc.2000.2414 |url=https://zenodo.org/record/1063672 }} *{{cite journal |vauthors=Zhu X, Craft CM |title=Modulation of CRX transactivation activity by phosducin isoforms |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5216–26 |year= 2000 |pmid= 10866677 |doi=10.1128/MCB.20.14.5216-5226.2000 | pmc=85970 }} *{{cite journal |vauthors=Ruiz-Gómez A, Humrich J, Murga C, etal |title=Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2 |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29724–30 |year= 2000 |pmid= 10884381 |doi= 10.1074/jbc.M001864200 |doi-access= free }} *{{cite journal |vauthors=Nakano K, Chen J, Tarr GE, etal |title=Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4693–8 |year= 2001 |pmid= 11287646 |doi= 10.1073/pnas.071067198 | pmc=31896 |bibcode=2001PNAS...98.4693N |doi-access=free }} *{{cite journal |vauthors=Thulin CD, Savage JR, McLaughlin JN, etal |title=Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23805–15 |year= 2001 |pmid= 11331285 |doi= 10.1074/jbc.M101482200 |doi-access= free }} *{{cite journal |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts |journal=Mol. Vis. |volume=8 |pages= 196–204 |year= 2002 |pmid= 12107411 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Margulis A, Dang L, Pulukuri S, etal |title=Presence of phosducin in the nuclei of bovine retinal cells |journal=Mol. Vis. |volume=8 |pages= 477–82 |year= 2002 |pmid= 12500174 }} {{refend}} {{PDB Gallery|geneid=5132}} {{gene-1-stub}} --- Adapted from the Wikipedia article [Phosducin](https://en.wikipedia.org/wiki/Phosducin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Phosducin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.