# Pertine

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[[File:Oxypertine.svg|thumb|right|200px|class=skin-invert-image|[Oxypertine](/source/Oxypertine), the most well-known drug of the pertine group.]]

The '''pertines''', also known as '''phenylpiperazinylethylindoles''', are a group of [antipsychotic](/source/antipsychotic)s of the [cyclized tryptamine](/source/cyclized_tryptamine) and [phenylpiperazine](/source/substituted_phenylpiperazine) families that includes the following [drug](/source/drug)s:<ref name="Elks2014">{{cite book | last=Elks | first=J. | title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | publisher=Springer | date=14 November 2014 | isbn=978-1-4757-2085-3 | url=https://books.google.com/books?id=0vXTBwAAQBAJ | access-date=18 June 2025 | page=}}</ref><ref name="MegensKennis1996">{{cite journal | vauthors = Megens AA, Kennis LE | title = Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent? | journal = Prog Med Chem | series = Progress in Medicinal Chemistry | volume = 33 | issue = | pages = 185–232 | date = 1996 | pmid = 8776944 | doi = 10.1016/s0079-6468(08)70306-0 | isbn = 978-0-444-82310-6 | url = }}</ref>

* [Alpertine](/source/Alpertine) (WIN-31665)
* [Milipertine](/source/Milipertine) (WIN-18935)
* [Oxypertine](/source/Oxypertine) (WIN-18501)
* [Solypertine](/source/Solypertine) (WIN-18413)

Oxypertine is known to show high [affinity](/source/affinity_(pharmacology)) for the [serotonin](/source/serotonin) [5-HT<sub>2</sub>](/source/5-HT2_receptor) and [dopamine](/source/dopamine) [D<sub>2</sub> receptor](/source/D2_receptor)s (K<sub>i</sub> = 8.6{{nbsp}}nM and 30{{nbsp}}nM, respectively) and to also act as a [catecholamine depleting agent](/source/monoamine_depleting_agent).<ref name="MegensKennis1996" /><ref name="BakHasslerKim1969">{{cite journal | vauthors = Bak IJ, Hassler R, Kim JS | title = Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin | journal = Zeitschrift für Zellforschung und Mikroskopische Anatomie | volume = 101 | issue = 3 | pages = 448–462 | year = 1969 | pmid = 5362847 | doi = 10.1007/BF00335580 | s2cid = 32583722 }}</ref> Oxypertine, milipertine, and solypertine  all antagonize the behavioral effects of [tryptamine](/source/tryptamine), a [serotonin receptor](/source/serotonin_receptor) [agonist](/source/agonist), and [apomorphine](/source/apomorphine), a [dopamine receptor](/source/dopamine_receptor) [agonist](/source/agonist), in animals.<ref name="MegensKennis1996" /><ref name="NiemegeersJanssen1979">{{cite journal | vauthors = Niemegeers CJ, Janssen PA | title = A systematic study of the pharmacological activities of dopamine antagonists | journal = Life Sciences | volume = 24 | issue = 24 | pages = 2201–2216 | date = June 1979 | pmid = 388130 | doi = 10.1016/0024-3205(79)90096-1 | publisher = Elsevier BV }}</ref>

Some of the pertines, like milipertine and solypertine, are notable in containing an [NBOMe](/source/NBOMe)-like [moiety](/source/moiety_(chemistry)).<ref name="Elks2014" /><ref name="MegensKennis1996" />

The pertines were developed and initially described in the 1960s and 1970s.<ref name="Elks2014" />

{{Gallery
| title = Chemical structures of pertines
| height = 145
| width = 145
| File:Alpertine.svg | class1=skin-invert-image | [Alpertine](/source/Alpertine)
| File:Milipertine.svg | class2=skin-invert-image | [Milipertine](/source/Milipertine)
| File:Oxypertine.svg | class3=skin-invert-image | [Oxypertine](/source/Oxypertine)
| File:Solypertine.svg | class4=skin-invert-image | [Solypertine](/source/Solypertine)
}}

==See also==
* [Cyclized tryptamine](/source/Cyclized_tryptamine)
* [5-MeO-T-NBOMe](/source/5-MeO-T-NBOMe)
* [''N''-Benzyltryptamine](/source/N-Benzyltryptamine)
* [Carmoxirole](/source/Carmoxirole)
* [B-193](/source/B-193)

==References==
{{Reflist}}

{{Antipsychotics}}
{{Tryptamines}}
{{Arylpiperazines}}

Category:Pertines

{{Nervous-system-drug-stub}}

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Adapted from the Wikipedia article [Pertine](https://en.wikipedia.org/wiki/Pertine) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Pertine?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.